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[ CAS No. 65996-07-8 ] {[proInfo.proName]}

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Chemical Structure| 65996-07-8
Chemical Structure| 65996-07-8
Structure of 65996-07-8 * Storage: {[proInfo.prStorage]}
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Product Details of [ 65996-07-8 ]

CAS No. :65996-07-8 MDL No. :MFCD13189139
Formula : C7H6BrNO2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :216.03 Pubchem ID :-
Synonyms :

Safety of [ 65996-07-8 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 65996-07-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 65996-07-8 ]

[ 65996-07-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 65996-17-0 ]
  • [ 65996-07-8 ]
YieldReaction ConditionsOperation in experiment
Stage #1: ethyl 2-bromo-4-methylnicotinic acid With water; sodium hydroxide In 1,4-dioxane for 12h; Reflux; Stage #2: With hydrogenchloride In water ii.D General procedure: To a solution of 4-substituted ethyl 2-bromolnicotinate (D-4) (52 mmol) in 1,4-dioxane (15 mL), a solution of NaOH (8.0 g, 200 mmol) in H20 (15 mL) is added and the resulting mixture is stirred at reflux for 12 h. The mixture is allowed to cool to RT, diluted with H20, and washed with ethyl acetate (3 x 30 mL). The aqueous layer is acidified with concentrated hydrochloric acid to adjust the pH to 1, and then extracted with ethyl acetate (3 x 50 mL). The combined organic layers are washed with brine (25 mL), dried over Na2S04 and filtered. The filtrate is concentrated in vacuo to afford the product nicotinic acid (D-5).
With water; sodium hydroxide In 1,4-dioxane for 12h; Reflux; 42 Method H; Example 42 To a solution of 4 -substituted ethyl 2-bromolnicotinate (H-4) (52 mmol) in 1,4-dioxane (15 mL), a solution of NaOH (8.0 g, 200 mmol) in H20 (15 mL) is added and the resulting mixture is stirred at reflux for 12 h. The mixture is allowed to cool to RT, diluted with H20, and washed with ethyl acetate (3 x 30 mL). The aqueous layer is acidified with concentrated hydrochloric acid to adjust the pH to 1, and then extracted with ethyl acetate (3 x 50 mL). The combined organic layers are washed with brine (25 mL), dried over Na2S04 and filtered. The filtrate is concentrated in vacuo to afford the product nicotinic acid (H-5).
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