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Chemistry
Asymmetric Synthesis
Piperazines
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(S)-2-(4-Fluorophenyl)piperazine
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[ CAS No. 612507-29-6 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 612507-29-6
Chemical Structure| 612507-29-6
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Alternatived Products of [ 612507-29-6 ]

Product Details of [ 612507-29-6 ]

CAS No. :612507-29-6 MDL No. :
Formula : C10H13FN2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 180.22 Pubchem ID :-
Synonyms :

Safety of [ 612507-29-6 ]

Signal Word: Class:
Precautionary Statements: UN#:
Hazard Statements: Packing Group:

Application In Synthesis of [ 612507-29-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 612507-29-6 ]

[ 612507-29-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 612507-29-6 ]
  • [ 69034-12-4 ]
  • C15H14F4N4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
64% With N-ethyl-N,N-diisopropylamine; at 100℃; for 2h;Microwave irradiation; Example 69a Single Enantiomer; S Configuration N,N-Diisopropylethylamine (30 mul, 0.2 mmol) is added to a stirred solution of example 68a (30 mg, 0.2 mmol) and 2-Chloro-5-(Trifluoromethyl)pyrimidine (30 mg, 0.2 mmol) and the reaction mixture is heated in a microwave reactor 2 hours at 100 C. The crude is partitioned between water and EtOAc then the organic layer is separated, washed with water, dried over anhydrous Na2SO4 and concentrated under reduced pressure; the residue is purified by Silica gel flash chromatography, using DCM/MeOH 100:2 as eluent, to obtain the title compound (35 mg, 64% yield). [0429] UPLC-MS (method 1): Rt=0.89 min [0430] MS (ES+): m/z=327 [M+H]+
64% With N-ethyl-N,N-diisopropylamine; at 100℃; for 2h;Microwave irradiation; N,N-Diisopropylethylamine (30 mu, 0.2 mmol) is added to a stirred solution of example 68a (30 mg, 0.2 mmol) and 2-Chloro-5-(Trifluoromethyl)pyrimidine (30 mg, 0.2 mmol) and the reaction mixture is heated in a microwave reactor 2 hours at 100C. The crude is partitioned between water and EtOAc then the organic layer is separated, washed with water, dried over anhydrous Na2S04 and concentrated under reduced pressure; the residue is purified by Silica gel flash chromatography, using DCM/MeOH 100:2 as eluent, to obtain the title compound (35 mg, 64% yield). UPLC-MS (method 1): Rt = 0.89 MS (ES+): m/z = 327 [M+H]+ .
Reference： [1]Patent: US2015/105397,2015,A1 .Location in patent: Paragraph 0427; 0428; 0429; 0430
[2]Patent: WO2015/55698,2015,A1 .Location in patent: Page/Page column 90

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