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[ CAS No. 61315-61-5 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 61315-61-5
Chemical Structure| 61315-61-5
Structure of 61315-61-5 * Storage: {[proInfo.prStorage]}
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Product Details of [ 61315-61-5 ]

CAS No. :61315-61-5 MDL No. :MFCD00038260
Formula : C18H28N4O6S Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 428.50 Pubchem ID :-
Synonyms :

Safety of [ 61315-61-5 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P280-P305+P351+P338 UN#:N/A
Hazard Statements:H317-H319 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 61315-61-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 61315-61-5 ]

[ 61315-61-5 ] Synthesis Path-Downstream   1~24

  • 1
  • [ 4530-20-5 ]
  • [ 15761-39-4 ]
  • [ 5068-28-0 ]
  • [ 61315-61-5 ]
  • Boc-Asn-ONp, Boc-Gln-ONp, Boc-Phe, Boc-Tyr(Me) [ No CAS ]
  • [ 124511-30-4 ]
  • 2
  • [ 4530-20-5 ]
  • [ 15761-39-4 ]
  • [ 5068-28-0 ]
  • [ 61315-61-5 ]
  • Boc-Asn-ONp, Boc-Val, Boc-Phe, Boc-Tyr(Me) [ No CAS ]
  • [ 124511-32-6 ]
  • 3
  • [ 4530-20-5 ]
  • [ 15761-39-4 ]
  • [ 5068-28-0 ]
  • [ 61315-61-5 ]
  • Boc-Asn-ONp, Boc-Val, Boc-Phe, Boc-Tyr(Et) [ No CAS ]
  • [ 124511-33-7 ]
  • 4
  • [ 4530-20-5 ]
  • [ 15761-39-4 ]
  • [ 5068-28-0 ]
  • [ 61315-61-5 ]
  • Boc-Asn-ONp, Boc-Gln-ONp, Boc-Phe, Boc-Tyr(Et) [ No CAS ]
  • [ 124511-31-5 ]
  • 5
  • [ 13734-34-4 ]
  • [ 61315-61-5 ]
  • [ 125218-32-8 ]
  • [ 138228-34-9 ]
YieldReaction ConditionsOperation in experiment
Multistep reaction;
  • 6
  • [ 47689-67-8 ]
  • [ 61315-61-5 ]
  • [ 114873-01-7 ]
  • Boc-βAla-benzhydrylamine resin [ No CAS ]
  • [ 138228-28-1 ]
  • 7
  • [ 47689-67-8 ]
  • [ 61315-61-5 ]
  • [ 114873-00-6 ]
  • Boc-βAla-benzhydrylamine resin [ No CAS ]
  • [ 138228-26-9 ]
  • 8
  • [ 13734-41-3 ]
  • [ 2899-66-3 ]
  • [ 13734-34-4 ]
  • [ 61315-61-5 ]
  • Boc-Pro, Boc-Cys(Bzl), Boc-Asn NPE, Boc-Tyr(Bzl) [ No CAS ]
  • [ 110551-27-4 ]
  • 9
  • [ 13734-41-3 ]
  • [ 2899-66-3 ]
  • [ 13734-34-4 ]
  • [ 61315-61-5 ]
  • Boc-Pro, Boc-Cys(Bzl), Boc-Asn NPE, Boc-Tyr(Bzl) [ No CAS ]
  • [ 110551-16-1 ]
  • 10
  • [ 15387-45-8 ]
  • [ 2899-66-3 ]
  • [ 13734-34-4 ]
  • [ 61315-61-5 ]
  • Boc-Pro, Boc-Cys(Bzl), Boc-Asn NPE, Boc-Tyr(Bzl) [ No CAS ]
  • [ 110551-15-0 ]
  • 11
  • [ 15387-45-8 ]
  • [ 2899-66-3 ]
  • [ 13734-34-4 ]
  • [ 61315-61-5 ]
  • Boc-Pro, Boc-Cys(Bzl), Boc-Asn NPE, Boc-Tyr(Bzl) [ No CAS ]
  • [ 110567-66-3 ]
  • 12
  • [ 13836-37-8 ]
  • [ 61315-61-5 ]
  • [ 109523-13-9 ]
  • [ 180386-39-4 ]
  • Boc-Ser, Boc-D-Tic, Boc-Arg(Tos)-PAM-resin [ No CAS ]
  • C55H88N18O10 [ No CAS ]
  • 13
  • [ 13836-37-8 ]
  • [ 61315-61-5 ]
  • [ 109523-13-9 ]
  • [ 180386-37-2 ]
  • Boc-Ser, Boc-D-Tic, Boc-Arg(Tos)-PAM-resin [ No CAS ]
  • C56H90N18O10 [ No CAS ]
  • 14
  • [ 13836-37-8 ]
  • [ 61315-61-5 ]
  • [ 109523-13-9 ]
  • [ 180386-40-7 ]
  • Boc-Ser, Boc-D-Tic, Boc-Arg(Tos)-PAM-resin [ No CAS ]
  • C57H86N18O10 [ No CAS ]
  • 15
  • [ 13836-37-8 ]
  • [ 61315-61-5 ]
  • [ 109523-13-9 ]
  • [ 180386-38-3 ]
  • Boc-Ser, Boc-D-Tic, Boc-Arg(Tos)-PAM-resin [ No CAS ]
  • C52H84N18O10 [ No CAS ]
  • 16
  • [ 4530-20-5 ]
  • [ 61348-28-5 ]
  • [ 61315-61-5 ]
  • Boc-Tyr(2,6-di-Cl-Bzl)OH [ No CAS ]
  • 3-[(2R,5S,8R)-8-(3-Guanidino-propyl)-5-(4-hydroxy-benzyl)-3,6,9,12-tetraoxo-1,4,7,10-tetraaza-cyclododec-2-yl]-propionamide [ No CAS ]
