Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 49655-93-8 | MDL No. : | MFCD09258913 |
Formula : | C8H6N2O2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 162.15 | Pubchem ID : | - |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362 | UN#: | N/A |
Hazard Statements: | H315-H319 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
80% | With sulfuric acid; sodium nitrite; at 30℃; for 0.166667h; | 2-Amino-7-hydroxy-l,8-naphthyridine (10?g, 62?mmol) was ground to a fine powder and added to concentrated sulfuric acid (80?mL), and then sodium nitrite (5?g, 74?mmol) was added. The mixture was allowed to stand for 10?min, poured over crushed ice, and allowed to stand for 10?min. Excess acid was neutralized with sodium carbonate, and then the solution was acidified with glacial acetic acid (pH?=?3), giving 2,7-dihydroxy-1,8-naphthyridine as a brown powder. Yield?=?8?g (80%). 1H NMR (500?MHz, DMSO-d6): delta?=?7.54 (d, J?=?8.9?Hz, 2H), 5.98 (d, J?=?9.1?Hz, 2H), 3.31?ppm (brs, 2H); 13C NMR (126?MHz; DMSO-d6): delta?=?166.2, 149.8, 139.4, 112.6, 102.0?ppm; MS (ESI; CH3OH): m/z 163.05 ([M+H]+). |