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Chemistry
Organic Building Blocks
Amines
6-Chloro-N,1-dimethyl-1H-imidazo[4,5-c]pyridin-4-amine
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Organic Building Blocks
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[ CAS No. 887147-21-9 ] {[proInfo.proName]}

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Chemical Structure| 887147-21-9
Chemical Structure| 887147-21-9
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COA NMR CNMR HPLC LC-MS

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Product Details of [ 887147-21-9 ]

CAS No. :887147-21-9 MDL No. :MFCD20664376
Formula : C8H9ClN4 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 196.64 Pubchem ID :-
Synonyms :

Safety of [ 887147-21-9 ]

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Precautionary Statements: UN#:
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Application In Synthesis of [ 887147-21-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 887147-21-9 ]

[ 887147-21-9 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 887147-19-5 ]
  • [ 74-89-5 ]
  • [ 887147-21-9 ]
YieldReaction ConditionsOperation in experiment
98% In ethanol; at 110℃; for 1.5h;Microwave irradiation; A1.8: 4-Methylamino-6-chloro- 1 -methyl- 1 H-imidazo[4,5-c]pyridine; A1.8A mixture of A1.5 (0.47 g; 2.3 mmol) and 8M methylamine in ethanol (5 ml) was heated to 110 C. in a microwave apparatus for 1.5 hr. After removing the volatiles in vacuo, the residue was triturated with water, filtered and dried to afford59 EPO <DP n="61"/>0.44 g (98%) of A1.8 as a tan solid. HPLC (A): 99%, ret. time = 0.76 min., LC/MS (M+H)+ = 197.14 (199.06).
90 - 93% In ethanol; at 82 - 120℃; for 3 - 24h;Product distribution / selectivity; A mixture of A1.5 (9.9 g; 49 mmol) and methylamine (8M solution in ethanol,80mmol, 100 ml) was heated to 82 C for 24 hr. After removing the volatiles in vacuo, the residue was triturated with water (30 mL), filtered and dried to afford 8.89 EPO <DP n="76"/>g (93%) of A1.8 as a tan solid. HPLC (A): 99%, ret. time = 0.98 min., LC/MS (M+H)+ = 197.16 (199.06).Alternate preparation: A1.7 (26Og, 1.3 mol) and methylamine 40% in ethanol (3.0 L) were placed in an autoclave and heated between 110-120 0C for 3h. The reaction mixture was allowed to cool to room temperature and the solvent was removed by distillation under reduced pressure. The residue was triturated with water (15 L) and then washed with hexane (5L) and dried to yield A1.8 (228g, 90%).
Reference： [1]Patent: WO2006/53166,2006,A1 .Location in patent: Page/Page column 59-60
[2]Patent: WO2006/122137,2006,A1 .Location in patent: Page/Page column 74-75; 75
[3]Bioorganic and Medicinal Chemistry Letters,2009,vol. 19,p. 2646 - 2649
  • 2
  • [ 175461-33-3 ]
  • [ 887147-21-9 ]
Reference： [1]Patent: WO2006/122137,2006,A1
[2]Patent: WO2006/122137,2006,A1
  • 3
  • [ 887147-21-9 ]
  • [ 914942-88-4 ]
Reference： [1]Patent: WO2006/122137,2006,A1

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