Alternatived Products of [ 65847-73-6 ]
Product Details of [ 65847-73-6 ]
CAS No. : | 65847-73-6 |
MDL No. : | MFCD11110205 |
Formula : |
C10H9NO2
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
175.18
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 65847-73-6 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 65847-73-6 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 65847-73-6 ]
- 1
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[ 41717-32-2 ]
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[ 65847-73-6 ]
- 2
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[ 5661-50-7 ]
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[ 181934-30-5 ]
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[ 65847-73-6 ]
Yield | Reaction Conditions | Operation in experiment |
94% |
With tetrabutyl ammonium fluoride In 1,2-dichloro-ethane at -30℃; for 1h; |
|
92% |
With tetrabutyl ammonium fluoride In tetrahydrofuran at -30℃; for 2h; |
1 Example 1Preparation of 2-aminobenzofuran compound 3a
Add N-phenoxyacetamide 1a (0.2 mmol, 30.2 mg) to a 25 ml tube.2 (0.26 mmol, 111.3 mg)And tetrabutylammonium fluoride (0.26 mmol, 67.8 mg).Add tetrahydrofuran (2 mL),The mixture was stirred at a low temperature of -30 ° C for 2 hours.After completion of the reaction, the solvent was removed using a rotary evaporator to give a crude product. The crude product was purified by column chromatography (200-300 mesh silica gel) ( petroleum ether/ethyl acetate = 4/1), and the solvent was removed using a rotary evaporator.The product 2-aminobenzofuran compound 3a was obtained in a yield of 92%. |
Reference:
[1]Li, Ming; Wang, Jia-Hui; Li, Wei; Lin, Cheng-Dong; Zhang, Lin-Bao; Wen, Li-Rong
[Journal of Organic Chemistry, 2019, vol. 84, # 13, p. 8523 - 8530]
[2]Current Patent Assignee: QINGDAO UNIVERSITY OF SCIENCE AND TECHNOLOGY - CN109851599, 2019, A
Location in patent: Paragraph 0022-0025