Alternatived Products of [ 65346-04-5 ]
Product Details of [ 65346-04-5 ]
CAS No. : | 65346-04-5 |
MDL No. : | MFCD16038714 |
Formula : |
C7H5N3O
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
147.13
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 65346-04-5 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 65346-04-5 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 65346-04-5 ]
- Downstream synthetic route of [ 65346-04-5 ]
- 1
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[ 100-54-9 ]
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[ 60100-09-6 ]
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[ 65346-04-5 ]
Yield | Reaction Conditions | Operation in experiment |
67% |
With dipotassium peroxodisulfate at 70℃; for 12h; regioselective reaction; |
General experimental procedure for the synthesis Primary carboxamides:
General procedure: In an oven dried glass tube containing a mixture of pyridine 1a (100 mg, 1.26 mmol), and potassium persulphate (683 mg, 2.53 mmol), formamide 2a (2 ml) was added and the reaction mixture was heated at 70 °C. Upon the completion of the reaction (monitored by TLC), saturated sodium bicarbonate solution (5 mL) was added and the crude product was extracted in ethyl acetate (3 X 5 mL). The crude product was purified by column chromatography to furnish compound 3aa as a white crystalline solid (122 mg, 79% yield) |
52% |
With tert.-butylhydroperoxide; sulfuric acid; iron(II) sulfate for 1h; Ambient temperature; |
|
27% |
With sulfuric acid; dihydrogen peroxide; iron(II) sulfate at 50℃; for 1h; |
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Reference:
[1]Mete, Trimbak B.; Singh, Ankit; Bhat, Ramakrishna G.
[Tetrahedron Letters, 2017, vol. 58, # 50, p. 4709 - 4712]
[2]Langhals, Elke; Langhals, Heinz; Ruechardt, Christoph
[Chemische Berichte, 1984, vol. 117, # 3, p. 1259 - 1261]
[3]Bernard, Harald; Buelow, Gerd; Lange, Udo E. W.; Mack, Helmut; Pfeiffer, Thomas; Schaefer, Bernd; Seitz, Werner; Zierke, Thomas
[Synthesis, 2004, # 14, p. 2367 - 2375]
- 2
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[ 41051-03-0 ]
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[ 65346-04-5 ]
Yield | Reaction Conditions | Operation in experiment |
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With ammonia In ethanol at -10℃; |
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Reference:
[1]Bernard, Harald; Buelow, Gerd; Lange, Udo E. W.; Mack, Helmut; Pfeiffer, Thomas; Schaefer, Bernd; Seitz, Werner; Zierke, Thomas
[Synthesis, 2004, # 14, p. 2367 - 2375]
- 3
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[ 17874-78-1 ]
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[ 65346-04-5 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 4 steps
1: SOCl2; DMF / 1,2-dichloro-ethane / Heating
2: NH3 / tetrahydrofuran / -10 °C
3: (CF3CO)2); i-Pr2NEt / CH2Cl2 / 20 °C
4: NH3 / ethanol / -10 °C |
|
Reference:
[1]Bernard, Harald; Buelow, Gerd; Lange, Udo E. W.; Mack, Helmut; Pfeiffer, Thomas; Schaefer, Bernd; Seitz, Werner; Zierke, Thomas
[Synthesis, 2004, # 14, p. 2367 - 2375]