Alternatived Products of [ 509094-02-4 ]
Product Details of [ 509094-02-4 ]
CAS No. : | 509094-02-4 |
MDL No. : | MFCD13248593 |
Formula : |
C13H18N2O3
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
250.29
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 509094-02-4 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 509094-02-4 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 509094-02-4 ]
- 1
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[ 20274-69-5 ]
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[ 108-91-8 ]
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[ 509094-02-4 ]
Yield | Reaction Conditions | Operation in experiment |
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With N-ethyl-N,N-diisopropylamine; In ethyl acetate; |
(a) A mixture of <strong>[20274-69-5]4-fluoro-3-nitrobenzyl alcohol</strong> (prepared as in Example 29 above, 14.2 g, 82.9 mmol), cyclohexylamine (8.22 g, 82.9 mmol) and N,N-diisopropylethylamine (10.7 g, 82.8 mmol) was heated to 60 C. for 4 hr with vigorous stirring. The reaction mixture was then cooled, and ethyl acetate (400 mL) was added. The solution was then extracted with water (2*100 mL), dried over magnesium sulphate and evaporated to afford 4-cyclohexylamino-3-nitrobenzyl alcohol as an orange oil. |
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With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 130℃; for 0.116667h;Microwave irradiation; |
Example 16; (1-cyclohexyl-2-(5-(4-methoxypyridin-3-yl)-1H-indazol-3-ylamino)-1H-benzo[d]imidazol-5-yl)methanol; Step 1: (4-Cyclohexylamino-3-nitro-phenyl)methanol; A mixture of (4-Fluoro-3-nitrophenyl)methanol (1.00 g, 0.0058 mol), N,N-diisopropylethylamine (2.036 mL, 0.0117) and cyclohexanamine (2.005 mL, 0.0175 mol) in N,N-Dimethylformamide (2.46 mL) was placed in a microwave vial, the contents were mixed thoroughly then microwaved at 130 C. for 7 minutes. The resultant gel was dissolved in ethyl acetate then washed with 5% citric acid, brine, dried and concentrated to give the title compound. |
- 2
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[ 114615-82-6 ]
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[ 509094-02-4 ]
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[ 70187-32-5 ]
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[ 509094-03-5 ]
Yield | Reaction Conditions | Operation in experiment |
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In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran |
32.b Example 32
(b) To a solution of 4-cyclohexylamino-3-nitrobenzyl alcohol (21.0 g, 83 mmol) in DCM (300 mL) was added powdered 4 Å molecular sieves (15 g) and N-methyl morpholine-N-oxide monohydrate (10.8 g, 92.2 mmol). Tetra-n-propylammonium perruthenate (VII) (2.91 g, 8.28 mmol) was then added in a single portion. An initial exotherm was controlled using an ice bath, and then the reaction mixture was stirred at room temperature for 18 hr. The mixture was then reduced to ~100 mL by evaporation, and loaded onto a column of silica (400 g). The column was eluted with acetone:hexane 1:3 and the spot at 0.30 was collected, affording 4-cyclohexylamino-3-nitrobenzaldehyde as a yellow solid. (11.0 g, 44.3 mmol): 1H NMR (CDCl3, 300 MHz) δ9.60 (s, 1 H), 8.32 (s, 1 H), 7.71 (d, J=10 Hz,1 H), 6.73 (d, J=10 Hz, 1 H) 3.46-3.32 (m, 1 H), 1.90-1.15 (m, 10 H). |