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[ CAS No. 63888-94-8 ] {[proInfo.proName]}

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Chemical Structure| 63888-94-8
Chemical Structure| 63888-94-8
Structure of 63888-94-8 * Storage: {[proInfo.prStorage]}
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Product Details of [ 63888-94-8 ]

CAS No. :63888-94-8 MDL No. :MFCD06204302
Formula : C16H16O3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 256.30 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 63888-94-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 63888-94-8 ]

[ 63888-94-8 ] Synthesis Path-Downstream   1~3

  • 2
  • [ 13036-57-2 ]
  • [ 63888-94-8 ]
  • [ 860629-88-5 ]
YieldReaction ConditionsOperation in experiment
53% With lithium hexamethyldisilazane In tetrahydrofuran at 20℃; for 13h; 69.B Step B: 2-(2-Chloro-4-pyrimidinyl)-1-{3-[(phenylmethyl)oxy]phenyl}ethanone; To a solution containing 2.0 g (7.8 mmol) of ethyl 3-[(phenyImethyl)oxy]benzoate and 4.9 ml_ (7.8 mmol) of a 1.6 M solution of 2-chloro-4-methylpyrimidine in THF at 0 0C was slowly added 15.6 mL (15.6 mmol) of a 1.0 M solution of LHMDS in THF. The reaction mixture was allowed to warm to rt and stir for 13 h, quenched by the addition of 10% aqueous HCI and extracted with DCM. The combined organic layers were dried over MgSO4 and filtered, and the solvents were removed under reduced pressure. The residue was subjected to silica gel chromatography, eluting with an EtOAc/hexane mixture, to give 1.4 g (53%) of the title compound of Step B as a yellow oil that exists as a mixture of ketone and enol tautomers: ESIMS: 339.10 (M+H+).
  • 3
  • [ 63888-94-8 ]
  • [ 1700-30-7 ]
YieldReaction ConditionsOperation in experiment
75% With 15-crown-5; (1-(2-(2,3-diisopropyl-1-methylguanidino)ethyl)-3-mesityl-1,3-dihydro-2H-imidazol-2-ylidene)copper(I) chloride; hydrogen; sodium t-butanolate In 1,4-dioxane at 60℃; for 24h; Inert atmosphere;
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