[ CAS No. 49562-28-9 ] {[proInfo.proName]}

Name: 49562-28-9|Isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate|97%
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Quality Control of [ 49562-28-9 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

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Product Details of [ 49562-28-9 ]

CAS No. :	49562-28-9	MDL No. :
Formula :	C₂₀H₂₁ClO₄	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	YMTINGFKWWXKFG-UHFFFAOYSA-N
M.W :	360.83	Pubchem ID :	3339
Synonyms :	NSC-281319

Calculated chemistry of [ 49562-28-9 ]

Physicochemical Properties

Num. heavy atoms :	25
Num. arom. heavy atoms :	12
Fraction Csp3 :	0.3
Num. rotatable bonds :	7
Num. H-bond acceptors :	4.0
Num. H-bond donors :	0.0
Molar Refractivity :	97.98
TPSA :	52.6 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	Yes
CYP2C9 inhibitor :	Yes
CYP2D6 inhibitor :	Yes
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-4.83 cm/s

Lipophilicity

Log Po/w (iLOGP) :	3.64
Log Po/w (XLOGP3) :	5.17
Log Po/w (WLOGP) :	4.68
Log Po/w (MLOGP) :	3.54
Log Po/w (SILICOS-IT) :	4.95
Consensus Log Po/w :	4.4

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-5.23
Solubility :	0.00214 mg/ml ; 0.00000592 mol/l
Class :	Moderately soluble
Log S (Ali) :	-6.02
Solubility :	0.000344 mg/ml ; 0.000000953 mol/l
Class :	Poorly soluble
Log S (SILICOS-IT) :	-6.51
Solubility :	0.000112 mg/ml ; 0.00000031 mol/l
Class :	Poorly soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	2.0
Synthetic accessibility :	2.64

Safety of [ 49562-28-9 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 49562-28-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 49562-28-9 ]
Downstream synthetic route of [ 49562-28-9 ]

[ 49562-28-9 ] Synthesis Path-Upstream 1~1

1
[ 49562-28-9 ]
[ 42017-89-0 ]

Yield	Reaction Conditions	Operation in experiment
15%	Stage #1: With lithium hydroxide monohydrate; water In tetrahydrofuranReflux Stage #2: With hydrogenchloride In tetrahydrofuran; water	Example 12 - Formula 139 - Compounds 12a _{12bIntermediate B: 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoic acid To a stirred solution of compound A (1 .0 g, 2.77 mmol) in THF (10 mL) was added LiOH-H&2}0 (0.7 g, 16.6 mmol) and H₂0 (10 mL). The resulting mixture was heated at reflux overnight then quenched with a 1 M aqueous HCI solution and extracted with EtOAc (10 mL x 3). The combined organic layers were washed with brine, dried over MgS0₄ and concentrated under reduced pressure. The residue was purified by flash chromatography (CH₂Cl2/MeOH, 15/1 , v/v) to give 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoic acid (130 mg, 15percent) as a white solid.LC-MS (Agilent): R_t 3.00 min; m/z calculated for Ci₇H₁₅CI0₄ [M+H]⁺ 319.07, found 319.1 .
15%	With lithium hydroxide monohydrate; water In tetrahydrofuranReflux	To a stirred solution of compound A (1.0 g, 2.77 mmol) in THF (10 mL) was added LiOH.H₂O (0.7 g, 16.6 mmol) and H₂O (10 mL). The resulting mixture was heated at reflux overnight then quenched with a 1 M aqueous HCl solution and extracted with EtOAc (10 mL*3). The combined organic layers were washed with brine, dried over MgSO₄ and concentrated under reduced pressure. The residue was purified by flash chromatography (CH₂Cl₂/MeOH, 15/1, v/v) to give 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoic acid (130 mg, 15percent) as a white solid. LC-MS (Agilent): R_t 3.00 min; m/z calculated for C₁₇H₁₅ClO₄ [M+H]⁺ 319.07. found 319.1.

Reference： [1] Tetrahedron Letters, 2007, vol. 48, # 14, p. 2497 - 2499
[2] Acta Crystallographica Section C: Crystal Structure Communications, 2005, vol. 61, # 2, p. o81-o84
[3] Patent: WO2012/63085, 2012, A2, . Location in patent: Page/Page column 83-84
[4] Patent: US2013/225594, 2013, A1, . Location in patent: Paragraph 0268; 0269
[5] Photochemistry and Photobiology, 2002, vol. 75, # 3, p. 193 - 200
[6] Biochemical Pharmacology, 2004, vol. 67, # 2, p. 285 - 292
[7] Farmaco, 2005, vol. 60, # 5, p. 425 - 438
[8] Crystal Growth and Design, 2014, vol. 14, # 8, p. 3800 - 3812
[9] Drug Metabolism and Disposition, 2015, vol. 43, # 11, p. 1815 - 1822

[ 49562-28-9 ] Synthesis Path-Downstream 1~88

1
[ 49562-28-9 ]
[ 61001-99-8 ]

Yield	Reaction Conditions	Operation in experiment
97%	With C28H35ClCoN5(1+)*Cl(1-); potassium tert-butylate; hydrogen; In tetrahydrofuran; at 20℃; under 37503.8 Torr; for 16h;Autoclave;	General procedure: In an argon filled glove box, the cobalt catalyst (LNHC/CoCl2 or Co-2a) and the base wereweighted into a 4mL vial equipped with a magnetic stir bar, followed by addition of the solvent.After shaking of the vial for 30 seconds, the carbonyl substrate was then added. The vial wasplaced into a Parr Instruments autoclave, which was then sealed, removed from the glove boxand purged with hydrogen gas. The autoclave was heated to certain temperature. After reactionfor 16 hours, the autoclave was cooled down to 0 oC before releasing the hydrogen gas. Forquantitative GC analysis, biphenyl (1.0 mmol) as internal standard was added. The organiclayer was then filtrated and diluted for GC analysis. The stereo-selectivity of the hydrogenatedproducts of cyclohexanones were determined by NMR with mesitylene as the internal standard.The desired hydrogenation product was further isolated by flash column chromatography.

