[ CAS No. 627463-17-6 ] {[proInfo.proName]}

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2D 3D

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Quality Control of [ 627463-17-6 ]

COA NMR CNMR HPLC LC-MS

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Product Details of [ 627463-17-6 ]

CAS No. :	627463-17-6	MDL No. :	MFCD09907860
Formula :	C₈H₆BrF	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	201.04	Pubchem ID :	-
Synonyms :

Safety of [ 627463-17-6 ]

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Application In Synthesis of [ 627463-17-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 627463-17-6 ]

[ 627463-17-6 ] Synthesis Path-Downstream 1~3

1
[ 627463-17-6 ]
[ 627463-18-7 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogen;palladium 10% on activated carbon; In ethyl acetate; under 760.051 Torr;	4-Bromo-2-fluoro-1-vinyl-benzene (1.80 g, 8.96 mmol) was dissolved in ethyl acetate (50 mL) and palladium-on-carbon (10%, 70 mg) was added and the mixture was hydrogenated under 1 atmosphere overnight. The mixture was filtered and the filtrate was concentrated to give the crude, 1.80 g, which was used directly for the next step.

Reference： [1]Patent: US2004/6058,2004,A1 .Location in patent: Page/Page column 26

2
[ 623-73-4 ]
[ 627463-17-6 ]
[ 934995-82-1 ]
C₁₂H₁₂BrFO₂ [ No CAS ]
[ 623-91-6 ]
[ 141-05-9 ]

