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[ CAS No. 54904-02-8 ] {[proInfo.proName]}

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Chemical Structure| 54904-02-8
Chemical Structure| 54904-02-8
Structure of 54904-02-8 * Storage: {[proInfo.prStorage]}
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Product Details of [ 54904-02-8 ]

CAS No. :54904-02-8 MDL No. :
Formula : C11H9BrN2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 249.11 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 54904-02-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 54904-02-8 ]

[ 54904-02-8 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 2402-97-3 ]
  • [ 103-71-9 ]
  • [ 54904-03-9 ]
  • [ 54904-02-8 ]
  • [ 54904-01-7 ]
YieldReaction ConditionsOperation in experiment
1: 66% 2: 4% 3: 4% In N,N-dimethyl-formamide for 10h; Ambient temperature;
  • 2
  • [ 54904-02-8 ]
  • [ 244-76-8 ]
YieldReaction ConditionsOperation in experiment
90% With palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tricyclohexylphosphine tetrafluoroborate In N,N-dimethyl acetamide; o-xylene at 145℃; for 16h; Inert atmosphere;
88% With potassium <i>tert</i>-butylate; ammonia for 1h; Inert atmosphere; Irradiation;
76% With palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; CyJohnPhos In N,N-dimethyl acetamide at 140℃; for 1h; Inert atmosphere; 2 Preparation of Compound B Nitrogen (N2) under (2-biphenyl) hexyl dish kilo phosphine ((2-Biphenyl) dicyclohexylphosphine) (5.5g, 22mmol), Pd (OAc) 2 (0.15g, 0.66mmol) dissolved in DMAc into a room temperature in the mixture was stirred for 30 minutes. Compound A (5.5g, 22mmol) and Dbu (1,8- dia carbidopa bicyclo [5.4.0] undec -7-ene) (Dbu (1,8-Diazabicyclo [5,4,0] undec-7- ene)) (put dissolved in 6.7g, 44mmol) and DMAc. At 140 and refluxed for 1 hour. After the completion of the reaction solution after cooled to room temperature and filtered using a silica gel pad and the filtrate under reduced pressure to remove the volatiles. The residue via column chromatography gave Compound B 2.8g (76% yield).
70% With palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; CyJohnPhos In N,N-dimethyl acetamide for 24h; Reflux; 1.1 To a round bottom flask was added 3-bromo-N-phenylpyridin-2-amine (7.5 g, 30 mmol)(2-biphenyl) dicyclohexylphosphine (0.633 g, 1.81 mmol), palladium (II) acetate (0.13 g, 0.58 mmol)1,8-diazabicyclo [5.4.0] undec-7-ene (9.2 ml, 60 mmol)dimethylacetamide (150 ml), and the mixture was refluxed for 24 hours.After confirming by HPLC, the reaction was terminated.The solvent was evaporated and column (EA: Hex = 6: 1)To obtain a solid compound (3.5 g, yield = 70%). (EA: ethylacetate)
70% With palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; CyJohnPhos In N,N-dimethyl acetamide for 24h; Reflux; 1.2 (2) Synthesis of 9H-pyrido [2,3-b] indole To a round bottom flask was added 3-bromo-N-phenylpyridin-2-amine (7.5 g, 30 mmol) (2-biphenyl)dicyclohexylphosphine (0.633 g, 1.81 mmol), palladium(II) acetate (0.13 g, 0.58 mmol), 1,8-diazabicyclo[5.4.0]undec-7-ene (9.2 mL, 60 mmol) And dissolved in 150 mL of dimethylacetamide. After refluxing for 24 hours; After confirming by HPLC, the reaction was terminated, After evaporation of the solvent, column (EA: HEX = 6: 1) 9H-pyrido[2,3-b]indole 3.5 g (Yield: 70%).
31% With sodium carbonate In N,N-dimethyl-formamide for 67h; Heating;
18.4% With sodium carbonate In N,N-dimethyl-formamide at 165℃; for 67h;
With C26H35P; palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl acetamide

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