Reference： [1]Chem,2019,vol. 5,p. 1552 - 1566
[2]Patent: FR2300552,1976,
Patent: DE2605382,1976,
Chem.Abstr.,1976,vol. 85

2
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[ 67-63-0 ]
[ 49562-28-9 ]

Yield	Reaction Conditions	Operation in experiment
97%	With magneticnanosolidsuperacid; In cyclohexane; water; at 83 - 85℃;	In the ring with a water separator, reflux condenser, thermometer, 250 mL reaction flask fenofibrate (I) (20.0 g, 0.063 mol),isopropanol (28.0 g, 0.467 mol),with aqua cyclonexane 10 mL of hexane and magnetic nano solid superacid SO 4 / Fe 3 O 4 -Al 2 O3 -ZrO 2 -Nd 2 O 3 0.36 g, warmed to 83-85 C reflux, TLC monitoring of the reaction . After completion of the reaction, thecatalyst was separated magnetically, recovery of the catalyst. The reaction solution was cooled to 0-10 C, stirred crystallization, filtration, the filter cake rinsed with isopropanol and dried to give a white solid 22.1 g, yield 97.0%. Products byNMR, MS, IR and their structures were confirmed for our target product.
96.6%		EXAMPLE; In a dual-jacket reactor of 250 mL (reactor A), 60 g of <strong>[42017-89-0]fenofibric acid</strong> (1 eq.; 0.188 moles) are introduced and 120 mL of isopropanol (2 volumes). The reaction mixture is heated with reflux. The reaction mixture is heterogeneous. To this suspension, are added 29.11 g of thionyl chloride (1.3 eq.; 0.245 moles) over 3 hours. The reaction mixture is homogenized while adding thionyl chloride in order to obtain a yellow solution. At the end of the addition, the reaction medium is maintained under reflux for about 4 hours (the reaction kinetics are followed by HPLC).In a reactor B, 28.58 g of K2CO3 (1.1 eq.; 0.21 mole) are introduced and 120 mL of water (2 volumes). The mixture is heated to 60-65 C.The contents of reactor A are hot-poured into the reactor B within about 1 hour. The reactor A is rinsed with 15 mL of isopropanol which are transferred to reactor B. The mixture is stirred for a minimum of 5 minutes. Stirring is stopped and the mixture is left to decant. The lower aqueous phase is removed. 134 mL of water are added to the alcoholic phase, while maintaining the temperature of the reaction mass at 60-65 C. The reaction mass is cooled to 50 C. and initiated with a few mg of fenofibrate. The mixture is maintained for about 30 minutes at 50 C. The medium crystallizes. The temperature is lowered to 0-5 C. within 2 hours and then maintained for a minimum of 30 minutes at this temperature (0-5 C.). The mixture is filtered. The cake is washed three times with 70 mL of water. It is dried for one night at 60 C. in a ventilated oven. 65.61 g of dry product are thereby obtained (yield=96.6%).Analytical results:HPLC (area %)Fenofibrate=99.98%<strong>[42017-89-0]Fenofibric acid</strong>=0.02%.
92.4%	With macroporous strong acid cation exchange resin D001; In water; toluene; at 110℃;	The <strong>[42017-89-0]Fenofibric acid</strong> is obtained by condensation, acidification and purification of 4-hydroxy-4-chlorobenzophenone with acetone and chloroform under the conditions of sodium hydroxide as a catalyst. <strong>[42017-89-0]Fenofibric acid</strong> (63.75 g, 0.2 mol) was added to a 500 ml flask. Isopropyl alcohol 69ml and water with toluene 100ml, After stirring and heating, after the reaction liquid reaches the specified temperature, the initial acid value of the reaction liquid is sampled and measured. At the same time, 10 g of the catalyst was added to the four-necked flask, and the timing was started, and the acid value was measured at regular intervals. In a boiling state, the water formed by the reaction is azeotropically distilled off with toluene.The aqueous phase was separated in a water separator and toluene was refluxed.As the reaction progresses, the temperature of the reaction solution gradually increases, and the temperature of the reaction solution is controlled to be within 110 C. After the reaction for a certain period of time, the reaction is stopped. The reaction solution was cooled, filtered, and neutralized with a mass concentration of 3% to 4% sodium hydroxide solution to pH = 7 to 8, and allowed to stand for stratification. The upper layer is dried with an appropriate amount of anhydrous sodium sulfate until clarification, and the clear liquid is taken. The toluene with water is distilled off under normal pressure and then under reduced pressure, and the distilled toluene is recycled. The material was cooled to 50 C, dissolved in isopropanol, cooled, filtered, and dried to obtain a yellowish crystalline powder, which was purified with isopropyl alcohol.A white solid of 66.69 g was obtained, and the esterification yield was 92.4% (based on fenofibrate acid), and the content was 99.9%.

87.70%

With sulfuric acid; In toluene; at 110℃;Green chemistry;

A four-necked flask, each of which has an electric stirring bar, a thermometer, a third port with a reflux condenser and a water separator, and a fourth port for feeding; To the four-necked flask was added 60 g of toluene, 18 g of isopropyl alcohol and 6 g of concentrated sulfuric acid. Then, 60 g of <strong>[42017-89-0]fenofibric acid</strong> was added with stirring, and the mixture was stirred at 400r to 500r / min using an electric stir bar, 110 C heated to reflux, so that the reaction of water from the water separator, toluene, a small amount of water and isopropyl alcohol through the reflux condenser flow back to the four-necked flask, when the reaction to the water and then enter the water separator to stop heating Stirring, the esterification reaction after leaving the liquid with 60 ~ 70 hot water washing, so that impurities and liquid layer, to retain the upper layer of material and toluene mixture, remove the lower water and impurities, and then to the liquid And the unreacted fenofibrate acid was neutralized by stirring, the alkali aqueous layer and the feed liquid were separated, and the alkali layer was neutralized with hydrochloric acid to pH = 3 to 4, Norbert acid, dried as raw material recovery; separation of alkaline water after the liquid with 60 ~ 70 hot water washing, so that impurities and liquid layer, the upper material and toluene mixed organic phase, the lower layer of NaOH The organic phase was separated and the organic phase was separated. The separated organic phase was placed in a three-necked flask equipped with a stir bar, a thermometer and a ball-type condensing tube, respectively, and subjected to atmospheric distillation to remove water and partially toluene , When the temperature rose to 115 after the relative vacuum to maintain the -0.08 ~ -0.1MPa, under vacuum distillation in addition to toluene; cooling to 60 , adding 150g isopropyl alcohol, 1g of medicinal activated carbon, heated to reflux 30min after the heat Filtration, cooling to 15 C, to obtain white-like fenofibrate, the product yield of 87.70%, prepared fenofibrate melting point of 79.4 ~ 80.3 .

