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CAS No. : | 624-49-7 | MDL No. : | MFCD00064438 |
Formula : | C6H8O4 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | LDCRTTXIJACKKU-ONEGZZNKSA-N |
M.W : | 144.13 | Pubchem ID : | 637568 |
Synonyms : |
NSC 25942;trans-Butenedioic Acid dimethyl ester;DMF;NSC 167432
|
Num. heavy atoms : | 10 |
Num. arom. heavy atoms : | 0 |
Fraction Csp3 : | 0.33 |
Num. rotatable bonds : | 4 |
Num. H-bond acceptors : | 4.0 |
Num. H-bond donors : | 0.0 |
Molar Refractivity : | 33.05 |
TPSA : | 52.6 Ų |
GI absorption : | High |
BBB permeant : | No |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -7.02 cm/s |
Log Po/w (iLOGP) : | 1.93 |
Log Po/w (XLOGP3) : | 0.22 |
Log Po/w (WLOGP) : | -0.11 |
Log Po/w (MLOGP) : | 0.15 |
Log Po/w (SILICOS-IT) : | 0.2 |
Consensus Log Po/w : | 0.48 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -0.61 |
Solubility : | 35.5 mg/ml ; 0.247 mol/l |
Class : | Very soluble |
Log S (Ali) : | -0.88 |
Solubility : | 18.8 mg/ml ; 0.131 mol/l |
Class : | Very soluble |
Log S (SILICOS-IT) : | -0.1 |
Solubility : | 115.0 mg/ml ; 0.796 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 2.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 2.12 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P260-P264-P270-P271-P272-P273-P280-P301+P312+P330-P302+P352-P304+P340+P312-P305+P351+P338-P312-P333+P313-P337+P313-P403+P233-P405-P501 | UN#: | N/A |
Hazard Statements: | H302-H313-H317-H319-H335-H373-H401 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
78% | In 5,5-dimethyl-1,3-cyclohexadiene; at 130℃; for 24h; | A mixture of anthracene (2.00g, 11.2mmol), dimethyl fumarate (2.05g, 14.2mmol) and xylene (15mL) in a pressured tube with boiling chips was heated at 130C for 24h. The reaction mixture was cooled to rt and the xylene was then removed under vacuo. The crude product was purified using column chromatography (silica gel, 30:1 hexane/EtOAc) to afford the adduct 3 (2.82g, 78%) as a white solid, mp 103-105C (lit.11 107-108C); IR (CH2Cl2) numax: 1732, 1459, 1435, 1221, 1198, 1018, 760cm-1; 1H NMR delta 7.28-7.31 (m, 2H), 7.22-7.25 (m, 2H), 7.07-7.14 (m, 4H), 4.73 (s, 2H), 3.62 (s, 6H), 3.42 (s, 2H); 13C NMR delta 172.8, 142.0, 140.3, 126.4, 126.3, 124.6, 123.8, 52.2, 47.8, 46.7. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | In acetonitrile; at 0 - 20℃; for 16h; | (A-1) dimethyl fumarate (30g,0.21mol) was dissolved in acetonitrile (200ml) under heating and isopropylamine (25g, 0.42mol) was added thereto under ice cooling,then the mixuture was stirred for 16 hours at room temperature.. Evaporation of the solvent and the excess isopropylamine under reduced pressure gave dimethyl 2-isopropylaminosuccinate (42g, yield: 100%). NMR(CDCl3)delta: 1.01(3H, d, J=6.0Hz), 1.05(3H, d, J=6.3Hz), 2.67(1H, t, J=9.9Hz), 2.79(1H, m), 3.69(3H, s), 3.74(3H, s), 3.68-3.75(2H, m). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride; n-butyllithium; trichloroacetic acid; In tetrahydrofuran; water; toluene; | (a) Dimethyl 9-(4-Fluorophenyl)-6-methylnaphtho[1,2-d]-1,3-dioxole-7,8-dicarboxylate STR90 To a THF (200 ml) solution of 1-(1,3-benzodioxol-5-yl)-ethanol (8.2 g) was dropwise added butyl lithium 1.6M (hexane solution, 68.7 ml) at 0 C. The mixture was stirred for 1.5 hours and THF (30 ml) solution of p-fluorobenzonitrile (6.9 g) was dropwise added thereto and stirred for 1 