Alternatived Products of [ 527680-57-5 ]
Product Details of [ 527680-57-5 ]
CAS No. : | 527680-57-5 |
MDL No. : | N/A |
Formula : |
C20H24N2O7
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
404.41
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 527680-57-5 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 527680-57-5 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 527680-57-5 ]
- 1
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[ 4442-54-0 ]
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[ 6530-09-2 ]
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[ 527680-57-5 ]
Yield | Reaction Conditions | Operation in experiment |
634 mg (71%) |
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In acetonitrile; |
EXAMPLE 1 N-((3R)-1-azabicyclo[2.2.2]oct-3-yl)-2,3-dihydro-1,4-benzodioxine-6-carboxamide fumarate To a stirred solution of 0.59 g (3.3 mmol) of 1,4-benzodioxane-6-carboxylic acid in CH3CN (30 mL) in a -10 C. methanol-ice bath is added sequentially DIEA (1.65 mL, 9.5 mmol), 3(R)-aminoquinuclidine dihydrochloride (0.62 g, 3.11 mmol) and HATU (1.18 g, 3.11 mmol). The mixture is stirred at -10 C. for 1 h, followed by warming to rt and stirring overnight. The mixture is concentrated in vacuo to a yellow residue. The crude product is purified by flash chromatography on SiO2. Elution with CHCl3-MeOH-NH4OH (90:9:1) gave 634 mg (71%) of a light yellow solid. MS(ESI) m/e 289 [M+H]. |