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CAS No. : | 870970-82-4 | MDL No. : | MFCD22690436 |
Formula : | C6H13ClN2O | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 164.63 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Class: | ||
Precautionary Statements: | UN#: | ||
Hazard Statements: | Packing Group: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With hydrogenchloride; In 1,4-dioxane; at 20.0℃; for 4.0h; | Step C. (2R)-Piperidine-2-carboxamide; tert-Butyl (2R)-2-(aminocarbonyl)piperidine-1-carboxylate (2.28 g, 10 mmol) was treated with 4 NHCI in dioxane (60 mL, 240 mmol) for 4 h at room temperature. After evaporation of the solvent, the title compound was washed with ether and dried in vacuo (HCl salt, 1.65 g, 100 %). 1H NMR (400 MHz, DMSO-D6) No. 1.36 1.81 (m, 5 H), 2.11 (m, 1 H), 2.77 - 2.97 (m, 1 H), 3.16 (m, 1 H), 3.67 (m, 1 H), 7.54 (s, 1 H), 7.94 (s, 1 H), 8.61 (s, 1 H), 9.22 (s, 1 H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | Step D. [(2R)-Piperidin-2-ylmethyl]amine; (2R) -piperidine-2-carboxamide (HCI salt, 1.65 g, 10 mmol) was treated with LAH (2.2 g, 58 mmol) in THF (150 mL) for 18 h at room temperature and 3 h at reflux. The mixture was cooled down, quenched with MeOH (10 mL) and H20 (10 mL). Na2S04 (100 g) was added. The resulting mixture was stirred for 2h at room temperature. After filtration and evaporation of the solvent (1.14 g, 100 %) of the title compound was obtained as a crude product, which was directly used for next step. |