hour at 0 C. To the reaction mixture was added water and the mixture was extracted with diethyl ether and dried with magnesium sulfate, then the solvent was distilled off under reduced pressure. The obtained residue was dissolved in toluene (200 ml), then dimethyl fumarate (14.4 g) and trichloroacetic acid (2.45 g) were added therein, and heated under reflux for 3 hours. After cooling, the solvent was distilled off under reduced pressure, and concentrated hydrochloric acid (75 ml) was added thereto. The reaction mixture was heated under reflux for 1 hour, separated crystals were collected and washed with, methanol and ether to give the entitled compound (2.0 g). m.p.:160-162 C. (AcOEt-isopropyl ether); NMR(CDCl3)delta: 2.74(3H,s), 3.50(3H,s), 3.90(3H,s), 5.82(2H,s), 6.92-7.33(5H,m), 7.76(1H,d,J=9 Hz) Elemental Analysis for C22 H17 FO6 Calcd.: C:66.67%, H:3.95%, N:4.79%; Found: C:66.63%, H:4.25%, N:4.53%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
85% | With hydrogenchloride; NaOCH3; In acetone; | EXAMPLE II Preparation of Trimethyl Acetotricarballylate 14.4 grams (0.1 mole) of dimethyl fumarate are placed into 15.5 grams (0.13 mole) of methyl acetoacetate in a 100 ml flask equipped with stirrer and drying tube. One gram (0.018 mole) NaOCH3 is added and the mixture is heated to 50-55 C. for one hour. 1.8 g conc. hydrochloric acid is added dropwise followed by 100 ml of acetone. The solution is filtered and evaporated under vacuum to remove unreacted fumarate and acetoacetate esters. 22 grams (85% yield) of product is obtained having an NMR identical to that of Example I. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
79.7% | (4) A mixture of 4.00g of the compound obtained in the above (3), 1.59g of dimethyl fumarate, 20mL of xylene and 2g of acetic acid was refluxed under heating for 2 hours. After radiation, the reaction solution was concentrated under reduced pressure. To the residue was added 8mL of toluene, and the solution was concentrated. To the resulting residue was added 8mL of acetonitrile, and then added dropwise 3.55g of boron trifluoride-diethylether in an ice-water bath. The mixture was refluxed under heating for 2 hours. After radiation the reaction solution was concentrated under reduced pressure. To the residue was added 28mL of chloroform, which was ice-cooled. To the mixture was added dropwise 3.41g of 25% aqueous ammonia at 25C or below, and then the mixture was stirred at 45 to 50C for 15 minutes. To the reaction solution was added 24mL of water, and then the organic layer was washed with 20mL of water and 28g of 20% saline, dried over magnesium sulfate, and then concentrated under reduced pressure. To the resulting residue was added 12mL of methanol and the mixture was heated. The solution was cooled, and the precipitated crystals were collected by filtration to give 3.67g of 1-(2-bromo-4-pyridyl)-2,3-bis(methoxycarbonyl)-6,7-dimethoxynaphthalene (yield: 79.7%) as crystals. