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Chemical Structure| 928336-97-4 Chemical Structure| 928336-97-4

Structure of 928336-97-4

Chemical Structure| 928336-97-4

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Product Details of [ 928336-97-4 ]

CAS No. :928336-97-4
Formula : C13H7ClF3N3
M.W : 297.66
SMILES Code : FC(C1=CC(C2=CN=C3C=CC(Cl)=NN32)=CC=C1)(F)F

Safety of [ 928336-97-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 928336-97-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 928336-97-4 ]

[ 928336-97-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 13526-66-4 ]
  • [ 325142-82-3 ]
  • [ 928336-97-4 ]
YieldReaction ConditionsOperation in experiment
69% With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In 1,4-dioxane; at 100℃; for 21h;Inert atmosphere; General procedure: To a solution under N2 of3-bromo-6-chloro-imidazo[1,2-b]pyridazine (1 g, 4.3 mmol) in dioxane (45 mL), Pd[P(C6H5)3]4(0.248 g, 0.2 mmol), 5-indole-5-boronic acid (0.728 g, 4.51 mmol) and Na2CO3(2 M, 7.7 mL) were added. The mixture was stirred for 21 h at 100 C. Thereaction was monitored by TLC. The solvent was evaporated under reducedpressure. The crude residue was diluted and stirred in AcOEt and ammoniumchloride solution (saturated). The product was extracted with AcOEt, and theorganic layer was washed with NaCl solution. The organic layer was dried overNa2SO4, filtered, and evaporated under reduced pressure.The crude residue was purified by chromatography on silica gel using DCM-AcOEt(6:4) afforded 6a in 72% yield(0.840 g) as a light green powder.
 

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