[ CAS No. 848498-20-4 ] {[proInfo.proName]}

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• [ 848498-20-4 ]
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• [ 72985-23-0 ]

Yield	Reaction Conditions	Operation in experiment
29.9%	With calcium carbonate In 1,4-dioxane; water for 5 h; Reflux	6. 6-Methylisobenzofuran- 1 (3H)-one; A heterogeneous, colorless solution of methyl 2-(bromomethyl)-5- methylbenzoate and regioisomer (27.2 mmol) and calcium carbonate (16.33 g, 163 mmol) in 1,4-dioxane (194 mL) and water (194 mL) was refluxed. After 5 hr, the reaction was cooled to room temperature. The insolubles were filtered, and the filtrate wasconcentrated in vacuo. The residue was extracted with CH2CL2 (2 x 200 mL). The organic layers were combined, dried over MgSO4, and concentrated in vacuo to give an oil which was purified by flash chromatography using an ISCO 220g column eluting with 10-50percent EtOAc/hexanes. Appropriate fractions were collected and concentrated in vacuo to give the desired product (1.205 g, 8.13 mmol, 29.9percent yield) as a white solid.