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[ CAS No. 40019-27-0 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 40019-27-0
Chemical Structure| 40019-27-0
Structure of 40019-27-0 *Storage: {[proInfo.prStorage]}

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Alternatived Products of [ 40019-27-0 ]

Product Details of [ 40019-27-0 ]

CAS No. :40019-27-0MDL No. :
Formula : C8H10N2O5 Boiling Point : -
Linear Structure Formula :-InChI Key :-
M.W :214.18Pubchem ID :-
Synonyms :

Computed Properties of [ 40019-27-0 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 40019-27-0 ]

Signal Word:Class:
Precautionary Statements:UN#:
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Application In Synthesis of [ 40019-27-0 ]

  • Downstream synthetic route of [ 40019-27-0 ]

[ 40019-27-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 10489-74-4 ]
  • [ 4755-77-5 ]
  • [ 40019-27-0 ]
YieldReaction ConditionsOperation in experiment
> 99% With pyridine; In chloroform; at 0 - 20℃; for 4.5h;Reflux; A 1-l,three-neck flask equipped with a magnetic stir bar, refluxcondenser, drying tube, dropping funnel, and thermometerwas charged with ethyl 2-amino-2-(hydroxyimino)acetate(32)74 (32.0 g, 242 mmol) and CHCl3 (500 ml). Anhydrouspyridine (59.0 ml, 732 mmol) was added to the slurry, andthe reaction mixture was cooled with an ice bath (internaltemperature 5-10C). Ethyl chlorooxoacetate (40.6 ml,363 mmol) was added over a period of 1 h from thedropping funnel at such a rate to maintain the reactiontemperature around 10C. The cooling bath was removed,the reaction mixture was stirred at room temperature for30 min and then refluxed for 3 h. A fine precipitateimpurity was formed during reflux, which was filtered offafter cooling to room temperature. The CHCl3 solution wasdiluted with CH2Cl2 and washed successively with 1 N HCl(3×300 ml), H2O (2×300 ml), and brine (2×300 ml). Theorganic layer was dried with anhydrous Na2SO4, and theorganic solution concentrated to give product 33 that wasused in the next step without any further purification. Yield52 g (>99%), colorless oil. IR spectrum (ATR, neat), nu, cm-1:1752 (C=O). 1H NMR spectrum (600 MHz, CDCl3),delta, ppm: 4.67-4.41 (4H, m, 2CH2); 1.54-1.37 (6H, m,2CH3). 13C NMR spectrum (150 MHz, CDCl3), delta, ppm:167.7; 162.6; 156.5; 153.2; 64.3; 63.4; 14.0; 13.9.
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