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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
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Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 7582-40-3 Chemical Structure| 7582-40-3

Structure of 7582-40-3

Chemical Structure| 7582-40-3

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Product Citations

Product Citations

Wiltsie, Vanessa E ;

Abstract: Antimicrobial resistance (AMR) is a pressing issue facing modern medicine today. Bacteria are developing resistance to antibiotics faster than new antibiotics can be brought to market. Antimicrobial resistant infections are responsible for increased morbidity and mortality rates, as well as an economic burden with increased duration of care and costs of treatments. The development of new antibiotics to combat bacterial resistance is a long and costly process and has resulted in pharmaceutical companies turning away from the traditional drug development pipeline. One alternative method to address AMR is through repurposing existing approved drugs such as by utilizing combination drug therapies. Combination drug therapies often involve the inhibition of antibiotic modifying enzymes found within bacteria. This research aims to use combination therapy to restore the functionality of the drug fosfomycin by using in silico high-throughput virtual screening (HTVS) to identify inhibitors of fosfomycin resistance enzymes. The purpose of this work is to characterize fosfomycin resistance enzymes and identify enzymatic inhibitors to restore the functionality of fosfomycin. First, we identified and characterized the fosfomycin resistance enzyme in Enterococcus faecium (FosBEf). Our goal was to structurally characterize the bacillithiol binding site, however we discovered FosBEf is unique among the FosB enzyme family and utilizes L-cys as the preferred thiol substrate and produced limited enzymatic activity with BSH. Next, we focused on identifying and characterizing inhibitors of the fosfomycin resistance protein in Pseudomonas aeruginosa (FosAPa). Initially we compared the structural and kinetic properties of established inhibitors of other classes of fosfoymcin resistance enzymes on FosA. Then we utilized in silico high-throughput virtual screening (HTVS) to identify halogenated inhibitors to modify the absorption, distribution, metabolism, and excretion properties and potential permeability into P. aeruginosa. Taken together, the findings of this work provide a scaffold for future structure-based drug design for restoring fosfomycin activity.

Keywords: Antimicrobial resistance ; crystallography ; fosfomycin ; glutathione

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Alternative Products

Product Details of [ 7582-40-3 ]

CAS No. :7582-40-3
Formula : CH4BrO3P
M.W : 174.92
SMILES Code : BrCP(O)(O)=O
MDL No. :MFCD20623854

Safety of [ 7582-40-3 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H311-H332-H314
Precautionary Statements:P260-P264-P270-P271-P280-P301+P330+P331-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P310-P405-P501
Class:8(6.1)
UN#:2923
Packing Group:
 

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