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | To a solution of intermediate compound 17 (5.91g, 0. [0294MOL)] and pyridine (catalytic amount) in [100ML] [OF CHC13, N-CHLOROSUCCINIMIDE] (4.32g, 0. [032MOL)] was added portionwise at room temperature. the reaction was heated to reflux temperature for [30MIN.] After cooling to [0C,] dimethyl [INARATE] (4.24g, 0. [0294MOL)] and triethylamine (4. [91ML,] 0. [035MOL)] were added. The reaction was stirred for 48h at room temperature. Then a saturated aqueous solution of [NACO3] was added and the organic layer was separated, dried [(NA2S04),] filtered and the solvent was evaporated. The residue was purified by short open column chromatography over silica gel (eluent : [DCM/ETHYL] acetate 95/5). The desired fractions were collected and the solvent evaporated. Yielding: 9.14g (90%) of 3-(2-bromo-pyridin-3-yl)-4, 5-dihydro-isoxazole- 4,5-dicarboxylic acid dimethyl ester (intermediate compound 18). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
56% | A mixture of t-BuOH (1.30 mL) and THF (20 mL) was cooled to 0 C and treated first dropwise with BuLi (5.55 mL, 13.88 mmol), and after 15 min with 11 (1.00 g, 6.94 mmol). Stirring was continued for 1 h at 0 C and then at r.t. for 1 h. The reaction was quenched with NH4Cl and the mixture was extracted with EtOAc (3 × 50 mL). The organic phases were washed with brine, dried over MgSO4 and purified by column chromatography (silica gel 60; hexanes/EtOAc, 19:1) to give 12. Yield: 886 mg (3.88 mmol); white solid; mp 69 C [Lit.26 69 C]; Rf =0.88 (hexanes/EtOAc, 8:1). IR (ATR): 2982, 2940, 1703, 1368, 1138, 974, 846, 777, 767, 673 cm-1. 1H NMR (300 MHz, CDCl3): delta = 1.50 (s, 18 H, CH3), 6.67 (s, 2 H, CH). 13C NMR (75.5 Hz, CDCl3): delta = 28.1 (CH3), 81.6 (C(CH3)3), 134.7 (CH), 164.7 (CO). HRMS: m/z [M + Na]+ calcd for C12H20O4Na: 251.12521; found: 251.12538. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
98% | With hydroquinone; at 150℃; for 2h;Microwave irradiation; | A 35 mL MW vial was charged with dicyclopentadiene (2.0 mL, 15.0 mmol), dimethyl fumarate(2.88 g, 20.0 mmol) and hydroquinone (100 mg, 0.90 mmol), and heated using microwave irradiationto 150 C for 2 h. The resulting orange oil was purified by flash column chromatography (10% EtOAcin pet. spirits) to give a clear oil (4.14 g, 98%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With N-((S)-3,3-dimethyl-1-oxo-1-(((S)-1-phenylethyl)amino)butan-2-yl)-2-(diphenylphosphino)benzamide; silver carbonate; In toluene; at 20℃; for 2h;Inert atmosphere; | General procedure: Ligand of 1g (3.132 mg, 0.006 mmol) and Ag2CO3 (0.83 mg, 0.003 mmol,) were dissolved in toluene(1.4 ml). The reaction mixture was stirred for 1h at room temperature, followed by the addition of the activated olefins (0.33 mmol), Et3N (0.015 mmol) and imine substrate (0.3 mmol). Once starting material was consumed (monitored by TLC), the mixture purified by column chromatography to give the corresponding cycloaddition product, which was then directly analyzed by chiral HPLC | |
With 2-(diphenylphosphino)-N-((S)-2-(((1S,2S)-2-(isobutylamino)-1,2-diphenylethyl)amino)-2-oxo-1-phenylethyl)benzamide; silver carbonate; In toluene; at 20℃;Inert atmosphere; | General procedure: Precat. 1g (5.51 mg, 0.008 mmol) and Ag2CO3 (1.09 mg, 0.004 mmol), were dissolved in toluene (1.4 ml). The reaction mixture was stirred for 1h at room temperature, followed by the addition of the diethyl maleate 2a (34.4 mg, 0.2 mmol), and imine substrate 3 (0.24 mmol). Once starting material was consumed (monitored by TLC), the mixture was purified by column chromatography to give the corresponding cycloaddition product, which was then directly analyzed by chiral HPLC. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