Reference： [1]Patent: CN104311422,2016,B .Location in patent: Paragraph 0031; 0032
[2]Patent: US2010/185008,2010,A1 .Location in patent: Page/Page column 2
[3]Patent: CN109651144,2019,A .Location in patent: Paragraph 0023; 0026-0028; 0031-0033; 0036-0037
[4]Patent: CN104276950,2016,B .Location in patent: Paragraph 0018
[5]Organic and Biomolecular Chemistry,2018,vol. 16,p. 9472 - 9476
[6]Patent: FR2300552,1976,
Patent: DE2605382,1976,
Chem.Abstr.,1976,vol. 85

3
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[ 42019-78-3 ]
[ 67-63-0 ]
[ 67-64-1 ]
[ 49562-28-9 ]

Reference： [1]Arzneimittel-Forschung/Drug Research,1979,vol. 29,p. 711 - 720

Yield	Reaction Conditions	Operation in experiment
		A list including these and other examples of PPARalpha activators is as follows: ... 2-(2-chlorophenoxy)-2-methylpropanoic acid ethyl ester 2-(3-chlorophenoxy)-2-methylpropanoic acid ethyl ester 2-(4-chlorophenoxy)-2-methylpropanoic acid ethyl ester 2-(4-(4-chlorophenyl)phenoxy)-2-methylpropanoic acid ethyl ester 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoic acid isopropyl ester 2-(4-(2,2-dichlorocyclopropyl)phenoxy)-2-methylpropanoic acid 2-(4-(4-chlorobenzoylaminoethyl)phenoxy)-2-methylpropanoic acid 2-(2,3-dimethyl-4-(1,2,3,4-tetrahydronaphth-1-yl)phenoxy)acetic acid ...
		...;C10) fatty acids, long-chain monounsaturated fatty acids, and dicarboxylic acids, particularly dodecanedioic acid. Also included are lower alkyl, preferably methyl, esters of the fibrates and lower alkyl, preferably methyl, esters of the fatty acids. Fibrates include: clofibrate: 2-(4-chlorophenoxy)-2-methylpropanoic acid ethyl ester fenofibrate: 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoic acid isopropyl ester ciprofibrate: 2-(4-(2,2-dichlorocyclopropyl)phenoxy)isobutyric acid gemfibrozil: 2-(2,4-dimethylphenoxypropyl)-2-methylpropanoic acid bezafibrate: 2-(4-(4-chlorobenzoylaminoethyl)phenoxy)-2-methylpropanoic acid
		and/or hypocholesterolemiants, and more precisely the derivatives of clofibric acid such as for example clofibrate clofibride fenofibrate gemfibrozil benzafibrate

		(5) Production of isopropyl 2-methyl-2-[4-(p-chlorobenzoyl)phenoxy]-propionate (compare formula XXIV) 100 cm3 of benzene, 5 cm3 of isopropyl alcohol, 0.9 g of p-toluenesulphonic acid and 8.5 g of the preceding acid are introduced into a 250 cm3 flask surmounted by a Dean and Stark device and a condenser. The mixture is heated under reflux for 12 hours. After cooling, ether is added and the mixture is washed with aqueous sodium hydroxide solution (strength 30 g/l) and then with water; the organic phase is dried, decolorised and evaporated in vacuo. An oil remains, which crystallises gradually. The ester is recrystallized from 75 cm3 of hexane and 6.8 g of expected product are obtained. Melting point 57 C.
		Example 4 Fenofibrate Formulations Containing Poloxamer 407 and NaCMC
		(3) Overcoating with HPMC 606/talc The assembly is carried out in a fluidized bed to obtain a fenofibrate content of the microgranules greater than 600 mg/g.
		EXAMPLE 8: Surfactant polysorbate 20 was mixed with lipophilic phase isopropyl myristate and heated to 80 C. Fenofibrate was added, allowed to melt and clear SMES was formed.
		(Comparative Example 4) Pulverization of fenofibrate was performed in the same manner as in Comparative Example 1. The average particle diameter of the resulting fenofibrate was 1,377 nm.

6
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[ 42017-89-0 ]

Yield	Reaction Conditions	Operation in experiment
15%		Example 12 - Formula 139 - Compounds 12a & 12bIntermediate B: 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoic acid To a stirred solution of compound A (1 .0 g, 2.77 mmol) in THF (10 mL) was added LiOH-H20 (0.7 g, 16.6 mmol) and H20 (10 mL). The resulting mixture was heated at reflux overnight then quenched with a 1 M aqueous HCI solution and extracted with EtOAc (10 mL x 3). The combined organic layers were washed with brine, dried over MgS04 and concentrated under reduced pressure. The residue was purified by flash chromatography (CH2Cl2/MeOH, 15/1 , v/v) to give 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoic acid (130 mg, 15%) as a white solid.LC-MS (Agilent): Rt 3.00 min; m/z calculated for Ci7H15CI04 [M+H]+ 319.07, found 319.1 .
15%	With lithium hydroxide monohydrate; water; In tetrahydrofuran;Reflux;	To a stirred solution of compound A (1.0 g, 2.77 mmol) in THF (10 mL) was added LiOH.H2O (0.7 g, 16.6 mmol) and H2O (10 mL). The resulting mixture was heated at reflux overnight then quenched with a 1 M aqueous HCl solution and extracted with EtOAc (10 mL*3). The combined organic layers were washed with brine, dried over MgSO4 and concentrated under reduced pressure. The residue was purified by flash chromatography (CH2Cl2/MeOH, 15/1, v/v) to give 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoic acid (130 mg, 15%) as a white solid. LC-MS (Agilent): Rt 3.00 min; m/z calculated for C17H15ClO4 [M+H]+ 319.07. found 319.1.
	With sodium hydroxide; for 4h;Reflux;	NaOH (0.6 g, 15 mmol) was added to a stirred solutionof (4-chlorophenyl) (4-hydroxyphenyl) methanone (3.49 g,15 mmol) in dry 2-butanone (60 mL). The reaction mixturewas heated under reflux for 1 h and isopropyl-(2-bromo-2-methyl)-propanonate (3.76 g) in dry 2-butanone (15 mL)was then added. The reaction mixture was heated underreflux for 8 h until the reaction was complete. Subsequently,1 M NaOH 50 mL was added to the reaction, and theresulting mixture was heated under reflux for 4 h. Theresidue was partitioned between water with brine (20 mL)and CH2Cl2 (80 mL). The separated organic layer waswashed with brine (20 mL), dried over anhydrous sodiumsulfate, filtered, concentrated, and recrystallized withacetone to give fenofibric acid as a white powder (4.3 g,90%). 1H NMR (300 MHz, CDCl3) d 11.2 (s, 1H), 7.75-6.93(m, 8H), 1.70 (m, 6H).

