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[ CAS No. 509094-02-4 ] {[proInfo.proName]}

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Chemical Structure| 509094-02-4
Chemical Structure| 509094-02-4
Structure of 509094-02-4 * Storage: {[proInfo.prStorage]}
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Product Details of [ 509094-02-4 ]

CAS No. :509094-02-4 MDL No. :MFCD13248593
Formula : C13H18N2O3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 250.29 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 509094-02-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 509094-02-4 ]

[ 509094-02-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 20274-69-5 ]
  • [ 108-91-8 ]
  • [ 509094-02-4 ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; In ethyl acetate; (a) A mixture of <strong>[20274-69-5]4-fluoro-3-nitrobenzyl alcohol</strong> (prepared as in Example 29 above, 14.2 g, 82.9 mmol), cyclohexylamine (8.22 g, 82.9 mmol) and N,N-diisopropylethylamine (10.7 g, 82.8 mmol) was heated to 60 C. for 4 hr with vigorous stirring. The reaction mixture was then cooled, and ethyl acetate (400 mL) was added. The solution was then extracted with water (2*100 mL), dried over magnesium sulphate and evaporated to afford 4-cyclohexylamino-3-nitrobenzyl alcohol as an orange oil.
With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 130℃; for 0.116667h;Microwave irradiation; Example 16; (1-cyclohexyl-2-(5-(4-methoxypyridin-3-yl)-1H-indazol-3-ylamino)-1H-benzo[d]imidazol-5-yl)methanol; Step 1: (4-Cyclohexylamino-3-nitro-phenyl)methanol; A mixture of (4-Fluoro-3-nitrophenyl)methanol (1.00 g, 0.0058 mol), N,N-diisopropylethylamine (2.036 mL, 0.0117) and cyclohexanamine (2.005 mL, 0.0175 mol) in N,N-Dimethylformamide (2.46 mL) was placed in a microwave vial, the contents were mixed thoroughly then microwaved at 130 C. for 7 minutes. The resultant gel was dissolved in ethyl acetate then washed with 5% citric acid, brine, dried and concentrated to give the title compound.
  • 2
  • [ 114615-82-6 ]
  • [ 509094-02-4 ]
  • [ 70187-32-5 ]
  • [ 509094-03-5 ]
YieldReaction ConditionsOperation in experiment
In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran 32.b Example 32 (b) To a solution of 4-cyclohexylamino-3-nitrobenzyl alcohol (21.0 g, 83 mmol) in DCM (300 mL) was added powdered 4 Å molecular sieves (15 g) and N-methyl morpholine-N-oxide monohydrate (10.8 g, 92.2 mmol). Tetra-n-propylammonium perruthenate (VII) (2.91 g, 8.28 mmol) was then added in a single portion. An initial exotherm was controlled using an ice bath, and then the reaction mixture was stirred at room temperature for 18 hr. The mixture was then reduced to ~100 mL by evaporation, and loaded onto a column of silica (400 g). The column was eluted with acetone:hexane 1:3 and the spot at 0.30 was collected, affording 4-cyclohexylamino-3-nitrobenzaldehyde as a yellow solid. (11.0 g, 44.3 mmol): 1H NMR (CDCl3, 300 MHz) δ9.60 (s, 1 H), 8.32 (s, 1 H), 7.71 (d, J=10 Hz,1 H), 6.73 (d, J=10 Hz, 1 H) 3.46-3.32 (m, 1 H), 1.90-1.15 (m, 10 H).
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