77% | With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; In N,N-dimethyl-formamide; at 40℃; for 3h; | General procedure: A solution containing DMF (30 mL), alkene (15.85 g, 149.3 mmol), and methyl dichloroacetate (28.6 g, 200 mmol) was added to a flask containing K2CO3 (45.39 g), benzyltriethylammonium chloride (1.65 g, 1.49 mmol), and DMF (100 mL) over 3 h via a dropping funnel modified with an Ace Glass Valve at 40 C. Water (200 mL) was added and the solution was washed with ether (3 × 100 mL). After drying (MgSO4), filtering, and evaporating the ether, the product was vacuum distilled. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
55% | With silver(I) acetate; triethylamine; In toluene; at 25℃; for 24h;Darkness;Catalytic behavior; | General procedure: Ethyl glyoxylate (100 muL, 0.5 mmol, 50% in toluene) or 2,2-dimethoxyacetaldehyde (75 muL, 0.5 mmol, 50% in water), or phenylglyoxal monohydrate (58 muL, 0.5 mmol); diethyl aminomalonate hydrochloride or the amino acid ethyl ester hydrochloride (0.5 mmol), the corresponding dipolarophile (0.5 mmol), AgOAc (4.1 mg, 0.025 mmol) and triethylamine (90 muL, 0.55 mmol) were dissolved in toluene (4 mL). The reaction vessel was covered with an aluminium foil in order to prevent the light exposure. Once the reaction was judged complete after a TLC test the solvent was evaporated under reduced pressure and the residue was dissolved in ethyl acetate, washed with brine and dried over MgSO4. After evaporation the residue was purified by flash chromatography (silica gel) to afford the corresponding product. The reaction involving ethyl glyoxylate and 2,2-dimethoxyacetaldehyde were scaled up 10 times to afford endo-cis-3a and endo-cis-5a in 80% and 75%, respectively. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
38% | With silver(I) acetate; triethylamine; In toluene; at 25℃; for 24h;Darkness;Catalytic behavior; | General procedure: Ethyl glyoxylate (100 muL, 0.5 mmol, 50% in toluene) or 2,2-dimethoxyacetaldehyde (75 muL, 0.5 mmol, 50% in water), or phenylglyoxal monohydrate (58 muL, 0.5 mmol); diethyl aminomalonate hydrochloride or the amino acid ethyl ester hydrochloride (0.5 mmol), the corresponding dipolarophile (0.5 mmol), AgOAc (4.1 mg, 0.025 mmol) and triethylamine (90 muL, 0.55 mmol) were dissolved in toluene (4 mL). The reaction vessel was covered with an aluminium foil in order to prevent the light exposure. Once the reaction was judged complete after a TLC test the solvent was evaporated under reduced pressure and the residue was dissolved in ethyl acetate, washed with brine and dried over MgSO4. After evaporation the residue was purified by flash chromatography (silica gel) to afford the corresponding product. The reaction involving ethyl glyoxylate and 2,2-dimethoxyacetaldehyde were scaled up 10 times to afford endo-cis-3a and endo-cis-5a in 80% and 75%, respectively. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
