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[ CAS No. 52200-03-0 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 52200-03-0
Chemical Structure| 52200-03-0
Structure of 52200-03-0 *Storage: {[proInfo.prStorage]}

Quality Control of [ 52200-03-0 ]

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Alternatived Products of [ 52200-03-0 ]

Product Details of [ 52200-03-0 ]

CAS No. :52200-03-0MDL No. :MFCD09972170
Formula : C8H10O4S Boiling Point : -
Linear Structure Formula :-InChI Key :-
M.W :202.23Pubchem ID :-
Synonyms :

Computed Properties of [ 52200-03-0 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 52200-03-0 ]

Signal Word:WarningClass:N/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 52200-03-0 ]

  • Downstream synthetic route of [ 52200-03-0 ]

[ 52200-03-0 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 150-19-6 ]
  • [ 124-63-0 ]
  • [ 52200-03-0 ]
YieldReaction ConditionsOperation in experiment
90% With triethylamine In dichloromethane at 0 - 20℃; General procedure for synthesis of aryl mesylates General procedure: To a solution of phenol substrate (1.0 eq, 10.0 mmol) and Et3N (1.5 eq, 15.0 mmol) in CH2Cl2 (0.5 g/mL) was added dropwise the solution of MsCl (1.2 eq, 12.0 mmol) in CH2Cl2 at 0 oC. The mixture was allowed to warm to RT and stirred for 4 h-12 h to detect for the reaction completion. The reaction solution was added to H2O (20 ml). The layers were separated and the aqueous layer was extracted with CH2Cl2 (10 mL× 2). The combined organic layers were washed with brine (20 mL), and dried over Na2SO4. After the solvent was evaporated, the product was purified by column chromatography over silica gel.
85% With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;
84% With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;
With pyridine
With triethylamine In dichloromethane

  • 2
  • [ 17873-01-7 ]
  • [ 52200-03-0 ]
  • [ 24423-07-2 ]
YieldReaction ConditionsOperation in experiment
96% With tetrabutyl ammonium fluoride; palladium diacetate; XPhos In tetrahydrofuran; <i>tert</i>-butyl alcohol at 90℃; Inert atmosphere;
  • 4
  • [ 1891-90-3 ]
  • [ 52200-03-0 ]
  • [ 750607-55-7 ]
YieldReaction ConditionsOperation in experiment
91% With t-BuBrettPhos; water; palladium diacetate; caesium carbonate In <i>tert</i>-butyl alcohol at 110℃; for 0.233333h; Inert atmosphere;
  • 5
  • [ 905966-40-7 ]
  • [ 52200-03-0 ]
  • [ 81443-43-8 ]
YieldReaction ConditionsOperation in experiment
92% With potassium phosphate tribasic hydrate; NiIICl(1-naphthyl)(tricyclohexylphosphine)2; tricyclohexylphosphine; In tetrahydrofuran; at 23℃; for 1h;Inert atmosphere; Glovebox; Sealed tube; General procedure: Cross-Coupling of ortho-, meta-, and para-Substituted, Electron-Rich and Electron-Deficient Aryl Halides and Aryl Mesylates with Aryl Neopentylglycolboronates Catalyzed by NiIICl(1-naph-thyl)(PCy3)2/PCy3 in Anhydrous THF at 23 C; General Procedure 2In an oven-dried test tube charged with a Teflon coated stirring barwere added aryl halide or aryl mesylate (0.3 mmol), aryl neopentyl-glycolboronates (0.315 mmol), K3PO4(H2O)3.2 (191.00 ± 1.00 mg, 0.9mmol), and NiIICl(1-naphthyl)(PCy3)2 (11.73 ± 0.0510 mg, 0.015mmol, 5% catalyst loading). The test tube was brought into a N2 filledglove box (moisture level <2 ppm) through three degassing cycles andPCy3 (8.4 mg, 0.03 mmol, 10% loading) ligand was added. Distilled sol-vent (1 mL) was added inside the glove box and the test tube wassealed by a rubber septum and left stirring at 23 C. A sample was tak-en by syringe and transferred outside the glove box. The sample wasdiluted by distilled THF (0.2 mL) and filtered through a short columnof Al2O3. The filtrate was concentrated and the GC analysis was car-ried out. The reaction mixture was diluted with CH2Cl2 (2 mL), filteredthrough a layer of Al2O3, and washed with CH2Cl2 (3 1 mL). The fil-trate was collected and concentrated under vacuum. The crude prod-uct was purified by column chromatography on silica gel with EtO-Ac/hexane mixture as eluent. The reductive elimination side-productwas also isolated and characterized.
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