  • 17
  • [ 4530-20-5 ]
  • 4-methylbenzylhydrylamine resin [ No CAS ]
  • Boc-2Nal [ No CAS ]
  • [ 214630-10-1 ]
  • [ 35661-40-6 ]
  • [ 54613-99-9 ]
  • [ 47689-67-8 ]
  • [ 61315-61-5 ]
  • C129H130BrCl2N14O19PolS [ No CAS ]
YieldReaction ConditionsOperation in experiment
86 The sequence Fmoc-Phe-Tyr(2-Br-Z)-Lys(2-Cl-Z)-DArg(Tos)-2Nal-Gly-DGlu(OFm)-Lys(2-Cl-Z) (SEQ ID NO: 102) is manually assembled on MBHA (4-methyl-benzhydryl-amine) resin (Cat. No. D-2095, BaChem California Inc., Torrance, Calif.) using established solid phase peptide synthesis Boc chemistry (Schnolzer et al. (1992) Int. J. Pept. Protein Res. 40:180-193) as outlined in Scheme 10. The chain assembly is carried out using an in situ neutralization/HBTU/DIEA activation procedure as described in this reference. The side chain protecting group scheme is: Lys(2-Cl-Z), DGlu(OFm), DArg(Tos), and Tyr(2-Br-Z). The alpha-amino group of all the amino acid building blocks is protected with tert-butoxycarbonyl (Boc) except the N-terminal residue Phe, which is protected with Fmoc for efficiency of synthesis. The stepwise chain assembly starts from the C-terminal end of the linear peptide and is accomplished in 8 steps. In step 1, five equivalents of protected amino acid Boc-Lys(2-Cl-Z) are activated with HBTU/DIEA in DMF, and coupled to MBHA resin. In step 2, five equivalents of Boc-DGlu(OFm) are activated and coupled to the deprotected peptide resin from step 1 using neat TFA. These steps are repeated appropriately until step 8, the coupling of Fmoc-Phe.
  • 18
  • [ 4530-20-5 ]
  • 4-methylbenzylhydrylamine resin [ No CAS ]
  • Boc-2Nal [ No CAS ]
  • [ 13734-34-4 ]
  • [ 84624-27-1 ]
  • [ 47689-67-8 ]
  • [ 34404-30-3 ]
  • [ 61315-61-5 ]
  • C126H134BrN14O19PolS [ No CAS ]
YieldReaction ConditionsOperation in experiment
The sequence Boc-Phe-Tyr(2-Br-Z)-Lys(Fmoc)-DArg(Tos)-2Nal-Gly-DGlu(OBzl)-Lys(Fmoc) (SEQ ID NO:103) is manually assembled on MBHA resin using solid phase peptide synthesis Boc chemistry (Schnolzer et al. (1992) Int. J. Pept. Protein Res. 40:180-193) as outlined in Scheme 11. The chain assembly is carried out using the in situ neutralization/HBTU/DIEA activation procedure as described in Schnolzer et al. The side chain protecting group scheme is: Lys(Fmoc), DGlu(OBZl), DArg(Tos), Tyr(2-Br-Z). The alpha-amino group of all the amino acid building blocks is protected with tert-butoxycarbonyl (Boc). The stepwise chain assembly starts from the C-terminal end of the linear peptide and is accomplished in 8 steps as shown in Scheme 11. In step 1, five equivalents of protected amino acid Boc-Lys(2-Cl-Z) are activated with HBTU (4 eq)/DIEA (10 eq) in DMF, and coupled to MBHA resin. In step 2, five equivalents of Boc-DGlu(OBzl) are activated and coupled to the deprotected peptide resin from step 1 using neat TFA. These steps are repeated appropriately until step 8, the coupling of Boc-Phe. The Boc protecting group is removed with neat TFA, the resin is neutralized with DIEA, and washed with DMF and methanol and dried in air before HF cleavage. The linear peptide is simultaneously deprotected and cleaved from the resin using HF with 5% m-cresol or p-cresol as a scavenger for 1 hour at 0 C. The solvents are then evaporated and the crude peptide is precipitated and washed three times with cold diethyl ether.
