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[ CAS No. 6342-21-8 ]

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Cat. No.: {[proInfo.prAm]}
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type HazMat fee
Excepted Quantity Free
Inaccessible (Haz class 6.1), Domestic USD 41.00
Inaccessible (Haz class 6.1), International USD 64.00
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 83.00
Accessible (Haz class 3, 4, 5 or 8), International USD 133.00
2D
Chemical Structure| 6342-21-8
Chemical Structure| 6342-21-8
Structure of 6342-21-8 *Storage: {[proInfo.prStorage]}

Quality Control of [ 6342-21-8 ]

Related Doc. of [ 6342-21-8 ]

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Alternatived Products of [ 6342-21-8 ]
Alternatived Products of [ 6342-21-8 ]

Product Details of [ 6342-21-8 ]

CAS No. :6342-21-8MDL No. :MFCD01631934
Formula : C10H16N2 Boiling Point : -
Linear Structure Formula :-InChI Key :-
M.W :164.25Pubchem ID :-
Synonyms :

Computed Properties of [ 6342-21-8 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 6342-21-8 ]

Signal Word:DangerClass:8
Precautionary Statements:P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P405-P501UN#:2735
Hazard Statements:H314Packing Group:
GHS Pictogram:

Application In Synthesis of [ 6342-21-8 ]

  • Downstream synthetic route of [ 6342-21-8 ]

[ 6342-21-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6342-21-8 ]
  • [ 39226-97-6 ]
  • C18H19F3N2O [ No CAS ]
YieldReaction ConditionsOperation in experiment
70% With triethylamine; In tetrahydrofuran; at 0 - 20℃; for 18.5h;Inert atmosphere; As shown in reaction scheme 83, N,N-dimethyl-1-phenylethane-1,2-diamine represented by Formula 101 (439.1 mg, 2.67 mmol, purchased from Alfa Aesar Co.) and triethylamine (0.75 mL, 5.35 mmol) in THF (10 mL) solution were cooled to 0C under a nitrogen atmosphere, then, 3-(trifluoromethyl)benzoic acid chloride represented by Formula 153 (613.17 mg, 2.94 mmol, purchased from TCI Co.) in THF (15 mL) solution was slowly added thereto. After agitating the mixture at the same time for 30 minutes, the mixture was left at room temperature for 18 hours. A precipitate generated during the reaction was removed through filtration. The remaining solution was diluted with chloroform and this diluted solution was washed with a potassium carbonate (K2CO3) solution, followed by separation and drying the same with sodium sulfate (Na2SO4). The obtained vacuum-concentrated mixture was subjected to separation and purification through column chromatography (ethyl acetate/hexane/triethylamine, 2:1:0.1, v/v/v) using silica gel (SiO2), resulting in a benzamide compound represented by Formula 83 as a desired product (WZ-078; 632.5 mg, 70% yield). [0357] Analysis data of the produced benzamide compound is provided as follows. Rf(ethyl acetate/hexane/triethylamine, 2:1:0.1, v/v/v) 0.4; HRMS (EI+) calcd for C18H19F3N2O([M+])336.1449, 1H NMR (500 MHz, MeOH-d4) d 2.27 (s, 6 H), 3.70-3.72 (m, 2 H), 4.00 (dd, 1 H, J = 4.5 Hz, 7.5 Hz), 7.28-7.37 (m, 5 H), 7.60 (t, 1 H, J = 8.0 Hz), 7.79 (d, 1 H, J = 7.5 Hz), 7.87 (d, 1 H, J = 7.5 Hz), 7.91 (s, 1 H).
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