Yield	Reaction Conditions	Operation in experiment
1: 99 % ee 2: 96%	With aluminum oxide; potassium carbonate In chloroform at 0 - 20℃; for 24 - 25h;	2.1. Cyclopropanation and Purification of Compound 3; An improved Evans cyclopropanation protocol was used for this synthesis using the Cu catalyst prepared from copper (I) triflate and chiral ligand 10. Other ligands and Rh catalysts were tried but all afforded lower diastereoselectivity. The major by-products from the reaction were the cis-isomer, 11 and 12 from the dimerization of ethyl diazoacetate. Solvent plays a significant role in enantioselectivity, diastereoselectivity, and formation of the dimer impurities. As shown in Table 1, a variety of solvents, including coordinating and non-coordinating ones, gave good to excellent conversions (74-98%), except for THF (45%). The diastereoselectivity varied from 80:20 (trans:cis, 1,2-dichloroethane) to 93:7 (trans:cis, MTBE), and ee varied from 85% (1,2-dichloroethane) to 99% (many solvents including MTBE). MTBE gave the best results and was used as the solvent for our first GMP campaign. A significant amount of precipitate was formed when the catalyst was prepared in MTBE. In early studies, this precipitate was removed by filtration prior to the cyclopropanation. However, conversions and ethyl diazoacetate accumulation varied from batch to batch. The situation was greatly improved by generation of the catalyst in situ without filtration. The solid catalyst was completely dissolved after the addition of styrene, giving a clear solution before addition of ethyl diazoacetate. Similar diastereoselectivity and enantioselectivity were obtained. In the prep lab, the cyclopropanation reaction was run in two batches. The first batch used the procedure with the solid catalyst removed and 2.4 kg (assayed, 85% yield after NaBH4 treatment, see below) of 3 was obtained with a trans/cis ratio of 92:8 and 98.8% ee for the trans. The conversion for the reaction was only 95% with 2.0 equiv of ethyl diazoacetate used. The second batch used the procedure with in situ generated catalyst without solid removal. Complete conversion was observed with the use of 1.5 equiv of ethyl diazoacetate. Again, 2.4 kg (assayed, 85% yield after NaBH4 treatment) of 3 was obtained with a trans/cis ratio of 88:12 and 98.9% ee for the trans.
1: 99 % ee 2: 97 % ee	In ethyl acetate at 0 - 20℃; for 24 - 25h;	2.1. Cyclopropanation and Purification of Compound 3; An improved Evans cyclopropanation protocol was used for this synthesis using the Cu catalyst prepared from copper (I) triflate and chiral ligand 10. Other ligands and Rh catalysts were tried but all afforded lower diastereoselectivity. The major by-products from the reaction were the cis-isomer, 11 and 12 from the dimerization of ethyl diazoacetate. Solvent plays a significant role in enantioselectivity, diastereoselectivity, and formation of the dimer impurities. As shown in Table 1, a variety of solvents, including coordinating and non-coordinating ones, gave good to excellent conversions (74-98%), except for THF (45%). The diastereoselectivity varied from 80:20 (trans:cis, 1,2-dichloroethane) to 93:7 (trans:cis, MTBE), and ee varied from 85% (1,2-dichloroethane) to 99% (many solvents including MTBE). MTBE gave the best results and was used as the solvent for our first GMP campaign. A significant amount of precipitate was formed when the catalyst was prepared