71% | With tributylphosphine; In tetrahydrofuran; at 20℃; for 48h; | Example 1 Preparation of methyl (3E,5E)-3-(methoxycarbonyl)-3,5-tridecadienoate (58) n-Bu3P (7.12 g, 35.2 mmoles) was added to a solution of dimethyl fumarate (3.97 g, 27.6 mmoles) and (E)-2-decenal (3.89 g, 25.2 mmoles) in THF (44 ml). The mixture was stirred at room temperature for 48 hours. After that time, AcOEt (30 ml) and H2O (30 ml) were added. The phases were separated, and the aqueous phase was extracted with AcOEt (3 * 25 ml). The organic phase was dried with anhydrous Na2SO4, filtered and the solvent was removed under reduced pressure. The product was purified by a chromatographic column (hexane/AcOEt, 20:1), obtaining (5.03 g, yield 71%) methyl (3E,5E)-3-(methoxycarbonyl)-3,5-tridecadienoate (58), as a transparent oil. IR(NaCl): nu 2949, 2928, 2856, 1744, 1714, 1641, 1436, 1324, 1258, 1198, 1170, 1085, 975 cm-1. 1H-NMR (200 MHz, CDCl3). delta 7.33 (1H, d, J = 10.4 Hz, H-4), 6.22 (1H, dt, J = 7.0, 15.1 Hz, H-6), 6.20 (1H, dd, J = 10.4, 15.1 Hz, H-5), 3.75 (3H, s, -OCH3), 3.68 (3H, s,-OCH3), 3.43 (2H, s, H-2), 2.18 (2H, m, H-7), 1.40-1.20 (10H, m, -CH2-), 0.87 (3H, m,-CH3). 13C-NMR (50 MHz,CDCl3). delta 171.0, 167.6, 145.8, 141.5, 124.9, 121.5, 51.7, 51.6, 33.1, 32.0, 31.5, 28.9, 28.8, 28.5, 22.4, 13.9. LRMS(EI): m/z 282(M+, 28), 251(16), 222(12),190(8),183(100),166(12),137(43). E.A. (C16H26O4): Found: C, 68.20, H, 9.30; Calculated: C, 68.06, H, 9.28. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
38% | With 1-butyl-3-methylimidazolium Tetrafluoroborate; In tetrachloromethane; at 20℃; for 48h; | General procedure: [bmim]BF4 (0.051 g, 0.228 mmol) and the appropriate dipolarophile (2.85 mmol) were added to the DNFO solution (0.57 mmol) in CCl4 (2 ml) with stirring at room temperature. The mixture was stirred for the time indicated in Table 2. Next, H2O (5 ml) was added, and the organic layer was separated and dried over MgSO4. The solvent was evaporated under reduced pressure and the residue was purified by column chromatography on silica gel (eluent-CH2Cl2/CCl4). Caution Dinitrofuroxan must be used only as a solution in CCl4 due to its propensity to explode |
38% | With 1-butyl-3-methylimidazolium Tetrafluoroborate; In tetrachloromethane; at 20℃; for 48h; | General procedure: To a stirred solution of dinitrofuroxan (100 mg, 0.57 mmol) in CCl4 (2 mL), [bmim]BF4(51 mg, 0.228 mmol) and the corresponding dipolarophile(2.85 mmol) were added at room temperature. The reactionwas carried out and the products were isolated following themethod A.Caution Dinitrofuroxan has to be used only in solution inCCl4 due to its tendency to explode. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
85% | A 50 ml round bottomed flask was charged with 2-(3,6-dihydro-2H-pyran-4-yl)-4,4,5,5- tetramethyl-l,3,2-dioxaborolane (1.02 g, 4.86 mmol), sodium bicarbonate (146 mg, 1.73 mmol), and chloro(l,5-cyclooctadiene)rhodium (I) dimer (68 mg, 0.14 mmol). Then added 1,4-dioxane (10 ml) and water (1.7 ml). Most solids dissolved into an orange solution. The reaction mixture was stirred at room temperature for 15 min then dimethyl fumarate (500 mg, 3.47 mmol) was added. The yellow reaction mixture was heated at 50C for 1 h then at 100C for 1 h during which time a dark maroon color was observed. The reaction was cooled to room temperature and diluted with water then extracted with EtOAc. The combined organics were washed with sat'd NaHCC>3 and water then dried over MgS04 and concentrated. The crude residue was absorbed on silica gel and purified by chromatography (20% to 30% EtOAc/hexanes) to isolate 676 mg (85%) of 2-(3,6-dihydro-2H-pyran-4-yl)-succinic acid dimethyl ester as a light yellow oil. 1H NMR (300 MHz, CDC13) delta: 5.65 (dd, J = 2.6, 1.5 Hz, 1H), 4.07 - 4.20 (m, 2H), 3.73 - 3.82 (m, 2H), 3.72 (s, 3H), 3.69 (s, 3H), 3.50 (dd, J = 9.8, 5.7 Hz, 1H), 2.95 (dd, J = 