Reference： [1]Tetrahedron Letters,2007,vol. 48,p. 2497 - 2499
[2]Acta Crystallographica, Section C: Crystal Structure Communications,2005,vol. 61,p. o81-o84
[3]Patent: WO2012/63085,2012,A2 .Location in patent: Page/Page column 83-84
[4]Patent: US2013/225594,2013,A1 .Location in patent: Paragraph 0268; 0269
[5]Photochemistry and Photobiology,2002,vol. 75,p. 193 - 200
[6]Biochemical Pharmacology,2004,vol. 67,p. 285 - 292
[7]Il Farmaco,2005,vol. 60,p. 425 - 438
[8]Crystal Growth and Design,2014,vol. 14,p. 3800 - 3812
[9]Drug Metabolism and Disposition,2015,vol. 43,p. 1815 - 1822
[10]Journal of the Brazilian Chemical Society,2020,vol. 31,p. 280 - 287

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[ 42019-78-3 ]
[ 49562-28-9 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium hydrogencarbonate; In isopropyl alcohol; for 48h;Heating / reflux;Purification / work up;	Example 1 200 g of 4-chloro-4-hydroxybenzofenone, potassium bicarbonate (156 g), 360 g of isopropyl alpha-bromo isobutyrate and isopropanol (400 ml) were charged in a round bottom flask. The mixture was heated to reflux temperature for 48 hours, with stirring. After reaction completion, the reaction mixture was cooled at about 60C, and isopropanol (560 ml), acetone (240 ml), and a decolorizing agent (4.5 g of activated carbon) were added. The suspension was further cooled to about 40C, and stirring was continued for about 30 minutes. The suspension was filtered, and the solid was washed on the filter with a mixture of isopropanol and acetone. The filtrate was let to stand overnight at room temperature, and then stirred for additional 3-4 hours at 0-5C. Precipitated pure fenofibrate was filtered, washed on the filter with isopropanol and water. The compound was collected from the filter and dried at about 60 for 12 hours, to yield 220 g of pure fenofibrate.

Reference： [1]Journal of the American Chemical Society,2017,vol. 139,p. 2896 - 2899
[2]Chemical Communications,2018,vol. 54,p. 10989 - 10992
[3]Organometallics,2016,vol. 35,p. 3378 - 3387
[4]Patent: EP1837327,2007,A1 .Location in patent: Page/Page column 4

8
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Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate; In water;	PREPARATlON VI (Example 1) Preparation of the 1-methylethyl ester of 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoic acid (fenofibrate) 100 g (0.43 mol) of (4-chlorophenyl)(4-hydroxyphenyl)methanone and 165 g (0.79 mol) of the 1-methylethyl ester of 2-bromo-2-methylpropanoic acid are introduced, under a nitrogen atmosphere, into a 3-necked round-bottomed flask equipped with a stirrer and a condenser. The reaction medium is heated to 110° C. and a solution of 50 g (0.36 mol) of potassium carbonate in 50 ml of demineralized water is then added slowly over a period of 20 minutes, with distillation taking place at 100° C. The distillate separates out into 2 phases. The lower phase is recycled into the reaction medium. After heating at 110°-112° C. for 1.5 h, the reaction medium is brought to 140° C. and a temperature of 140°-145° C. is maintained for 4 hours. The reaction medium is then cooled to about 90° C. and 210 ml of 80percent isopropyl alcohol are added. The mixture is then left to cool for 12 h, with stirring, after which the suspension obtained is filtered at 0° C. The precipitate is washed with 4 times 200 ml of demineralized water and then recrystallized from propan-2-ol to give 119.5 g (yield=77percent) of fenofibrate.

Reference： [1]Patent: US4739101,1988,A
[2]Patent: FR2300552,1976,
Patent: DE2605382,1976,
Chem.Abstr.,1976,vol. 85

9
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[ 54419-31-7 ]

Reference： [1]Patent: FR2300552,1976,
Patent: DE2605382,1976,
Chem.Abstr.,1976,vol. 85

10
[ 49562-28-9 ]
fenofibric acid sodium salt [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydroxide; In ethanol; at 20℃;	To about 50 ml of ethanol 10-gm <strong>[49562-28-9]fenofibrate</strong> crystals, and a molar equivalent of NaOH are added while stirring at room temperature. After the mixture turns into a solution, it is taken to dryness in vacuo to yield the sodium salt of the free acid form of <strong>[49562-28-9]fenofibrate</strong> hereinafter referred to as Compound II.