in MTBE. In early studies, this precipitate was removed by filtration prior to the cyclopropanation. However, conversions and ethyl diazoacetate accumulation varied from batch to batch. The situation was greatly improved by generation of the catalyst in situ without filtration. The solid catalyst was completely dissolved after the addition of styrene, giving a clear solution before addition of ethyl diazoacetate. Similar diastereoselectivity and enantioselectivity were obtained. In the prep lab, the cyclopropanation reaction was run in two batches. The first batch used the procedure with the solid catalyst removed and 2.4 kg (assayed, 85% yield after NaBH4 treatment, see below) of 3 was obtained with a trans/cis ratio of 92:8 and 98.8% ee for the trans. The conversion for the reaction was only 95% with 2.0 equiv of ethyl diazoacetate used. The second batch used the procedure with in situ generated catalyst without solid removal. Complete conversion was observed with the use of 1.5 equiv of ethyl diazoacetate. Again, 2.4 kg (assayed, 85% yield after NaBH4 treatment) of 3 was obtained with a trans/cis ratio of 88:12 and 98.9% ee for the trans.
1: 99 % ee 2: 97 % ee	In toluene at 0 - 20℃; for 24 - 25h; Molecular sieve;	2.1. Cyclopropanation and Purification of Compound 3; An improved Evans cyclopropanation protocol was used for this synthesis using the Cu catalyst prepared from copper (I) triflate and chiral ligand 10. Other ligands and Rh catalysts were tried but all afforded lower diastereoselectivity. The major by-products from the reaction were the cis-isomer, 11 and 12 from the dimerization of ethyl diazoacetate. Solvent plays a significant role in enantioselectivity, diastereoselectivity, and formation of the dimer impurities. As shown in Table 1, a variety of solvents, including coordinating and non-coordinating ones, gave good to excellent conversions (74-98%), except for THF (45%). The diastereoselectivity varied from 80:20 (trans:cis, 1,2-dichloroethane) to 93:7 (trans:cis, MTBE), and ee varied from 85% (1,2-dichloroethane) to 99% (many solvents including MTBE). MTBE gave the best results and was used as the solvent for our first GMP campaign. A significant amount of precipitate was formed when the catalyst was prepared in MTBE. In early studies, this precipitate was removed by filtration prior to the cyclopropanation. However, conversions and ethyl diazoacetate accumulation varied from batch to batch. The situation was greatly improved by generation of the catalyst in situ without filtration. The solid catalyst was completely dissolved after the addition of styrene, giving a clear solution before addition of ethyl diazoacetate. Similar diastereoselectivity and enantioselectivity were obtained. In the prep lab, the cyclopropanation reaction was run in two batches. The first batch used the procedure with the solid catalyst removed and 2.4 kg (assayed, 85% yield after NaBH4 treatment, see below) of 3 was obtained with a trans/cis ratio of 92:8 and 98.8% ee for the trans. The conversion for the reaction was only 95% with 2.0 equiv of ethyl diazoacetate used. The second batch used the procedure with in situ generated catalyst without solid removal. Complete conversion was observed with the use of 1.5 equiv of ethyl diazoacetate. Again, 2.4 kg (assayed, 85% yield after NaBH4 treatment) of 3 was obtained with a trans/cis ratio of 88:12 and 98.9% ee for the trans.