16.6, 9.8 Hz, 1H), 2.52 (dd, J = 16.6, 5.7 Hz, 1H), 1.97 - 2.24 (m, 2H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With silver(I) acetate; triethylamine; In toluene; at 25℃; for 24h;Darkness;Catalytic behavior; | General procedure: Ethyl glyoxylate (100 muL, 0.5 mmol, 50% in toluene) or 2,2-dimethoxyacetaldehyde (75 muL, 0.5 mmol, 50% in water), or phenylglyoxal monohydrate (58 muL, 0.5 mmol); diethyl aminomalonate hydrochloride or the amino acid ethyl ester hydrochloride (0.5 mmol), the corresponding dipolarophile (0.5 mmol), AgOAc (4.1 mg, 0.025 mmol) and triethylamine (90 muL, 0.55 mmol) were dissolved in toluene (4 mL). The reaction vessel was covered with an aluminium foil in order to prevent the light exposure. Once the reaction was judged complete after a TLC test the solvent was evaporated under reduced pressure and the residue was dissolved in ethyl acetate, washed with brine and dried over MgSO4. After evaporation the residue was purified by flash chromatography (silica gel) to afford the corresponding product. The reaction involving ethyl glyoxylate and 2,2-dimethoxyacetaldehyde were scaled up 10 times to afford endo-cis-3a and endo-cis-5a in 80% and 75%, respectively. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
11%; 70% | With triethylamine; In toluene; at 70℃; for 17h; | General procedure: To a solution of the pipecolic acid methyl ester hydrochloride 1 (40mg, 0.22 mmol) in toluene (1 mL), Et3N (30.5 muL, 0.22 mmol, 1 equiv), the corresponding aldehyde (0.22 mmol, 1 equiv) and the dipolarophile (0.22 mmol, 1 equiv) were added. The resulting mixture was stirred at 70 C for 17 h. EtOAc (5 mL) and H2O (5 mL) were added and the organic phase was separated, dried (MgSO4), and evaporated to afford the crude heterocycle, which was purified by flash chromatography(silica gel) in the chemical yields reported in the text. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
39% | With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 25℃; for 3h; | In a 100 ml flask with an inlet of four, 9.5 g (0.06 mol) of diazabicyclo undecene (DBU) , 18 ml of acetonitrile, 17.1 g (0.14 mol) of <strong>[50790-93-7]2-butylimidazole</strong> was added and the mixture was stirred at 25 C. In addition, 18.0 g (0.12 mol) of dimethyl fumarate was added dropwise and reacted at 25 DEG C for 3 hours. After completion of the reaction, the Extraction was carried out with 70 ml of methylene chloride and 50 ml of water, after removing the solvent under reduced pressure. The collected organic layer was concentrated by separation, and the obtained concentrate was purified by silica gel column chromatography (ethyl acetate / hexane = 1/1) , to obtain 2- (2-butyl-imidazol-1-yl) dimethyl succinate as a liquid phase. The obtained 2- (2-butyl-imidazol-1-yl) dimethyl succinate, yield 13.1g was 39%.2- (2-butylimidazol-1-yl) succinic acid dimethyl, and a release reaction of the protective group start under a temperature condition of 179 , and the disappearance of dimethyl succinate in 2- (2-butyl-imidazol-1-yl) dimethyl succinate was confirmed by NMR analysis. In addition, in GC analysis, it was confirmed that dimethyl fumarate originating from the leaving protecting group A was produced. |
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P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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