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Chemical Structure| 877132-28-0 Chemical Structure| 877132-28-0

Structure of 877132-28-0

Chemical Structure| 877132-28-0

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Product Details of [ 877132-28-0 ]

CAS No. :877132-28-0
Formula : C9H10N4O3
M.W : 222.20
SMILES Code : O=C(C1=CN2C(N=C1)=NC(CO)=N2)OCC

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Application In Synthesis of [ 877132-28-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 877132-28-0 ]

[ 877132-28-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 27277-03-8 ]
  • [ 80370-42-9 ]
  • [ 877132-28-0 ]
YieldReaction ConditionsOperation in experiment
In acetic acid; at 60℃; for 18h; 5-Amino-1H-[1,2,4]triazol-3-yl)-methanol (Bru-Magniez et al US (1995) US 5387747 A19950207) (7.9g, 41.6mmol) was mixed with <strong>[80370-42-9]2-formyl-3-oxo-propionic acid ethyl ester</strong> (Torri Sigeri et al Synthesis (1986) 5 pg 400-402), (6.0g, 41.6mmol) in acetic acid (30ml). The reaction mixture was heated to 60°C for 18hrs. After which time the mixture was cooled to room temperature and diluted with diethyl ether (200ml). Product crashes out of solution. The solids are then filtered and washed with diethyl ether (200ml), product dried in vacc oven for 5 hrs. To afford title compound as a white solid (8.0g). 1H NMR (300MHz, CDCI3): 5 1.47 (t, J=6.97, Hz, 3 H) 3.00 (bs, 1 H) 4.53 (q, J=7.16 Hz, 2 H), 5.00 (s, 2 H) 9.40 (d, J=2.07, Hz, 1 H) 9.50 (d, J=2.07, Hz, 1 H)
 

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