Reference： [1]Patent: US2005/101561,2005,A1 .Location in patent: Page/Page column 9

11
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[ 5470-11-1 ]
[ 1204407-36-2 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2009,vol. 19,p. 6986 - 6990

12
[ 49562-28-9 ]
[ 119-26-6 ]
isopropyl 2-(4-((4-chlorophenyl)(2-(2,4-dinitrophenyl)hydrazono)methyl)phenoxy)-2-methylpropanoate [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2009,vol. 19,p. 6986 - 6990

13
[ 42017-89-0 ]
[ 75-26-3 ]
[ 49562-28-9 ]

Yield	Reaction Conditions	Operation in experiment
94.9%		Example I 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid, 1-methylethyl ester 1 kg (3.14 mol) of <strong>[42017-89-0]fenofibric acid</strong> (II), 500 ml of dimethyl sulfoxide and 1 l of isopropyl acetate were charged into a jacketed 5 l reactor under nitrogen. 433.5 g (3.14 mol) of potassium carbonate were then added, with stirring at ambient temperature, and the reaction mixture was brought to 85-90 C. for 45 min. The temperature of the reaction mixture was subsequently reduced to approximately 80 C. and 354 ml (3.77 mol) of 2-bromopropane and then 100 ml of isopropyl acetate were added over a period of 50 min. The mixture was kept stirring at 85-95 C. for 5 hours and then slightly cooled to approximately 80 C. In-process monitoring showed that the degree of conversion to give fenofibrate was approximately 99.5%.

Reference： [1]Patent: US2012/65421,2012,A1 .Location in patent: Page/Page column 2-3

14
[ 49562-28-9 ]
[ 72577-81-2 ]

Reference： [1]Patent: WO2012/63085,2012,A2
[2]Patent: US2013/225594,2013,A1
[3]New Journal of Chemistry,2019,vol. 43,p. 15793 - 15796

15
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[ 1376615-21-2 ]

Reference： [1]Patent: WO2012/63085,2012,A2
[2]Patent: US2013/225594,2013,A1
[3]New Journal of Chemistry,2019,vol. 43,p. 15793 - 15796

16
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[ 1376615-23-4 ]

Reference： [1]Patent: WO2012/63085,2012,A2
[2]Patent: US2013/225594,2013,A1

17
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[ 1428245-12-8 ]
[ 1428245-13-9 ]

Reference： [1]Organic and Biomolecular Chemistry,2013,vol. 11,p. 2318 - 2322

18
[ 49562-28-9 ]
[ 133745-75-2 ]
[ 1453101-23-9 ]

Yield	Reaction Conditions	Operation in experiment
75%	With [Ag(2,2'-bipyridine)2](ClO4); C20H28N4O2Pd(2+)*2CF3O3S(1-); In acetonitrile; at 23℃; for 24h;Inert atmosphere; Sealed tube;	Under N2 atmosphere, an oven-dried 4 mL vial was charged <strong>[49562-28-9]Fenofibrate</strong> (isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate) (108.2 mg, 0.300 mmol, 1.00 equiv), palladium complex 1 (11.4 mg, 15.0 muiotaetaomicron, 5.00 mol%), Ag(bipy)2C104 (16.0 mg, 30.0 muetaiotaomicron, 10.0 mol%), and NFBS (0.189 g, 0.600 mmol, 2.00 equiv). Acetonitrile (0.75 mL, c = 0.40 M) was added and the reaction mixture was stirred in a sealed vial at 23 C for 24 h. Subsequently, triethylamine (30.5 mg, 42.0 mu, 0.300 mmol, 1.00 equiv) was added and the reaction mixture was concentrated in vacuo. The residue was purified by chromatography on silica gel, eluting with hexanes/EtOAc (19: 1 to 5.7: 1 (v/v) with 1% triethylamine), to afford 148.4 mg of the title compound as a colorless solid (75% yield). [00258] R/= 0.57 (hexanes/EtOAc 7:3 (v/v)). NMR Spectroscopy: 1H NMR (600 MHz, CDC13, 23 C, delta): 8.01-8.04 (m, 4H), 7.86 (dd, J = 8.8, 2.3 Hz, 1H), 7.68-7.70 (m, 2H), 7.64-7.68 (m, 2H), 7.56 (d, J = 2.3 Hz, 1H), 7.53-7.56 (m, 4H), 7.43-7.46 (m, 2H), 6.70 (d, J = 8.8 Hz, 1H), 5.07 (sep, J = 6.3 Hz, 1H), 1.34 (s, 6H), 1.25 (d, J = 6.5 Hz, 6H). 13C NMR (125 MHz, CDCI3, 23 C, delta): 192.8, 172.6, 158.0, 140.4, 138.9, 136.0, 135.7, 133.8, 133.1, 131.3, 129.8, 129.0, 129.0, 128.8, 124.4, 115.9, 80.5, 69.5, 24.3, 21.7. Mass Spectrometry: HRMS (ESI-TOF) (m/z): calcd for C32H34C1N208S2 ([M + NH4]+), 673.144, found, 673.1455.

Reference： [1]Journal of the American Chemical Society,2013,vol. 135,p. 13278 - 13281
[2]Patent: WO2015/31725,2015,A1 .Location in patent: Paragraph 00257; 00258

19
[ 1375008-18-6 ]
[ 1679-18-1 ]
[ 82102-37-2 ]
[ 49562-28-9 ]

Reference： [1]Journal of Organic Chemistry,2013,vol. 78,p. 10310 - 10318

20
[ 1581307-35-8 ]
[ 5123-08-0 ]
[ 82102-37-2 ]
[ 49562-28-9 ]

Reference： [1]Organic Letters,2014,vol. 16,p. 1888 - 1891

21
[ 49562-28-9 ]
[ 1610958-42-3 ]

Yield	Reaction Conditions	Operation in experiment
90%	With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; d8-isopropanol; potassium carbonate; bis(dibenzylideneacetone)-palladium(0); In acetonitrile; at 100℃; for 2.5h;Inert atmosphere; Microwave irradiation;	General procedure: In a dried microwave reactor vessel were added 3-bromoquinoline(0.204 mL, 1.5 mmol), Pd(dba)2 (86 mg, 0.15 mmol), K2CO3carbonate (415 mg, 3.00 mmol), S-Phos (185 mg, 0.45 mmol), dryD8-IPA (0.500 mL) and MeCN (1 mL). The mixture was degassedand placed under a nitrogen atmosphere. The sealed reaction tubewas heated to 100 C in a microwave (Biotage Initiator) for 2.5 h.The solvents were removed under reduced pressure, the crudematerial pre-loaded on to silica and purified using flash silica chromatography(15% EtOAc/heptane). The fractions containing thedesired compound were combined and evaporated to dryness toafford 3-deuterioquinoline (140 mg, 72%); 1H NMR (400 MHz,DMSO, 27 C): d (ppm) 7.62 (ddd, J = 1.20, 6.89, 8.11 Hz, 1H), 7.77(ddd, J = 1.50, 6.87, 8.43 Hz, 1H), 7.99 (dd, J = 1.33, 8.18 Hz, 1H),8.03 (d, J = 8.41 Hz, 1H), 8.37 (s, 1H), 8.91 (d, J = 1.70 Hz, 1H); 13CNMR (176 MHz, DMSO, 30 C) 121.0, 126.4, 127.8, 128.0, 128.8,129.3, 135.8, 147.7, 150.3; HRMS (EI): M+, found 130.0643,C9H6DN requires 130.0641.

