Home Cart 0 Sign in  

[ CAS No. 884305-07-1 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 884305-07-1
Chemical Structure| 884305-07-1
Structure of 884305-07-1 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 884305-07-1 ]

Related Doc. of [ 884305-07-1 ]

Alternatived Products of [ 884305-07-1 ]

Product Details of [ 884305-07-1 ]

CAS No. :884305-07-1 MDL No. :
Formula : C21H19ClN4O2S Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 426.92 Pubchem ID :-
Synonyms :

Safety of [ 884305-07-1 ]

Signal Word: Class:
Precautionary Statements: UN#:
Hazard Statements: Packing Group:

Application In Synthesis of [ 884305-07-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 884305-07-1 ]

[ 884305-07-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 884305-06-0 ]
  • [ 87691-87-0 ]
  • [ 118289-55-7 ]
  • [ 118307-04-3 ]
  • [ 884305-08-2 ]
  • [ 884305-07-1 ]
  • [ 122883-93-6 ]
YieldReaction ConditionsOperation in experiment
With tetrabutylammomium bromide; sodium carbonate; sodium iodide; In cyclohexane;Heating / reflux; A mixture of 100 g of 5-(2-chloroethyl)-6-chlorooxindole, 95.2 g of 3-(1-piperazinyl)-1,2-benzisothiazole, 92.1 g of sodium carbonate, 6.5 g of sodium iodide, 28 g of tetrabutylammonium bromide and 1000 ml of cyclohexane was refluxed until reaction completion as shown by thin layer chromatography. The reaction mass was cooled to 30 C. and the solid was filtered. 1000 ml of water was added to the wet compound and stirred for 95 minutes. The solid was filtered and washed with 100 ml water. To the wet compound, 1000 ml methanol was added and stirred for 2.5 to 3 hours at room temperature. The compound was filtered and washed with 200 ml of methanol and dried to afford 142.6 g of the title compound.
YieldReaction ConditionsOperation in experiment
With pyrographite; In methanol; chloroform; for 0.333333h;Heating / reflux;Purification / work up; 120 g of crude ziprasidone base, 750 ml of methanol, and 2250 ml of chloroform were heated to reflux until a clear solution was obtained. 6 g of carbon was added to the resulting reaction solution and maintained at reflux temperature for 20 minutes. The carbon was removed by filtration and the filtrate was heated to distill the solvent until about 1160 ml of distillate was collected. 1200 ml of methanol was added slowly to the reaction mass and the mixture was cooled to a temperature of 30 C. and stirred at the same temperature for 1.5 to 2 hours. Then the formed solid was filtered, washed with 240 ml methanol and dried to afford 89.3 g of the title compound substantially free of the keto ziprasidone (about 80 ppm by HPLC) and hydroxy ziprasidone (about 30 ppm by HPLC) impurities.
Same Skeleton Products
Historical Records