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[ CAS No. 66346-88-1 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 66346-88-1
Chemical Structure| 66346-88-1
Structure of 66346-88-1 * Storage: {[proInfo.prStorage]}
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Product Details of [ 66346-88-1 ]

CAS No. :66346-88-1 MDL No. :MFCD24551851
Formula : C7H8ClN3O Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 185.61 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 66346-88-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 66346-88-1 ]

[ 66346-88-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 19064-64-3 ]
  • [ 66346-87-0 ]
  • [ 64068-00-4 ]
  • [ 66346-88-1 ]
YieldReaction ConditionsOperation in experiment
With ammonium hydroxide; acetic anhydride; In water; B-4. 3-Acetamido-6-chloro-5-methylpyridazine A mixture containing 117 g. of 3,6-dichloro-4-methylpyridazine, 1.2 liters of ammonium hydroxide was heated in an autoclave at 120 C. for 6 hours. The reaction mixture was allowed to cool and the separated solid was collected, washed with water and dried. The mother liquor was heated in vacuo and the remaining solid was slurried up in cold water. The solid was collected, washed with cold water and dried. The two solid materials were combined and dried in a vacuum oven at 80 C. overnight (about fifteen hours). The combined dried solids (a mixture of <strong>[66346-87-0]3-amino-6-chloro-5-methylpyridazine</strong> and 3-amino-6-chloro-4-methylpyridazine) were refluxed with 350 ml. of acetic anhydride for two hours and then allowed to stand at room temperature for about fifteen hours. The separated solid was collected by filtration and washed with ether and dried to yield, as an off-white solid, 24 g. of one isomer, namely, 3-acetamido-6-chloro-5-methylpyridazine, m.p. 214-217 C. The mother liquor from the original filtration was concentrated and treated with about 200 ml. of ether. The resulting solid was collected, washed with ether and dried, followed by recrystallization from ethyl acetate, washing with ether and dried to yield another 14 g. of 3-acetamido-6-chloro-5-methylpyridazine, m.p. 212-216 C.
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