  • 19
  • Boc-D-Asp(OcHex)-OH [ No CAS ]
  • [ 4530-20-5 ]
  • [ 3744-87-4 ]
  • C7H12NO3PolS [ No CAS ]
  • [ 16937-99-8 ]
  • [ 18942-49-9 ]
  • [ 61925-78-8 ]
  • [ 5241-66-7 ]
  • [ 61315-61-5 ]
  • [ 37784-17-1 ]
  • [ 57096-11-4 ]
  • all-D-(Thz-Leu-Lys-Pro-Cys-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-CO-S-CH2-CH2-CO-Ala-COOH) [ No CAS ]
  • 20
  • [ 200192-48-9 ]
  • C7H15N2O2Pol [ No CAS ]
  • [ 61925-78-8 ]
  • [ 5241-66-7 ]
  • [ 61315-61-5 ]
  • [ 108787-48-0 ]
  • [ 37784-17-1 ]
  • [ 57096-11-4 ]
  • [ 63091-82-7 ]
  • [ 69355-99-3 ]
  • all-D-(Thz-Met-Asn-Arg-Lys-Cys-His-Cys-Thr-Pro-Lys-COOH) [ No CAS ]
  • 21
  • Boc-D-Asp(OcHex)-OH [ No CAS ]
  • [ 4530-20-5 ]
  • C16H29NO6 [ No CAS ]
  • C26H26NO3PolS [ No CAS ]
  • [ 16937-99-8 ]
  • [ 47173-80-8 ]
  • [ 81189-61-9 ]
  • [ 61925-78-8 ]
  • [ 61315-61-5 ]
  • [ 37784-17-1 ]
  • [ 57096-11-4 ]
  • [ 63091-82-7 ]
  • D-proinsulin[(D-Thz19)-(D-Cys71)]-α-COSCH2CH2CO-(D-Ala)-COOH [ No CAS ]
  • 22
  • [ 15761-39-4 ]
  • [ 13734-34-4 ]
  • [ 1212411-75-0 ]
  • C21H25N2O3Pol [ No CAS ]
  • [ 18942-46-6 ]
  • [ 132388-68-2 ]
  • [ 132388-69-3 ]
  • [ 61315-61-5 ]
  • C50H73N15O11S2 [ No CAS ]
  • 23
  • Boc-D-Asp(OcHex)-OH [ No CAS ]
  • [ 4530-20-5 ]
  • [ 200192-48-9 ]
  • [ 3744-87-4 ]
  • [ 16937-99-8 ]
  • [ 47173-80-8 ]
  • [ 18942-49-9 ]
  • [ 81189-61-9 ]
  • [ 61925-78-8 ]
  • [ 61315-61-5 ]
  • [ 55721-65-8 ]
  • [ 57096-11-4 ]
  • mercaptopropionyl-Gly-O-CH2-phi-CH2CO-aminomethyl polystyrene resin [ No CAS ]
  • C134H223N41O41S7 [ No CAS ]
  • 24
  • Boc-D-Asp(OcHex)-OH [ No CAS ]
  • [ 4530-20-5 ]
  • [ 200192-48-9 ]
  • [ 22838-58-0 ]
  • [ 47173-80-8 ]
  • [ 81189-61-9 ]
  • [ 61925-78-8 ]
  • [ 61315-61-5 ]
  • [ 103343-26-6 ]
  • [ 37784-17-1 ]
  • [ 57096-11-4 ]
  • [ 69355-99-3 ]
  • (R)-2-(tert-butoxycarbonylamino)-5-(cyclohexyloxy)-5-oxopentanoic acid [ No CAS ]
  • D-[ceeckcvpsgtygnkhecpcyrdkknskgkskcp] [ No CAS ]
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