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[ CAS No. 61478-25-9 ] {[proInfo.proName]}

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Chemical Structure| 61478-25-9
Chemical Structure| 61478-25-9
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CAS No. :61478-25-9 MDL No. :MFCD11977336
Formula : C7H13NO3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 159.18 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 61478-25-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 61478-25-9 ]
  • Downstream synthetic route of [ 61478-25-9 ]

[ 61478-25-9 ] Synthesis Path-Upstream   1~3

  • 1
  • [ 24424-99-5 ]
  • [ 61478-25-9 ]
  • [ 37813-30-2 ]
YieldReaction ConditionsOperation in experiment
74.9% With triethylamine In ethanol; dichloromethane at 0 - 20℃; Example 214. Synthesis of 3-fluoro-2-(4-(3-((2S,4R)-4-hydroxy-2- (hydroxymethyl)pyro-lidin-l-yl)-lH-pyrazol-l-yl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4- b]pyridin-2-yl)benzonitrile, 1-214 Synthesis of compound 214.2. To a solution of 214.1 (5.0 g, 25.6mmol, l.Oeq) in DCM (50 niL) and ethanol (10 niL) was added Et3N (5.2 niL, 0.038 mmol, 1.5 eq) di-tert.butyl dicarbonate (032mmol, 1.2eq) at 0 °C. Reaction mixture was stirred at room temperature for 16 h. Upon completion of the reaction, mixture was transferred into water and extracted with DCM, combined organic layers were washed with brine, dried over Na2S04 and concentrated under reduced pressure to obtained crude which was purified by column chromatography to furnish 214.2 . (6.1 g, 74.9 percent). MS(ES): m/z 260.12 [M+H]+.
Reference: [1] Patent: WO2017/40757, 2017, A1, . Location in patent: Paragraph 00954-00955
[2] Tetrahedron Asymmetry, 2002, vol. 13, # 2, p. 167 - 172
[3] Angewandte Chemie - International Edition, 2009, vol. 48, # 10, p. 1784 - 1787
  • 2
  • [ 41840-28-2 ]
  • [ 61478-25-9 ]
  • [ 37813-30-2 ]
Reference: [1] Journal of Organic Chemistry, 1980, vol. 45, # 23, p. 4728 - 4739
  • 3
  • [ 61478-25-9 ]
  • [ 61478-26-0 ]
Reference: [1] Journal of Organic Chemistry, 1980, vol. 45, # 23, p. 4728 - 4739
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