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[ CAS No. 91374-22-0 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 91374-22-0
Chemical Structure| 91374-22-0
Structure of 91374-22-0 * Storage: {[proInfo.prStorage]}
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Product Details of [ 91374-22-0 ]

CAS No. :91374-22-0 MDL No. :MFCD07782131
Formula : C15H22N2O3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 278.35 Pubchem ID :-
Synonyms :

Safety of [ 91374-22-0 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P280-P305+P351+P338-P310 UN#:N/A
Hazard Statements:H302-H315-H319-H332-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 91374-22-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 91374-22-0 ]

[ 91374-22-0 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 23876-13-3 ]
  • [ 91374-22-0 ]
  • 3
  • [ 60468-54-4 ]
  • [ 91374-22-0 ]
  • 4
  • [ 23876-15-5 ]
  • [ 142-84-7 ]
  • [ 91374-22-0 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; thionyl chloride; sodium carbonate; In water; toluene; EXAMPLE 2 A mixture of 22.0 g (0.105 mole) of <strong>[23876-15-5]2-methyl-3-nitrophenylacetic acid</strong> and 25 cc of thionyl chloride was slowly heated to 75 and the copious evolution of gasses allowed to moderate. The temperature was raised and the solution was refluxed for 1 hour. The reaction was concentrated in vacuo. The residual straw-colored syrup was chased several times with dry toluene, diluted with 100 cc of dry toluene and added to a cool (10) mixture of 13 g of sodium carbonate in 150 cc of water and 150 cc of toluene containing 14.5 cc (10.6 g, 0.12 mole) of di-n-propylamine with very slow stirring. After 30 minutes, the ice-bath was removed. Stirring was continued for one hour. An additional 0.5 g of solid sodium carbonate was added to the reaction. After 15 minutes, the organic phase was separated, washed with 5% aqueous sodium carbonate followed by 2N hydrochloric acid and, finally, water. The organic solution was dried over magnesium sulfate, concentrated in vacuo and pumped free of solvent to give 29.5 g of 2-methyl-3-nitrophenyl-N,N-di-n-propylacetamide as a straw-colored syrup.
With hydrogenchloride; thionyl chloride; sodium carbonate; In water; toluene; EXAMPLE 2 A mixture of 22.0 g (0.105 mole) of <strong>[23876-15-5]2-methyl-3-nitrophenylacetic acid</strong> (V. Askam et al., J. Chem. Soc. (C) 1969 1935) and 25 cc of thionyl chloride was slowly heated to 75 and the copious evolution of gasses allowed to moderate. The temperature was raised and the solution was refluxed for 1 hour. The reaction was concentrated in vacuo. The residual straw-colored syrup was chased several times with dry toluene, diluted with 100 cc of dry toluene and added to a cool (10) mixture of 13 g of sodium carbonate in 150 cc of water and 150 cc of toluene containing 14.5 cc (10.6 g, 0.12 mole) of di-n-propylamine with very slow stirring. After 30 minutes, the ice-bath was removed. Stirring was continued for one hour. An additional 0.5 g of solid sodium carbonate was added to the reaction. After 15 minutes, the organic phase was separated, washed with 5% aqueous sodium carbonate followed by 2N hydrochloric acid and, finally water. The organic solution was dried over magnesium sulfate, concentrated in vacuo and pumped free of solvent to give 29.5 g of 2-methyl-3-nitrophenyl-N,N-di-n-propyl acetamide as a straw-colored syrup.
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