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CAS No. : | 41252-79-3 | MDL No. : | MFCD07784073 |
Formula : | C8H8Cl2O | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 191.06 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Class: | ||
Precautionary Statements: | UN#: | ||
Hazard Statements: | Packing Group: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
80% | With Vilsmeier reagent; In dichloromethane; at 40.0℃; for 12.0h;Inert atmosphere; Schlenk technique; | General procedure: A 25 mL oven-dried reaction Schlenk tube was added with the vicinal diol 1 (1.0 mmol, 1.0 equiv) and DCM (4.0 mL). Vilsmeier reagent (153.6 mg, 1.2 mmol, 1.2 equiv) was added to the solution under nitrogen. The resulting solution was stirred at 40 C for 12 h.After cooling to room temperature, the reaction mixture was added to aqueous NaHCO3 (5%, 10 mL), aqueous phase was extracted with DCM (5 mL 3). The combined organic phase was washed with brine, and then dried over anhydrous Na2SO4. After the solvent was removed under vacuum, the residue was purified by column chromatography to give the corresponding products. |