1: 85 % ee 2: 94 % ee	In 1,2-dichloro-ethane at 0 - 20℃; for 24 - 25h; Molecular sieve;	2.1. Cyclopropanation and Purification of Compound 3; An improved Evans cyclopropanation protocol was used for this synthesis using the Cu catalyst prepared from copper (I) triflate and chiral ligand 10. Other ligands and Rh catalysts were tried but all afforded lower diastereoselectivity. The major by-products from the reaction were the cis-isomer, 11 and 12 from the dimerization of ethyl diazoacetate. Solvent plays a significant role in enantioselectivity, diastereoselectivity, and formation of the dimer impurities. As shown in Table 1, a variety of solvents, including coordinating and non-coordinating ones, gave good to excellent conversions (74-98%), except for THF (45%). The diastereoselectivity varied from 80:20 (trans:cis, 1,2-dichloroethane) to 93:7 (trans:cis, MTBE), and ee varied from 85% (1,2-dichloroethane) to 99% (many solvents including MTBE). MTBE gave the best results and was used as the solvent for our first GMP campaign. A significant amount of precipitate was formed when the catalyst was prepared in MTBE. In early studies, this precipitate was removed by filtration prior to the cyclopropanation. However, conversions and ethyl diazoacetate accumulation varied from batch to batch. The situation was greatly improved by generation of the catalyst in situ without filtration. The solid catalyst was completely dissolved after the addition of styrene, giving a clear solution before addition of ethyl diazoacetate. Similar diastereoselectivity and enantioselectivity were obtained. In the prep lab, the cyclopropanation reaction was run in two batches. The first batch used the procedure with the solid catalyst removed and 2.4 kg (assayed, 85% yield after NaBH4 treatment, see below) of 3 was obtained with a trans/cis ratio of 92:8 and 98.8% ee for the trans. The conversion for the reaction was only 95% with 2.0 equiv of ethyl diazoacetate used. The second batch used the procedure with in situ generated catalyst without solid removal. Complete conversion was observed with the use of 1.5 equiv of ethyl diazoacetate. Again, 2.4 kg (assayed, 85% yield after NaBH4 treatment) of 3 was obtained with a trans/cis ratio of 88:12 and 98.9% ee for the trans.
1: 99 % ee 2: 97 % ee	In tert-butyl methyl ether at 0 - 20℃; for 24 - 25h; Molecular sieve;	2.1. Cyclopropanation and Purification of Compound 3; An improved Evans cyclopropanation protocol was used for this synthesis using the Cu catalyst prepared from copper (I) triflate and chiral ligand 10. Other ligands and Rh catalysts were tried but all afforded lower diastereoselectivity. The major by-products from the reaction were the cis-isomer, 11 and 12 from the dimerization of ethyl diazoacetate. Solvent plays a significant role in enantioselectivity, diastereoselectivity, and formation of the dimer impurities. As shown in Table 1, a variety of solvents, including coordinating and non-coordinating ones, gave good to excellent conversions (74-98%), except for THF (45%). The diastereoselectivity varied from 80:20 (trans:cis, 1,2-dichloroethane) to 93:7 (trans:cis, MTBE), and ee varied from 85% (1,2-dichloroethane) to 99% (many solvents including MTBE). MTBE gave the best results and was used as the solvent for our first GMP campaign. A significant amount of precipitate was formed when the catalyst was prepared in MTBE. In early studies, this precipitate was removed by filtration prior to the cyclopropanation. However, conversions and ethyl diazoacetate accumulation varied from batch to batch. The situation was greatly improved by generation of the catalyst in situ without filtration. The solid catalyst was completely dissolved after the addition of styrene, giving a clear solution before addition of ethyl diazoacetate. Similar diastereoselectivity and enantioselectivity were obtained. In the prep lab, the cyclopropanation reaction was run in two batches. The first batch used the procedure with the solid catalyst removed and 2.4 kg (assayed, 85% yield after NaBH4 treatment, see below) of 3 was obtained with a trans/cis ratio of 92:8 and 98.8% ee for the trans. The conversion for the reaction was only 95% with 2.0 equiv of ethyl diazoacetate used. The second batch used the procedure with in situ generated catalyst without solid removal. Complete conversion was observed with the use of 1.5 equiv of ethyl diazoacetate. Again, 2.4 kg (assayed, 85% yield after NaBH4 treatment) of 3 was obtained with a trans/cis ratio of 88:12 and 98.9% ee for the trans.
