Alternatived Products of [ 800401-88-1 ]
Product Details of [ 800401-88-1 ]
CAS No. : | 800401-88-1 |
MDL No. : | |
Formula : |
C9H5N3O2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
187.16
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 800401-88-1 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 800401-88-1 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 800401-88-1 ]
- 1
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[ 800401-88-1 ]
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[ 1534-90-3 ]
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2-[(5-cyano-1H-pyrrolo[2,3-c]pyridine-2-carbony)amino]-3-(S)-(4-fluorophenyl)propionic acid ethyl ester
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 20℃; for 16.0h; |
To a solution OF 2-AMINO-3- (S)- (4-FLUOROPHENYL) propionic acid ethyl ester hydrochloride (0.530g, 2. 14MMOL) in DMF (15mL) was added DIPEA (1. 3mL, 7. 49MMOL), HOBt (0.290g, 2. 14MMOL), 5-cyano-lH-pyrrolo [2,3-c] pyridine-2- carboxylic acid (Preparation 62,0. 400g, 2. 14MMOL) and EDCI (0.492g, 2.57mmol). The reaction mixture was stirred at rt for 16H. Reaction mixture was concentrated in vacuo and the residue was partitioned between water (150ML) and ethyl acetate (200mL). Organic phase was separated and the aqueous phase was further extracted with ethyl acetate (200mL). The combined organic extracts were washed with saturated NAHC03 (75mL), saturated sodium chloride (LOOML), dried (MGS04), filtered and concentrated in vacuo to give the title compound. m/z (ES+) = 381 [M+ H] + ; RT = 4. 79MIN. |
- 2
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[ 800401-70-1 ]
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[ 800401-88-1 ]
- 3
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[ 21901-41-7 ]
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[ 800401-88-1 ]
- 4
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[ 23056-47-5 ]
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[ 800401-88-1 ]