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[ CAS No. 627-01-0 ] {[proInfo.proName]}

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Chemical Structure| 627-01-0
Chemical Structure| 627-01-0
Structure of 627-01-0 * Storage: {[proInfo.prStorage]}
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Product Details of [ 627-01-0 ]

CAS No. :627-01-0 MDL No. :MFCD00037794
Formula : C4H9NO2 Boiling Point : -
Linear Structure Formula :- InChI Key :YPIGGYHFMKJNKV-UHFFFAOYSA-N
M.W : 103.12 Pubchem ID :316542
Synonyms :

Safety of [ 627-01-0 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 627-01-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 627-01-0 ]
  • Downstream synthetic route of [ 627-01-0 ]

[ 627-01-0 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 627-01-0 ]
  • [ 13733-17-0 ]
  • [ 22884-10-2 ]
Reference: [1] Journal of the Chemical Society, 1932, p. 1806,1809
  • 2
  • [ 627-01-0 ]
  • [ 24424-99-5 ]
  • [ 149794-10-5 ]
YieldReaction ConditionsOperation in experiment
100% With sodium carbonate In 1,2-dimethoxyethane; water for 4 h; 2-[(tert-butoxy)-N-ethylcarbonylamino]acetic Acid A solution of di-tert-butyl dicarbonate (2.18 g, 12.5 mmol) in dimethoxyethane (30 mL) was added to a stirred solution of 2-(ethylamino)acetic acid in Na2CO3 (1.04 g, 10 mmol in water, 30 mL). Stirring was continued for 4 h, then the reaction mixture was acidified with hydrochloric acid (1 N, 30 mL) and extracted with ethyl acetate (3.x.30 mL). The organic layers were dried over Na2SO4 and concentrated in vacuo to give 2-[(tert-butoxy)-N-ethylcarbonylamino]acetic acid as a colorless oil with quantitative yield. 1H NMR (CDCl3), δ 3.95 (m, 2H), 3.30 (m, 2H), 1.45 (m, 9H), 1.12 (t, J=7.2 Hz, 3H).
100% With sodium carbonate In 1,2-dimethoxyethane; water for 4 h; A solution of di-tert-butyl dicarbonate (2.18 g, 12.5 mmol) in dimethoxyethane (30 mL) was added to a stirred solution of 2-(ethylamino)acetic acid in Na2CO3 (1.04 g, 10 mmol in water, 30 mL). Stirring was continued for 4 h, then the reaction mixture was acidified with hydrochloric acid (1 N, 30 mL) and extracted with ethyl acetate (3.x.30 mL). The organic layers were dried over Na2SO4 and concentrated in vacuo to give 2-[(tert-butoxy)-N-ethylcarbonylamino]acetic acid as a colorless oil in quantitative yield. 1H NMR (CDCl3), δ 3.95 (m, 2H), 3.30 (m, 2H), 1.45 (m, 9H), 1.12 (t, J=7.2 Hz, 3H).
Reference: [1] Patent: US2006/79522, 2006, A1, . Location in patent: Page/Page column 12
[2] Patent: US2006/79524, 2006, A1, . Location in patent: Page/Page column 13
[3] Journal of Medicinal Chemistry, 2004, vol. 47, # 3, p. 681 - 695
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