Reference： [1]Journal of Organic Chemistry,2016,vol. 81,p. 8934 - 8946
[2]Tetrahedron Letters,2014,vol. 55,p. 3305 - 3307

22
[ 10359-09-8 ]
[ 1581307-35-8 ]
[ 49562-28-9 ]

Reference： [1]IUBMB Life,2014,vol. 356,p. 3659 - 3667
[2]Advanced Synthesis and Catalysis,2014,vol. 356,p. 3659 - 3667

23
C₂₃H₂₇ClO₃S₂ [ No CAS ]
[ 49562-28-9 ]

Reference： [1]IUBMB Life,2014,vol. 356,p. 3659 - 3667
[2]Advanced Synthesis and Catalysis,2014,vol. 356,p. 3659 - 3667

24
[ 49562-28-9 ]
[ 75-08-1 ]
isopropyl 2-(4-((4-chlorophenyl)bis(ethylmercapto)methyl)phenoxy)-2-methylpropionate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
12.4 g	With boron trifluoride diethyl etherate; at 0℃; for 1h;	10 g isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropionate was dissolved in 12ml ethanethiol, and then 8.7 ml boron trifluoride etherate solution was slowly added dropwise at 0C. After the dropping was complete, the stirring was continued for 1 h, until the reaction was complete. And then, it was quenched with satutrated sodium bicarbonate, and extracted with ethyl acetate. The organic phase was successively washed with satutrated sodium bicarbonate, water, and satutrated saline solution, dried, and concentrated, and the crude product was subjected to column chromatography (petroleum ether : ethyl acetate / 50:1), in order to obtain 12.4 g product. 1H NMR (400MHz, CDCl3) delta: 1.05 (t, J =7.6Hz, 6H), 1.20 (d, J =6.4Hz, 6H), 1.59 (s, 6H), 2.25-2.33 (m, 4H), 5.04-5.11 (m, 1H), 6.74 (d, J=8.8Hz, 2H), 7.24 (d, J=8.8Hz, 2H), 7.36 (d, J=8.8Hz, 2H), 7.46 (d, J=8.8Hz, 2H); ESI-MS (m/z): 489.5 (M+Na+)
12.4 g	With boron trifluoride diethyl etherate; at 0℃; for 1h;	10 g of isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropionate was dissolved in 12 ml of ethanethiol, and then 8.7 ml of boron trifluoride etherate solution was slowly added dropwise at 0 C. After the dropping was complete, the stirring was continued for 1 h, until the reaction was complete. And then, it was quenched with satutrated sodium bicarbonate, and extracted with ethyl acetate. The organic phase was successively washed with satutrated sodium bicarbonate, water, and satutrated saline solution, dried, and concentrated, and the crude product was subjected to column chromatography (petroleum ether:ethyl acetate/50:1), 12.4 g of the title product is obtained. 1H NMR (400 MHz, CDCl3) delta: 1.05 (t, J=7.6 Hz, 6H), 1.20 (d, J=6.4 Hz, 6H), 1.59 (s, 6H), 2.25-2.33 (m, 4H), 5.04-5.11 (m, 1H), 6.74 (d, J=8.8 Hz, 2H), 7.24 (d, J=8.8 Hz, 2H), 7.36 (d, J=8.8 Hz, 2H), 7.46 (d, J=8.8 Hz, 2H); ESI-MS (m/z): 489.5 (M+Na+).

Reference： [1]Patent: EP2842931,2015,A1 .Location in patent: Paragraph 0050; 0051
[2]Patent: US2015/119458,2015,A1 .Location in patent: Paragraph 0105-0107

25
[ 49562-28-9 ]
isopropyl 2-(4-((4-chlorophenyl)difluoromethyl)phenoxy)-2-methylpropionate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With (bis-(2-methoxyethyl)amino)sulfur trufluoride; at 90℃; for 24h;Inert atmosphere;	Bis(2-methoxyethyl)amine sulfur trifluoride was added into isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropionate under the protection of argon, the reaction system was heated to 90C, and the reaction was kept for 24 h with stirring, the reaction liquid was cooled to room temperature, diluted with methylene dichloride, washed with saturated sodium bicarbonate solution and saturated saline solution, respectively, and the organic phase was dried and then subjected to column chromatography (petroleum ether : ethyl acetate / 50:1), in order to obtaine the desired compound isopropyl 2-(4-((4-chlorophenyl)difluoromethyl)phenoxy)-2- methylpropionate. ESI-MS (m/z): 405.0 (M+Na+), 383.0 (M+H+)

Reference： [1]Patent: EP2842931,2015,A1 .Location in patent: Paragraph 0054; 0055
[2]Patent: US2015/119458,2015,A1

26
[ 49562-28-9 ]
sodium 2-(4-((4-chlorophenyl)difluoromethyl)phenoxy)-2-methylpropionate [ No CAS ]

Reference： [1]Patent: EP2842931,2015,A1
[2]Patent: EP2842931,2015,A1
[3]Patent: US2015/119458,2015,A1

27
[ 49562-28-9 ]
2-(4-((4-chlorophenyl)difluoromethyl)phenoxy)-2-methylpropionic acid [ No CAS ]

Reference： [1]Patent: EP2842931,2015,A1
[2]Patent: EP2842931,2015,A1
[3]Patent: US2015/119458,2015,A1

