Alternatived Products of [ 7057-46-7 ]
Product Details of [ 7057-46-7 ]
CAS No. : | 7057-46-7 |
MDL No. : | |
Formula : |
C26H23F3N2O7
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
532.47
|
Pubchem ID : | - |
Synonyms : |
|
Application In Synthesis of [ 7057-46-7 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 7057-46-7 ]
- 1
-
[ 13222-85-0 ]
-
[ 70-00-8 ]
-
[ 7057-46-7 ]
- 2
-
[ 4330-21-6 ]
-
[ 54-20-6 ]
-
[ 7057-46-7 ]
Yield | Reaction Conditions | Operation in experiment |
175 g |
|
Step-e): A mixture of trifluoro methyl uracil (139 g), hexamethyldisilazane (374.4 g) and trimethyl silyl chloride (4.21 g) was heated to 120-125C and stined for 3 hours at the same temperature. Cooled the reaction mixture to 55-60C and distilled off the reaction mixture under reduced pressure. To this reaction mixture dichloromethane (1050 ml), zinc chloride (5.28 g) and followed by (2R, 3S, SR)-5-chloro-2-(((4-methylbenzoyl)oxy)methyl) tetrahydrofuran-3-yl 4-methyl benzoate compound of formula-Ca obtained in step-d) were added at 25-30C and stined the reaction mixture for 3 hours at the same temperature. Cooled the reaction mixture to 10-15C and slowly added the aqueous sodium bicarbonate solution. Raised the temperature of the reaction mixture to 25-30C and stined for 30 minutes at the same temperature. Filtered the reaction mixture through the hyflow bed and washed with dichloromethane. Separated the both organic and aqueous layer and the aqueous layer was extracted with dichloromethane. Combined the organic layers and washed with water. Distilled off the solvent completely from the organic layer under reduced pressure and co-distilled with methanol. Methanol (600 ml) was added to the obtained compound at 25- 30C. Heated the reaction mixture to 40-45C and stined for 40 minutes at the same temperature. Filtered the solid, washed with methanol and dried to get the title compound.Yield: 175 g, purity by HPLC: 98.66%, undesired isomer: 98.66%. |
- 3
-
[ 7057-46-7 ]
-
[ 70-00-8 ]
Yield | Reaction Conditions | Operation in experiment |
39 g |
With methanol; sodium methylate; at 10 - 15℃; for 1.5h; |
Thymidine, ci,ci,ci-trifluoro-, 3,5-bis(4-methylbenzoate) (100 g) was added to the pre-cooled mixture of sodium methoxide (72.43 ml) and methanol (500 ml) at 10-15C and stined for 90 minutes at the same temperature. Cooled the reaction mixture to 0-5C and neutralized the reaction mixture using Methanolic HC1. Raised the temperature of the reaction mixture to 25- 300 C and filtered reaction mixture. Distilled off the solvent completely from the filtrate under reduced pressure and co-distilled with toluene. Toluene (300 ml) was added to the obtained compound at 25-30C and stined for 20 minutes. Filtered the solid and washed with toluene. Acetone (300 ml) was added to the obtained compound and stined for 20 minutes.Filtered the mixture and washed with acetone. Distilled off the solvent completely from the filtrate and co-distilled with methanol. Methanol (150 ml) was added to the obtained compound at 25-30C and heated to the mixture to 65-70C for 15 minutes. Cooled the mixture to 55-60C and toluene (800 ml) was added to it. Further cooling the mixture to 25- 30C and stirred for 3 hours at the same temperature. Filtered the precipitated solid, washed with toluene and dried to get the title compound.Yield: 39 gms. |