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[ CAS No. 80441-57-2 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 80441-57-2
Chemical Structure| 80441-57-2
Structure of 80441-57-2 * Storage: {[proInfo.prStorage]}
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Product Details of [ 80441-57-2 ]

CAS No. :80441-57-2 MDL No. :MFCD03427073
Formula : C8H14O2S Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 174.26 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 80441-57-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 80441-57-2 ]

[ 80441-57-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 39160-70-8 ]
  • [ 80441-57-2 ]
  • thioacetic acid <i>S</i>-(5-{2-[2-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethylcarbamoyl}-pentyl) ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
85% With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 20℃; for 12h;
  • 2
  • [ 80441-57-2 ]
  • [ 152548-66-8 ]
  • [ 1599485-76-3 ]
YieldReaction ConditionsOperation in experiment
53% 2-Chiorotrityichioride resin (1.4 mmol/g, 357 mg, 0.5 mmol) was weighted into a 10 mL syringe with fit. The resin was swollen twice with 2 mL DCM. N-Fmoc-N-methyl-L5 aspartate(OtBu)-OH (532 mg, 1.25 mmol and DIPEA (305 jiL, 1.75 mmol) were dissolved inDCM (3 mL) and drawn into the syringe. The syringe was agitated for lh. MeOH (0.5 mL) was drawn into the syringe and the syringe agitated for 30 mm. The resin was washed 5 times with DCM (4 mL) and 5 times with DMF (4 mL). The resin was agitated 3 times for 5 mm with DMF:DBU:piperidine (96:2:2 v/v/v, 4 mL). The resin was washed 5 times with DMF (4mL). 6-tritylmercaptohexanoic acid (488 mg, 1.25 mmol) and HATU (475 mg, 1.25 mmol) were dissolved in DMF (3 mL) and DIPEA (436 .iL, 2.5 mmol) added. After 1 mm preincubation the solution was drawn into the syringe and the syringe agitated for 1 h. The resin was washed 5 times with DMF (4 mL), 5 times with DCM (4 mL) and twice with MeOH (4 mL) and dried in vacuo. A solution of HFIP/TES/acetic acid (90/5/5 v/v/v, 3 mLeach) were drawn into the syringe and the syringe agitated twice for 30 mm. The solvent of the collected filtrates was evaporated in a stream of nitrogen. The residue was suspended in ACN/water (1:1 v/v, 5 mL) and filtered off. 2,2?-dithiodipyridine (220 mg, 1 mmol) in ACN (0.5 mL) was added to the filtrate. pH of the reaction was adjusted to 7 with pH 7.4 sodium phosphate buffer (0.5 M, 1.2 mL) and stirred for 15 mm. The product was directly purifiedby RP-HPLC to give ha (117 mg, 0.27 mmol, 53%) MS: m/z 443.30= [M+H], (calculated =443.17).
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