28
[ 49562-28-9 ]
tetramethylammonium trifluoromethanethiolate [ No CAS ]
isopropyl 2-methyl-2-(4-(4-((trifluoromethyl)thio)benzoyl)phenoxy)propanoate [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2015,vol. 137,p. 4164 - 4172

29
[ 49562-28-9 ]
[ 71-36-3 ]
C₂₄H₃₁ClO₄ [ No CAS ]

Reference： [1]Organic Letters,2015,vol. 17,p. 1778 - 1781

30
[ 201230-82-2 ]
[ 1375008-18-6 ]
potassium (4-chlorophenyl)trifluoroborate [ No CAS ]
[ 49562-28-9 ]

Reference： [1]Chemical Communications,2015,vol. 51,p. 9133 - 9136

31
[ 1120-64-5 ]
[ 49562-28-9 ]
(2-acetoxyethylamino)fenofibrate [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2015,vol. 137,p. 9816 - 9819

32
[ 637-87-6 ]
2-(4-((1-isopropoxy-2-methyl-1-oxopropan-2-yl)oxy)phenyl)-2-oxoacetic acid [ No CAS ]
[ 49562-28-9 ]

Yield	Reaction Conditions	Operation in experiment
71%	With [nickel(II)dichloride(dimethoxyethane)]; Ir[dF(CF3)ppy]2(dtbbpy)PF6; lithium carbonate; 4,4'-di-tert-butyl-2,2'-bipyridine; In water; N,N-dimethyl-formamide; for 96h;Inert atmosphere; Sealed tube; Microwave irradiation;	XAMPLE 49 - FenofibrateAn oven-dried 40 mL vial equipped with a Teflon septum cap and magnetic stir bar was charged with Ir[dF(CF3)ppy]2(dtbbpy)PF6 (11.2 mg, 0.01 mmol, 0.02 equiv), NiCl2-glyme (11.2 mg, 0.05 mmol, 0.10 equiv), 4,4'-di-terf-butyl-2,2'-bipyridine (20.1 mg, 0.075 mmol, 0.15 equiv), 2-(4-((l-isopropoxy-2-methyl-l-oxopropan-2-yl)oxy)phenyl)-2-oxoacetic acid (>95%, 310 mg, 1.00 mmol, 2.0 equiv), 4-chloro-l-iodobenzene (120 mg, 0.50 mmol, 1.0 equiv), and L12CO3 (73.9 mg, 1.00 mmol, 2.0 equiv) from a bottle stored in a dessicator. To this vial was added DMF (25 mL) and water (18 mu, 2.00 mmol, 2.0 equiv). The reaction mixture was degassed for 30 minutes by bubbling argon stream, then sealed with parafilm. The vial was irradiated with 34W Blue LED lamp (Kessil KSH150B LED Grow Light) for 72 hours with cooling from a fan (vial temperature reached 37 C). After 96 hours, the reaction was diluted with 25 mL 0 and extracted with 3x75 mL E12O. The combined organic layers were washed with 3x25 mL 0, then dried over MgSC>4, filtered, and concentrated in vacuo. The crude product was purified by flash chromatography on silica gel with a 25g column on a biotage instrument with 5% EtOAc in hexanes as eluent, to yield 40 as an off-white solid 127,9 mg, 71% yield. NMR (501 MHz, Chloroform- J) delta 7.72 (d, J= 8.8 Hz, 2H), 7.69 (d, J= 8.4 Hz, 2H), 7.44 (d, J= 8.4 Hz, 2H), 6.86 (d, J= 8.8 Hz, 2H), 5.08 (hept, = 6.3 Hz, 1H), 1.65 (s, 6H), 1.20 (d, .7= 6.3 Hz, 6H). 13C NMR (126 MHz, CDCI3) delta 194.4, 173.2, 159.9, 138.5, 136.5, 132.1, 131.3, 130.3, 128.7, 117.4, 79.5, 69.5, 25.5, 21.7.

Reference： [1]Angewandte Chemie - International Edition,2015,vol. 54,p. 7929 - 7933
Angew. Chem.,2015,vol. 127,p. 8040 - 8044,5
[2]Patent: WO2015/153381,2015,A2 .Location in patent: Page/Page column 42

33
[ 99-93-4 ]
[ 49562-28-9 ]

Reference： [1]Angewandte Chemie - International Edition,2015,vol. 54,p. 7929 - 7933
Angew. Chem.,2015,vol. 127,p. 8040 - 8044,5

34
[ 51368-55-9 ]
[ 49562-28-9 ]

Reference： [1]Angewandte Chemie - International Edition,2015,vol. 54,p. 7929 - 7933
Angew. Chem.,2015,vol. 127,p. 8040 - 8044,5

35
[ 49562-28-9 ]
[ 98-16-8 ]
isopropyl 2-methyl-2-(4-(4-((3-(trifluoromethyl)phenyl)amino)benzoyl)phenoxy)propanoate [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2016,vol. 55,p. 2531 - 2535
Angew. Chem.,2016,vol. 128,p. 2577 - 2581,5

36
[ 13061-96-6 ]
[ 49562-28-9 ]
isopropyl 2-methyl-2-(4-(4-methylbenzoyl)phenoxy)propanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
76%	With 1,2,3-trimethoxybenzene; O4P(3-)3K(1+)5H2O; tris(1-adamantyl)phosphine; {2-[((acetyl-kappaO)amino)phenyl-kappaC](tri-1-adamantylphosphine)palladium}(p-toluenesulfonate); In tetrahydrofuran; toluene; at 100℃; for 5h;	To a mixture of <strong>[49562-28-9]fenofibrate</strong> (90 mg, 0.25 mmol, 1 equiv), methylboronic acid (30 mg, 0.50 mmol, 2 equiv), 1,3,5-trimethyoxybenzene (42 mg, 0.25 mmol, 1 equiv) as internal standard, and K3P04H20 (0.18 g, 0.75 mmol, 3 equiv) was added toluene (400 iL) then a THF stock solution of 3 and PAd3 (50 1iL, 0.125 iimol of Pd/PAd3), The mixture was stirred at 100 Cfor 5 h. The crude NMR yield was 88 % versus internal standard. The reaction mixture was diluted with ethyl acetate then extracted with water. The combine organic layers were evaporated and the crude product was purified by flash chromatography and preparative HPLC. After drying, 65 mg (76%) of 42 was obtained as a white solid.?H NMR (501 MHz, CDC13) oe 7.80- 7.73 (m, 2H), 7.71 - 7.65 (m, 2H), 7.28 (d, J 7.9 Hz,2H), 6.92 - 6.84 (m, 2H), 5.10 (hept, J= 6.3 Hz, 1H), 2.44 (s, 3H), 1.67 (s, 6H), 1.22 (d, J= 6.3Hz, 6H).?3C{?H} NMR (126 MHz, CDC13) oe 195.3, 173.2, 159.3, 142.7, 135.4, 131.9, 130.9, 130.0, 128.9, 117.1, 79.3, 69.3, 25.4, 21.6, 21.5.HRMS (ESI) mlz calculated for C21H2404 (M+1) 341.1747, found 341.1749.

