Alternatived Products of [ 885618-54-2 ]
Product Details of [ 885618-54-2 ]
CAS No. : | 885618-54-2 |
MDL No. : | MFCD22690814 |
Formula : |
C16H22ClN5OS
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
367.90
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 885618-54-2 ]
Application In Synthesis of [ 885618-54-2 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 885618-54-2 ]
- 1
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[ 915411-02-8 ]
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[ 885618-54-2 ]
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2-(1H-indazol-4-yl)-6-(4-methylpiperazin-1-yl-methyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
81% |
With sodium carbonate In ethanol; water; toluene at 130℃; for 2h; Irradiation; |
2
Example 2: 2-(lH-IndazoI-4-yl)-6-(4-methvI-piperazin-l-ylmethyl)-4- morpholin-4-yl-thieno[3,2-dlpyrimidine (59) by Route 2 Indazole-4-boronate ester (2.0eq., 0.82mmol), 2-Chloro-6-(4-methyl- piperazin-1-yl methyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (compound 72 prepared in Reference Example 4: 150mg, 0.41mmol) and sodium carbonate (3.0eq., 130mg) were combined in a mixture of toluene (2mL), ethanol (ImL) and water (0.5mL). PdCl2(PPh3 )2 (O.leq.) was added and the reaction mixture was flushed with Argon, and then heated in a microwave reactor at 13O0C for 2 h. Following extraction EPO (DCM/brine) and flash column chromatography, the product was isolated as a white solid (149mg, 81%) |