Alternatived Products of [ 892664-08-3 ]
Product Details of [ 892664-08-3 ]
CAS No. : | 892664-08-3 |
MDL No. : | MFCD16036501 |
Formula : |
C9H11Cl2NO2
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
236.10
|
Pubchem ID : | - |
Synonyms : |
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Safety of [ 892664-08-3 ]
Application In Synthesis of [ 892664-08-3 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 892664-08-3 ]
- 1
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[ 41337-81-9 ]
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[ 892664-08-3 ]
Yield | Reaction Conditions | Operation in experiment |
100% |
With thionyl chloride In dichloromethane |
|
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With thionyl chloride In dichloromethane for 0.5h; |
3.1; 3.2
Ethyl 6-(chloromethyl)-2-pyridinecarboxylate hydrochloride; Reaction 1; 28.56g (0.24mol) of thionyl chloride were added over 5 minutes to a stirred solution of 36.2g (0.2mol) of ethyl 6-(hydroxymethyl)-2-pyridinecarboxylate in dichloromethane (250ml) with water bath cooling and stirred for 30 minutes. Evaporated in vacuo, and re- evaporated with 100ml toluene to give 48g of white oil, which was used immediately; Reaction 2; EPO As for Reaction 1, using 45.14g of ethyl 6-(hydroxymethyl)-2-pyridinecarboxylate and 33g thionyl chloride in 500ml dichloromethane. Yield 59.9g |
Reference:
[1]Location in patent: scheme or table
Hall, Adrian; Billinton, Andy; Brown, Susan H.; Chowdhury, Anita; Clayton, Nicholas M.; Giblin, Gerard M.P.; Gibson, Mairi; Goldsmith, Paul A.; Hurst, David N.; Naylor, Alan; Peet, Caroline F.; Scoccitti, Tiziana; Wilson, Alexander W.; Winchester, Wendy
[Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 9, p. 2599 - 2603]
[2]Current Patent Assignee: GLAXOSMITHKLINE PLC - WO2006/66968, 2006, A1
Location in patent: Page/Page column 37-38