Home Cart 0 Sign in  

[ CAS No. 51708-72-6 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 51708-72-6
Chemical Structure| 51708-72-6
Structure of 51708-72-6 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 51708-72-6 ]

Related Doc. of [ 51708-72-6 ]

Alternatived Products of [ 51708-72-6 ]

Product Details of [ 51708-72-6 ]

CAS No. :51708-72-6 MDL No. :MFCD19232042
Formula : C5H8Cl2O Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 155.02 Pubchem ID :-
Synonyms :

Safety of [ 51708-72-6 ]

Signal Word:Danger Class:8,6.1
Precautionary Statements:P260-P280-P284-P305+P351+P338-P310 UN#:2922
Hazard Statements:H302-H314-H330 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 51708-72-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 51708-72-6 ]

[ 51708-72-6 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 1679-47-6 ]
  • [ 51708-72-6 ]
YieldReaction ConditionsOperation in experiment
80% With thionyl chloride; zinc(II) chloride at 65℃; for 65h;
With hydrogenchloride; thionyl chloride
With hydrogenchloride; thionyl chloride for 504h;
With thionyl chloride; zinc(II) chloride
With thionyl chloride 1.A A. A. 2-Methyl-4-chlorobutyric acid chloride To a stirring solution of 77 g of α-methyl-γ-butyrolactone and 1 g of zinc chloride was added 120 g of thionyl chloride. The reaction was allowed to stir at room temperature for about 16 hours and then was heated to 75°-80° C. for 24 hours. The reaction mixture was distilled at 10 mm pressure to provide 2-methyl-4-chlorobutyric acid chloride. bp=57°-60° C.
With thionyl chloride; zinc(II) chloride at 80℃; for 15h; 22.22a Example 22; 1- (4-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-2- hydroxypropanoyl} piperazin-1-yl)-3-methylpyrrolidin-2-one; 22a) 1-(4-Benzylpiperazin-1-yl)-3-methylpyrrolidin-2-one; A mixture of 3-methyldihydrofuran-2 (3H)-one g), thionyl chloride (1.5 ml) and zinc chloride (10 mg) was stirred at 80°C for 15 hours. The mixture was cooled to room temperature, and the reaction mixture was added dropwise to a solution of 4-benzylpiperazin-1-amine (3.8 g) in THF (50 mL) at 0°C, followed by stirring at 0°C for 2 hours. Sodium hydride (60% in oil; 2.4 g) was added thereto and the mixture was stirred at room temperature for 15 hours. Ice was. added thereto, and then the reaction mixture was concentrated under reduced pressure. The residue was diluted with water, and extracted with dichloromethane. The extract was dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The residue obtained was purified by basic silica gel column chromatography (ethyl acetate/hexane = 1/5) to obtain the title compound (2.0 g, 37%) as a yellow oil. NMR (CDC13) 5: 1.18 (3H, d, J = 7.2), 1.48-1.63 (lH, m), 2.12-2.29 (lH, m), 2.28-2.49 (lH, m), 2.62 (4H, dd), 2.84- 3.08 (4H, m), 3.26-3.47 (2H, m), 3.48-3.64 (2H, m), 7.20- 7.40 (5H, m).