Reference： [1]Journal of the American Chemical Society,2016,vol. 138,p. 6392 - 6395
[2]Patent: WO2017/75581,2017,A1 .Location in patent: Page/Page column 31; 32

37
[ 49562-28-9 ]
[ 411235-57-9 ]
C₂₃H₂₆O₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
92%	With potassium phosphate monohydrate; tris(1-adamantyl)phosphine; {2-[((acetyl-kappaO)amino)phenyl-kappaC](tri-1-adamantylphosphine)palladium}(p-toluenesulfonate); In tetrahydrofuran; toluene; at 100℃; for 5h;Inert atmosphere;	To a mixture of <strong>[49562-28-9]fenofibrate</strong> (90 mg, 0.25 mmol, 1 equiv), cyclopropylboronic acid (32 mg, 0.38 mmol, 1.5 equiv), and K3P04?H20 (0.18 g, 0.75 mmol, 3 equiv) was added toluene(400 pL) then a THF stock solution of 3 and PAd3 (50 tL, 0.125 jimol of Pd/PAd3). The mixturewas stirred at 100 C for 5 h. The reaction mixture was diluted with ethyl acetate then extractedwith water. The combine organic layers were evaporated and the crude product was purified byflash chromatography. After drying, 84 mg (92 %) of 15 was obtained as a white solid.1H NMR (501 MHz, CDC13) oe 7.80- 7.72 (m, 2H), 7.72 - 7.66 (m, 2H), 7.19-7.12 (m, 2H),6.91 -6.84 (m, 2H), 5.11 (hept, J 6.3 Hz, 1H), 1.99 (tt, J- 8.4, 5.0 Hz, 1H), 1.68 (s, 6H), 1.23(d, J- 6.3 Hz, 6H), 1.13- 1.05 (m, 2H), 0.85-0.78 (m, 2H).?3c{?H} NMR (126 MHz, CDC13) 195.2, 173.2, 159.3, 149.2, 135.2, 131.9, 131.0, 130.1, 125.2, 117.1, 79.3, 69.3, 25.4, 21.5, 15.7, 10.3.HRMS (ESI) m/z calculated for C23H2604 (M+1) 367.1904, found 367.1888.

Reference： [1]Journal of the American Chemical Society,2016,vol. 138,p. 6392 - 6395
[2]Patent: WO2017/75581,2017,A1 .Location in patent: Page/Page column 19

38
[ 49562-28-9 ]
[ 84476-99-3 ]
isopropyl 2-(4-(4-(2,5-difluoropyridin-4-yl)benzoyl)phenoxy)-2-methylpropanoate [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2016,vol. 55,p. 10463 - 10467
Angew. Chem.,2016,vol. 128,p. 10619 - 10623,5

39
[ 49562-28-9 ]
[ 140681-55-6 ]
C₂₄H₂₉ClN₂O₄ [ No CAS ]

Reference： [1]Nature Chemistry,2016,vol. 8,p. 810 - 815

40
[ 49562-28-9 ]
[ 140681-55-6 ]
C₂₇H₃₄Cl₂N₂O₄⁽²⁺⁾*2BF₄^(1-) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
88%	With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; C20H28N4O2Pd(2+)*2BF4(1-); In acetonitrile; at 23℃; for 24h;	General procedure: A 100 ml pressure tube was charged with palladium complex 1 (13.6 mg, 21.4 mumol, 2.50 mol%), Ru(bipy)3(PF6)2 (55.2 mg, 64.2 mumol, 7.50 mol%) and <strong>[140681-55-6]Selectfluor</strong> (455 mg, 1.28 mmol, 1.50 equiv.). Acetonitrile (4.3 ml, 0.20 M) was added, followed by toluene (91.1 mul, 0.856 mmol, 1.00 equiv.) via a syringe. The reaction mixture was stirred at 23 C for 24 hours. Saturated aqueous sodium thiosulfate (8.6 ml) and water (8.6 ml) were added, the pressure tube was sealed and the reaction mixture was stirred at 100 C for two hours. After cooling to 23 C, the reaction mixture was transferred to a separatory funnel. Dichloromethane (20 ml) and ethylenediamine (1.5 ml) were added and the organic layer was washed with 6 M aqueous sodium hydroxide (5 ml). The aqueous layer was extracted with dichloromethane (2 × 10 ml). The combined organic layers were extracted with 1 M aqueous hydrochloric acid (2 × 15 ml). Ethylenediamine (5.0 ml) was added to the combined acidic aqueous layers, followed by basification with 6 M aqueous sodium hydroxide (8 ml). The basic aqueous layer was extracted with dichloromethane (3 × 15 ml). The combined organic layers were dried over sodium sulfate, filtered and concentrated in vacuo to afford a red oil. The residue was purified by chromatography on silica gel, eluting with a solvent mixture of dichloromethane/methanol/28% aqueous ammonium hydroxide (97.5/2.0/0.5 v/v/v) to afford 119 mg of the title compound as a yellow oil (79% yield).

Reference： [1]Nature Chemistry,2016,vol. 8,p. 810 - 815

41
C₁₉H₂₃ClO₂Si [ No CAS ]
[ 49562-28-9 ]