Alternatived Products of [ 886501-07-1 ]
Product Details of [ 886501-07-1 ]
CAS No. : | 886501-07-1 |
MDL No. : | MFCD07782178 |
Formula : |
C13H11F3N2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
252.24
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 886501-07-1 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 886501-07-1 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 886501-07-1 ]
- 1
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[ 886501-07-1 ]
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[ 10130-89-9 ]
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[ 1254205-45-2 ]
Yield | Reaction Conditions | Operation in experiment |
3% |
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Step-2: 4-(N-Benzyl-N-(3-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoic acid[0160] To a solution of N-benzyl-3-(trifluoromethyl)pyridin-2-amine (step- 1 of Example 2, 40 mg; 0.16 mmol) in pyridine (1 mL) was added 4-(chlorosulfonyl)benzoic acid (350 mg, 1.6 mmol) at room temperature. The reaction mixture was stirred at 80 0C for 2 hrs. After the reaction mixture was cooled to room temperature, DMAP (3.9 mg, 0.03 mmol) was added to the mixture. The reaction mixture was refluxed with stirring for 2 days. After the reaction mixture was cooled to room temperature, the reaction was quenched with sat. NaHCO3 aqueous solutions and the product was extracted with DCM. The organic layer was then washed with brine, dried over Na2SO4. After the filtration to separate solvent and Na2SO4, the solvent was removed under reduced pressure to give the residue. The residue was diluted with methanol and applied onto a strong cation exchange cartridge (BondElute (registered trademark) SCX, 1 g/6 mL, Varian Inc.), and the solid phase matrix was rinsed with MeOH (6 mL). The crude mixture was eluted in a collection tube with 1 M ammonia in MeOH (6 mL) and concentrated in vacuo. The residue was purified by preparative LC-MS (Process A) to give 2.0 mg (3% yield) of the titled compound. |
- 2
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[ 886501-07-1 ]
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[ 4463-41-6 ]
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[ 1416556-05-2 ]
Yield | Reaction Conditions | Operation in experiment |
77% |
With 3,3-dimethyl-butan-2-one; dodecacarbonyl-triangulo-triruthenium at 140℃; for 24h; Inert atmosphere; |
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- 3
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[ 886501-07-1 ]
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[ 1370412-35-3 ]
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[ 1416556-06-3 ]
Yield | Reaction Conditions | Operation in experiment |
70% |
With 3,3-dimethyl-butan-2-one; dodecacarbonyl-triangulo-triruthenium at 140℃; for 24h; Inert atmosphere; |
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- 4
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[ 886501-07-1 ]
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[ 155826-85-0 ]
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[ 1416556-07-4 ]
Yield | Reaction Conditions | Operation in experiment |
61% |
With 3,3-dimethyl-butan-2-one; dodecacarbonyl-triangulo-triruthenium at 140℃; for 24h; Inert atmosphere; |
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