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Inhibitors/Agonists
Endoplasmic reticulum stress
Antioxidant
5,7-Dimethoxy-4-methylcoumarin
Inhibitors/Agonists
Endoplasmic reticulum stress
Antioxidant

[ CAS No. 6093-80-7 ] {[proInfo.proName]}

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Chemical Structure| 6093-80-7
Chemical Structure| 6093-80-7
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Product Details of [ 6093-80-7 ]

CAS No. :6093-80-7 MDL No. :MFCD00510072
Formula : C12H12O4 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 220.22 Pubchem ID :-
Synonyms :
Chemical Name :5,7-Dimethoxy-4-methyl-2H-chromen-2-one

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Application In Synthesis of [ 6093-80-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6093-80-7 ]

[ 6093-80-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 2107-76-8 ]
  • [ 74-88-4 ]
  • [ 6093-80-7 ]
YieldReaction ConditionsOperation in experiment
87.5% With potassium carbonate In acetone for 2h; Reflux; 2.3. 5,7-Dimethoxy-4-methyl-chromen-2-one (10) Methyl iodide (0.54 mL, 8.7 mmol) was added to a mixture of 9(0.5 g, 2.9 mmol) and potassium carbonate (0.8 g, 5.8 mmol) in anhydrousacetone (20 mL). Then reflux the mixture for 2 h. The mixturewas cooled at room temperature and added dist. water, and filtration,washed with water. The crude product was crystallized with MeOH togive the product 10.1H NMR (500 MHz, CD3OD) δ 2.56 (d, J=1.0 Hz,3H), 3.88 (s, 3H), 3.90 (s, 3H), 5.96 (d, J=1.0 Hz, 1H), 6.26 (d,J=2.0 Hz, 1H), 6.51 (d, J=2.0 Hz, 1H).
With potassium carbonate; acetone
Reference： [1]Lin, Mei-Hsiang; Wang, Juo-Shan; Hsieh, Yi-Chen; Zheng, Jia-Huei; Cho, Er-Chieh [Chemico-Biological Interactions, 2019, vol. 309]
[2]Canter et al. [Journal of the Chemical Society, 1931, p. 1255,1264]
  • 2
  • [ 275818-95-6 ]
  • [ 6093-80-7 ]
  • 3-difluoromethyl-5,7-dimethoxy-4-methyl-2H-chromen-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
79% With dipotassium peroxodisulfate; In dimethyl sulfoxide; at 90℃; for 12h; General procedure: To a 10 mL Schlenk tube, coumarin 1a (0.3 mmol, 1 equiv),difluoromethane-sulfinate (0.6 mmol, 2 equiv), K2S2O8 (3 equiv.)were dissolved in DMSO (2.0 mL). Then the mixture was stirred at90 C for 12 h. To the residue was added water (10 mL) andextracted with ethyl acetate (5 mL 3). The combined organicfractions were dried over Na2SO4, and concentrated under vacuumto yield the crude product, which was purified by column chromatographyto give the target product. The same procedure was applied for to produce other compounds, after purification by silicagel column chromatography (EA: PE 1/10 to 1/2).
Reference： [1]Tetrahedron,2021,vol. 100
[2]Organic Letters,2018,vol. 20,p. 6901 - 6905
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Endoplasmic reticulum stress
Antioxidant
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