	In Isopropyl acetate at 0 - 20℃; for 24 - 25h; Molecular sieve;	2.1. Cyclopropanation and Purification of Compound 3; An improved Evans cyclopropanation protocol was used for this synthesis using the Cu catalyst prepared from copper (I) triflate and chiral ligand 10. Other ligands and Rh catalysts were tried but all afforded lower diastereoselectivity. The major by-products from the reaction were the cis-isomer, 11 and 12 from the dimerization of ethyl diazoacetate. Solvent plays a significant role in enantioselectivity, diastereoselectivity, and formation of the dimer impurities. As shown in Table 1, a variety of solvents, including coordinating and non-coordinating ones, gave good to excellent conversions (74-98%), except for THF (45%). The diastereoselectivity varied from 80:20 (trans:cis, 1,2-dichloroethane) to 93:7 (trans:cis, MTBE), and ee varied from 85% (1,2-dichloroethane) to 99% (many solvents including MTBE). MTBE gave the best results and was used as the solvent for our first GMP campaign. A significant amount of precipitate was formed when the catalyst was prepared in MTBE. In early studies, this precipitate was removed by filtration prior to the cyclopropanation. However, conversions and ethyl diazoacetate accumulation varied from batch to batch. The situation was greatly improved by generation of the catalyst in situ without filtration. The solid catalyst was completely dissolved after the addition of styrene, giving a clear solution before addition of ethyl diazoacetate. Similar diastereoselectivity and enantioselectivity were obtained. In the prep lab, the cyclopropanation reaction was run in two batches. The first batch used the procedure with the solid catalyst removed and 2.4 kg (assayed, 85% yield after NaBH4 treatment, see below) of 3 was obtained with a trans/cis ratio of 92:8 and 98.8% ee for the trans. The conversion for the reaction was only 95% with 2.0 equiv of ethyl diazoacetate used. The second batch used the procedure with in situ generated catalyst without solid removal. Complete conversion was observed with the use of 1.5 equiv of ethyl diazoacetate. Again, 2.4 kg (assayed, 85% yield after NaBH4 treatment) of 3 was obtained with a trans/cis ratio of 88:12 and 98.9% ee for the trans.
	In α,α,α-trifluorotoluene at 0 - 20℃; for 24 - 25h;	2.1. Cyclopropanation and Purification of Compound 3; An improved Evans cyclopropanation protocol was used for this synthesis using the Cu catalyst prepared from copper (I) triflate and chiral ligand 10. Other ligands and Rh catalysts were tried but all afforded lower diastereoselectivity. The major by-products from the reaction were the cis-isomer, 11 and 12 from the dimerization of ethyl diazoacetate. Solvent plays a significant role in enantioselectivity, diastereoselectivity, and formation of the dimer impurities. As shown in Table 1, a variety of solvents, including coordinating and non-coordinating ones, gave good to excellent conversions (74-98%), except for THF (45%). The diastereoselectivity varied from 80:20 (trans:cis, 1,2-dichloroethane) to 93:7 (trans:cis, MTBE), and ee varied from 85% (1,2-dichloroethane) to 99% (many solvents including MTBE). MTBE gave the best results and was used as the solvent for our first GMP campaign. A significant amount of precipitate was formed when the catalyst was prepared in MTBE. In early studies, this precipitate was removed by filtration prior to the cyclopropanation. However, conversions and ethyl diazoacetate accumulation varied from batch to batch. The situation was greatly improved by generation of the catalyst in situ without filtration. The solid catalyst was completely dissolved after the addition of styrene, giving a clear solution before addition of ethyl diazoacetate. Similar diastereoselectivity and enantioselectivity were obtained. In the prep lab, the cyclopropanation reaction was run in two batches. The first batch used the procedure with the solid catalyst removed and 2.4 kg (assayed, 85% yield after NaBH4 treatment, see below) of 3 was obtained with a trans/cis ratio of 92:8 and 98.8% ee for the trans. The conversion for the reaction was only 95% with 2.0 equiv of ethyl diazoacetate used. The second batch used the procedure with in situ generated catalyst without solid removal. Complete conversion was observed with the use of 1.5 equiv of ethyl diazoacetate. Again, 2.4 kg (assayed, 85% yield after NaBH4 treatment) of 3 was obtained with a trans/cis ratio of 88:12 and 98.9% ee for the trans.

