Alternatived Products of [ 66937-93-7 ]
Product Details of [ 66937-93-7 ]
CAS No. : | 66937-93-7 |
MDL No. : | |
Formula : |
C9H17NO2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
171.24
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 66937-93-7 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 66937-93-7 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 66937-93-7 ]
- 1
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[ 4021-08-3 ]
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[ 71-41-0 ]
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[ 66937-93-7 ]
- 2
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[ 123387-50-8 ]
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[ 66937-93-7 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: 60 percent Turnov. / sec-BuLi; TMEDA / diethyl ether / 5 h / -90 - 20 °C
2: 100 percent / HCl / ethyl acetate |
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- 3
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[ 66937-93-7 ]
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[ 2743-38-6 ]
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ethyl (2R,4S)-4-methyl-2-piperidinecarboxylate L-(-)-dibenzoyl tartrate
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
46.3% |
With 1-butylpyridinium bromide; In isopropyl alcohol; acetonitrile; at 65℃; |
8.55 g of ethyl 4-methyl-2-piperidinecarboxylate racemate and 17.9 g of L-(-)-dibenzoyltartaric acid were addedStir in 125 mL of isopropanol and 50 mL of acetonitrile. Add 2.16g1-butyl bromide pyridine, heating at 65 C,After the reaction is completed, cool to room temperature.0.437 g of L-(-)-dibenzoyltartaric acid pyridinium salt was added, and the mixture was allowed to stand for 12 hours, and filtered.12.25 g of white crystals were obtained in a yield of 46.3%. |
- 4
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[ 66937-93-7 ]
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[ 147-71-7 ]
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(2S,4S)-4-methyl-2-piperidine carboxylic acid ethyl ester D-tartaric acid salt
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
47.6% |
With 1-butylpyridinium bromide In isopropyl alcohol; acetonitrile at 65℃; |
1; 2 A method for separating argatroban isomer impurities, the method comprising the steps of: S1: Preparation of ethyl (2S,4S)-4-methyl-2-piperidinecarboxylate-D-tartrate (Compound I)
crafting process: 8.55 g of ethyl 4-methyl-2-piperidinecarboxylate racemate and 7.5 g of D-tartaric acid, 150 mL of isopropanol and 100 mL of acetonitrile were added and stirred. 2.16 g of 1-butylbromide pyridine was added thereto, and the reaction was heated at 65 °C. After completion of the reaction, the mixture was cooled to room temperature. 0.229g pyridine was added D-tartrate salt, crystallization was allowed to stand 12h, Filtration gave 7.64 g of white crystals in a yield of 47.6%. |