  • 2
  • [ 37551-43-2 ]
  • [ 51708-72-6 ]
  • [ 63483-13-6 ]
  • 3
  • [ 55809-36-4 ]
  • [ 51708-72-6 ]
  • 4-chloro-N-[5-(1,1-dimethylethyl)-3-isoxazolyl]-2-methylbutanamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
54% With triethylamine; In diethyl ether; ethyl acetate; toluene; B. 4-Chloro-N-[5-(1,1-dimethylethyl)-3-isoxazolyl]-2-methylbutanamide To a stirred solution of 7 g of 3-amino-5-(1,1-dimethylethyl)isoxazole and 5.05 g triethylamine dissolved in 100 ml ethyl acetate was added 7.75 g of 2-methyl-4-chlorobutyric acid chloride dropwise. The mixture was stirred for about 16 hours at room temperature and the precipitated salt was collected by filtration and washed with ethyl acetate. The filtrate was concentrated under reduced pressure and the residue was chromatographed over silica gel while eluding with a 1:1 (v/v) mixture of toluene:diethyl ether. Fractions containing the major component as indicated by thin layer chromatography were combined and concentrated under vacuum to provide 7 g of 4-chloro-N-[5-(1,1-dimethylethyl)-3-isoxazolyl]-2-methylbutanamide. Yield 54%. This material was used in the following reaction without additional purification.
  • 4
  • [ 59669-59-9 ]
  • [ 51708-72-6 ]
  • [ 92338-90-4 ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In ethyl acetate; A. 4-Chloro-N-[3-(1,1-dimethylethyl)-5-isoxazolyl]-2-methylbutanamide To a stirred solution of 7 g of <strong>[59669-59-9]3-(1,1-dimethylethyl)-5-aminoisoxazole</strong> dissolved in 50 ml ethyl acetate was added 5.05 g of triethylamine at room temperature. As the solution continued to stir, 8 g of 2-methyl-4-chlorobutyric acid chloride was added to the reaction mixture over a 15 minute period. The reaction was allowed to stir for about 3 days and the precipitated triethylamine hydrochloride salt was collected by filtration and washed with ethyl acetate. The solvent was evaporated from the filtrate under reduced pressure and the residue was recrystallized from diethyl ether to afford 4-chloro-N-[3-(1,1-dimethylethyl)-5-isoxazolyl]-2-methylbutanamide as a solid. mp 135°-137° C. Analysis calculated for C12 H19 ClN2 O2: Theory: C, 55.70; H, 7.40; N, 10.83. Found: C, 55.41; H, 7.15; N, 10.84.
  • 5
  • [ 51708-72-6 ]
  • [ 89151-73-5 ]
  • [ 92338-91-5 ]
YieldReaction ConditionsOperation in experiment
In toluene 3.A A. A. 4-Chloro-N-[3-(1,1-dimethylethyl)-5-isothiazolyl]-2-methylbutanamide To a solution of 2.4 g of 3-(1,1-dimethylethyl)-5-aminoisothiazole dissolved in 150 ml of toluene under nitrogen was added 2.3 g of 2-methyl-4-chlorobutyric acid chloride. The reaction mixture was refluxed for about 24 hours and cooled. The solvent was evaporated under reduced pressure, and the product was isolated from the residue by chromatography over silica gel eluding with an ethyl acetate/Skellysolve B solvent mixture. Fractions containing the major component were combined and the solvent was evaporated therefrom to afford, following crystallization from toluene/Skellysolve B, 0.5 g of 4-chloro-N-[3-(1,1-dimethylethyl)-5-isothiazolyl]-2-methylbutanamide.
  • 6
  • [ 39222-73-6 ]
  • [ 51708-72-6 ]
  • [ 554-68-7 ]
  • [ 57615-18-6 ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In ethyl acetate; EXAMPLE I SPC8 46.5 g (0.3 mole) of alpha-methyl-gamma-chlorobutyric acid chloride were added dropwise over the course of 30 minutes to a mixture of 47.1 g (0.3 mole) of 5-amino-2-tert.-butyl-1,3,4-thiadiazol and 30.3 g (0.3 mole) of triethylamine in 750 ml of anhydrous ethyl acetate at 20C. After stirring for 4 hours at 25C, the triethylammonium chloride formed was filtered off. The filtrate was freed from the solvent and the crystalline residue which remained was recrystallized from 75% strength aqueous methanol. This gave 66.6 g (81% of theory) of alpha-methyl-gamma-chlorobutyric acid N-(5-tert.-butyl-1,3,4-thiadiazol-2-yl)-amide of melting point 124.5-126C.
Same Skeleton Products
Historical Records