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[ CAS No. 66621-86-1 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 66621-86-1
Chemical Structure| 66621-86-1
Structure of 66621-86-1 * Storage: {[proInfo.prStorage]}
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Product Details of [ 66621-86-1 ]

CAS No. :66621-86-1 MDL No. :
Formula : C8H10N2O4 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 198.18 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 66621-86-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 66621-86-1 ]

[ 66621-86-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 109-72-8 ]
  • [ 13566-48-8 ]
  • [ 108-18-9 ]
  • [ 66621-86-1 ]
YieldReaction ConditionsOperation in experiment
In tetrahydrofuran; water; pentane; (a) (4,6-dimethoxypyrimidin-2-yl)acetic acid n-Butyllithium (200 ml of 2N in pentane) was added dropwise over 30 minutes to a stirred solution of di-isopropylamine (40.4 g) in tetrahydrofuran (200 ml) at -70 C. under nitrogen. The mixture was stirred for 20 minutes and then <strong>[13566-48-8]4,6-dimethoxy-2-methylpyrimidine</strong> (61.6 g) in tetrahydrofuran (200 ml) was added dropwise over 20 minutes. The mixture was stirred at -70 C. for 30 minutes before being poured onto a large excess of solid carbon dioxide. The mixture was allowed to warm to room temperature before water (800 ml) was added. The clear solution was concentrated to half volume under vacuum and was then washed with ether. The aqueous phase was acidified with concentrated hydrochloric acid and the resulting solid was filtered, washed with water and dried to give 58.3 g of (4,6-dimethoxypyrimidin-2-yl)acetic acid.
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