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[ CAS No. 886500-65-8 ]

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2D
Chemical Structure| 886500-65-8
Chemical Structure| 886500-65-8
Structure of 886500-65-8 *Storage: {[proInfo.prStorage]}

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Product Details of [ 886500-65-8 ]

CAS No. :886500-65-8MDL No. :MFCD06740077
Formula : C11H12ClNO Boiling Point : -
Linear Structure Formula :-InChI Key :-
M.W :209.67Pubchem ID :-
Synonyms :

Computed Properties of [ 886500-65-8 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 886500-65-8 ]

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Application In Synthesis of [ 886500-65-8 ]

  • Downstream synthetic route of [ 886500-65-8 ]

[ 886500-65-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 123-75-1 ]
  • [ 84194-36-5 ]
  • [ 886500-65-8 ]
YieldReaction ConditionsOperation in experiment
73% With potassium carbonate; In dimethyl sulfoxide; at 100℃; A 100 mL round-bottom flask was charged with <strong>[84194-36-5]2-chloro-4-fluorobenzaldehyde</strong> (2.50 g, 15.8 mmol, 1.00 equiv), pyrrolidine (2.20 g, 30.9 mmol, 2.00 equiv), potassium carbonate (4.40 g, 31.8 mmol, 2.00 equiv), DMSO (50 mL). The resulting solution was stirred overnight at 100 °C, diluted with 0 (50 mL), extracted with ethyl acetate (3 x 30 mL). The organic layers were combined and washed with brine (100 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was chromatographed on a silica gel column with ethyl acetate/petroleum ether (20/80) to provide 2.40 g (73percent yield) of 2- chloro-4-(pyrrolidin-l-yl)benzaldehyde as a yellow solid. LCMS: (ESI, m/z): 210 [M+H] +.
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