Reference： [1]Current Patent Assignee: MERCK & CO INC - US2007/99951, 2007, A1 Location in patent: Page/Page column 18-19
[2]Current Patent Assignee: MERCK & CO INC - US2007/99951, 2007, A1 Location in patent: Page/Page column 18-20
[3]Current Patent Assignee: MERCK & CO INC - US2007/99951, 2007, A1 Location in patent: Page/Page column 18-19
[4]Current Patent Assignee: MERCK & CO INC - US2007/99951, 2007, A1 Location in patent: Page/Page column 18-19
[5]Current Patent Assignee: MERCK & CO INC - US2007/99951, 2007, A1 Location in patent: Page/Page column 18-20
[6]Current Patent Assignee: MERCK & CO INC - US2007/99951, 2007, A1 Location in patent: Page/Page column 18-20
[7]Current Patent Assignee: MERCK & CO INC - US2007/99951, 2007, A1 Location in patent: Page/Page column 18-20

3
[ 3536-96-7 ]
[ 105931-73-5 ]
[ 627463-17-6 ]

Yield	Reaction Conditions	Operation in experiment
80%	With zinc(II) chloride In tetrahydrofuran at -5 - 20℃; for 4.16 - 6.16h;	1.3.1; 1 To a 72 L round bottomed flask was added zinc chloride THF solution (0.5 M, 33.2 L, 16.62 mol). The solution was cooled to -5° C. and vinyl magnesium chloride THF solution (1.6 M, 20.80 L, 33.24 mol) was added slowly, maintaining temperature at less than 20° C. Triphenylphosphine (149.5 g, 0.570 mol) was added, followed by Pd(PPh3)2Cl2 (200 g, 0.285 mol). The mixture was stirred for 10 min, and 1-Bromo-3-fluoro-4-iodobenzene was added. The reaction mixture was stirred at ambient temperature for 4-6 h until the reaction was complete by HPLC. Mixing zinc chloride and vinyl magnesium chloride THF solutions was exothermic. The temperature was controlled by adjusting the addition rate and the cooling bath temperature. The coupling reaction after the addition of aryl iodide (1) was slightly exorthermic. The temperature rose from 11° C. to 37° C. without a cooling bath in about 1 h and it cooled down thereafter. The reaction mixture was quenched into a pre-cooled (0° C.) mixture of pentane (20 L), water (12 L), and concentrated HCl (1.0 L) in a 200 L extractor. The two layers were separated. The organic layer was diluted with pentane (20 L), washed with water (16 L), and concentrated under reduced pressure. Compound 2 was quite volatile, and 20% was lost during rotavap concentration. Assay of the product before concentration normally gave product yield of 80-85%. The product was further purified in this way: The residue was taken up with pentane (10 L). The resulting suspension was filtered. The solid was washed with pentane (1.0 L). The combined filtrate and wash were concentrated. The crude oil was purified by vacuum distillation at 0.1-0.2 mm Hg. Purified product was light yellow with a boiling point of 45-50° C. at 0.1-0.2 mm Hg. Distillation recovery was 95%. Product was 93-95 wt %. The residue in the distillation pot was liquid at the end of distillation, but solidified upon cooling
80%	Stage #1: vinylmagnesium chloride With zinc(II) chloride In tetrahydrofuran at -5 - 20℃; for 0.166667h; Stage #2: 1-bromo-3-fluoro-4-iodobenzene In tetrahydrofuran at 11 - 37℃; for 4 - 6h;	3.1 3.1. Preparation of Styrene Compound 2; Materials MW Amount Moles 1-Bromo-3-fluoro-4-iodobenzene 300.89 5.0 kg 16.62 Vinyl magnesium chloride3 1.6 M in THF 20.80 L 33.24 Zinc chloride 0.5 M in THF 33.2 L 16.62Pd(PPh3)2Cl2 701.89 200 g 0.285PPh3 262.29 149.5 g 0.570 Pentane 40 L To a 72 L round bottomed flask was added zinc chloride THF solution (0.5 M, 33.2 L, 16.62 mol). The solution was cooled to -5° C. and vinyl magnesium chloride THF solution (1.6 M, 20.80 L, 33.24 mol) was added slowly, maintaining temperature at less than 20° C. Triphenylphosphine (149.5 g, 0.570 mol) was added, followed by Pd(PPh3)2Cl2 (200 g, 0.285 mol). The mixture was stirred for 10 min, and 1-Bromo-3-fluoro-4-iodobezene was added. The reaction mixture was stirred at ambient temperature for 4-6 h until the reaction was complete by HPLC. Mixing zinc chloride and vinyl magnesium chloride THF solutions was exothermic. The temperature was controlled by adjusting the addition rate and the cooling bath temperature. The coupling reaction after the addition of aryl iodide (1) was slightly exorthermic. The temperature rose from 11° C. to 37° C. without a cooling bath in about 1 h and it cooled down thereafter. The reaction mixture was quenched into a pre-cooled (0° C.) mixture of pentane (20 L), water (12 L), and concentrated HCl (1.0 L) in a 200 L extractor. The two layers were separated. The organic layer was diluted with pentane (20 L), washed with water (16 L), and concentrated under reduced pressure. Compound 2 was quite volatile, and 20% was lost during rotavap concentration. Assay of the product before concentration normally gave product yield of 80-85%. The product was further purified in this way: The residure was taken up with pentane (10 L). The resulting suspension was filtered. The solid was washed with pentane (1.0 L). The combined filtrate and wash were concentrated. The crude oil was purified by vacuum distillation at 0.1-0.2 mm Hg. Purified product was light yellow with a boiling point of 45-50° C. at 0.1-0.2 mm Hg. Distillation recovery was 95%. Product was 93-95 wt %. The residue in the distillation pot was liquid at the end of distillation, but solidified upon cooling

Reference： [1]Current Patent Assignee: MERCK & CO INC - US2009/105479, 2009, A1 Location in patent: Page/Page column 11; 17
[2]Current Patent Assignee: MERCK & CO INC - US2007/99951, 2007, A1 Location in patent: Page/Page column 11-12

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P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 627463-17-6 ] {[proInfo.proName]}

Quality Control of [ 627463-17-6 ]

Related Doc. of [ 627463-17-6 ]

Product Details of [ 627463-17-6 ]

Safety of [ 627463-17-6 ]

Application In Synthesis of [ 627463-17-6 ]

[ 627463-17-6 ] Synthesis Path-Downstream 1~3

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry