Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 54904-02-8 | MDL No. : | |
Formula : | C11H9BrN2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 249.11 | Pubchem ID : | - |
Synonyms : |
|
Signal Word: | Class: | ||
Precautionary Statements: | UN#: | ||
Hazard Statements: | Packing Group: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1: 66% 2: 4% 3: 4% | In N,N-dimethyl-formamide for 10h; Ambient temperature; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | With palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tricyclohexylphosphine tetrafluoroborate In N,N-dimethyl acetamide; o-xylene at 145℃; for 16h; Inert atmosphere; | |
88% | With potassium <i>tert</i>-butylate; ammonia for 1h; Inert atmosphere; Irradiation; | |
76% | With palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; CyJohnPhos In N,N-dimethyl acetamide at 140℃; for 1h; Inert atmosphere; | 2 Preparation of Compound B Nitrogen (N2) under (2-biphenyl) hexyl dish kilo phosphine ((2-Biphenyl) dicyclohexylphosphine) (5.5g, 22mmol), Pd (OAc) 2 (0.15g, 0.66mmol) dissolved in DMAc into a room temperature in the mixture was stirred for 30 minutes. Compound A (5.5g, 22mmol) and Dbu (1,8- dia carbidopa bicyclo [5.4.0] undec -7-ene) (Dbu (1,8-Diazabicyclo [5,4,0] undec-7- ene)) (put dissolved in 6.7g, 44mmol) and DMAc. At 140 and refluxed for 1 hour. After the completion of the reaction solution after cooled to room temperature and filtered using a silica gel pad and the filtrate under reduced pressure to remove the volatiles. The residue via column chromatography gave Compound B 2.8g (76% yield). |
70% | With palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; CyJohnPhos In N,N-dimethyl acetamide for 24h; Reflux; | 1.1 To a round bottom flask was added 3-bromo-N-phenylpyridin-2-amine (7.5 g, 30 mmol)(2-biphenyl) dicyclohexylphosphine (0.633 g, 1.81 mmol), palladium (II) acetate (0.13 g, 0.58 mmol)1,8-diazabicyclo [5.4.0] undec-7-ene (9.2 ml, 60 mmol)dimethylacetamide (150 ml), and the mixture was refluxed for 24 hours.After confirming by HPLC, the reaction was terminated.The solvent was evaporated and column (EA: Hex = 6: 1)To obtain a solid compound (3.5 g, yield = 70%). (EA: ethylacetate) |
70% | With palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; CyJohnPhos In N,N-dimethyl acetamide for 24h; Reflux; | 1.2 (2) Synthesis of 9H-pyrido [2,3-b] indole To a round bottom flask was added 3-bromo-N-phenylpyridin-2-amine (7.5 g, 30 mmol) (2-biphenyl)dicyclohexylphosphine (0.633 g, 1.81 mmol), palladium(II) acetate (0.13 g, 0.58 mmol), 1,8-diazabicyclo[5.4.0]undec-7-ene (9.2 mL, 60 mmol) And dissolved in 150 mL of dimethylacetamide. After refluxing for 24 hours; After confirming by HPLC, the reaction was terminated, After evaporation of the solvent, column (EA: HEX = 6: 1) 9H-pyrido[2,3-b]indole 3.5 g (Yield: 70%). |
31% | With sodium carbonate In N,N-dimethyl-formamide for 67h; Heating; | |
18.4% | With sodium carbonate In N,N-dimethyl-formamide at 165℃; for 67h; | |
With C26H35P; palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl acetamide |