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[ CAS No. 59119-18-5 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 59119-18-5
Chemical Structure| 59119-18-5
Structure of 59119-18-5 * Storage: {[proInfo.prStorage]}
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Product Details of [ 59119-18-5 ]

CAS No. :59119-18-5 MDL No. :MFCD06208305
Formula : C13H17NO3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 235.28 Pubchem ID :-
Synonyms :

Safety of [ 59119-18-5 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 59119-18-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 59119-18-5 ]
  • Downstream synthetic route of [ 59119-18-5 ]

[ 59119-18-5 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 67-56-1 ]
  • [ 59119-18-5 ]
  • [ 60437-30-1 ]
YieldReaction ConditionsOperation in experiment
11.2 g for 12 h; Reflux A solution of sodium metabisulfate (14.5 g, 0.075 mol) in distilled water (60 mL) was added over 2h to a stirred mixture of 1 (23.2 g, 123 mmol), potassium cyanide (9.9 g, 153 mmol), and water (60 mL). The mixture was stirred at 25° C. for 5 hours. The mixture was extracted with ethyl acetate (2×100 mL) and the organics dried (MgSO4), and concentrated to give an oil which slowly solidified on standing at RT. The waxy solid was triturated with hexanes-ether (9:1) and filtered to give 14.9 g of the corresponding cyanohydrin. This solid was dissolved in acetic acid (25 mL) and the solution was diluted with concentrated HCl (75 mL). The solution was refluxed for 3 hours and concentrated to a solid mass. Toluene (100 mL) was added to the solid mass and the mixture was evaporated. This process was repeated one additional time. The resulting solid was then diluted with MeOH (100 mL) and treated with concentrated sulfuric acid (3.4 g). The solution was refluxed for 12 hours and concentrated to an oily residue which was diluted with a saturated solution of sodium bicarbonate (100 mL) and then extracted with EtOAc (2×100 mL). The organics were dried (MgSO4), filtered, concentrated, and chromatographed on silica gel (60percent hexanes/40percent EtOAc) to give 2 (11.2 g) as an amber oil.
Reference: [1] Patent: US9156825, 2015, B2, . Location in patent: Page/Page column 67
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