Home Cart 0 Sign in  

[ CAS No. 94205-62-6 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 94205-62-6
Chemical Structure| 94205-62-6
Structure of 94205-62-6 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 94205-62-6 ]

Related Doc. of [ 94205-62-6 ]

Alternatived Products of [ 94205-62-6 ]

Product Details of [ 94205-62-6 ]

CAS No. :94205-62-6 MDL No. :MFCD00178260
Formula : C16H12N2O2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 264.28 Pubchem ID :-
Synonyms :

Safety of [ 94205-62-6 ]

Signal Word: Class:
Precautionary Statements: UN#:
Hazard Statements: Packing Group:

Application In Synthesis of [ 94205-62-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 94205-62-6 ]

[ 94205-62-6 ] Synthesis Path-Downstream   1~64

  • 1
  • [ 302-17-0 ]
  • [ 94205-62-6 ]
  • 2-[4-(2-hydroxyimino-acetylamino)-phenyl]-quinoline-4-carboxylic acid [ No CAS ]
  • 2
  • [ 94205-62-6 ]
  • [ 108-24-7 ]
  • 2-(4-acetamidophenyl)quinoline-4-carboxylic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
69% With triethylamine; In dichloromethane; at 0 - 20℃; for 2h; Step B: 2-(4-Acetamidophenyl)quinoline-4-carboxylic acid (3) [00364] To a solution of <strong>[94205-62-6]2-(4-aminophenyl)quinoline-4-carboxylic acid</strong> (1.0 g, 3.79 mmol) in DCM (20 mL) was added acetic anhydride (773 mg, 7.6 mmol), Et3N(l.15 g, 11.37 mmol) at 0C and the reaction mixture was stirred at room temperature for 2 h. The reaction mixture was quenched with water (100 ml) and extracted with DCM (50 mL x 2). The combined organic layers were concentrated and purified by silica gel column chromatography with ethyl acetate to give the product (800 mg, 69%) as a yellow solid. LC-MS: (M + H)+ 307.1
  • 3
  • [ 94205-62-6 ]
  • [ 22191-97-5 ]
  • 4
  • [ 91-56-5 ]
  • [ 99-92-3 ]
  • [ 94205-62-6 ]
YieldReaction ConditionsOperation in experiment
99% With water; potassium hydroxide; In ethanol; at 100℃; [00442] A solution of 1 -(4-aminophenyl)ethan- 1 -one (27.5 g, 104 mmol) in EtOH (200 mL) was added to a solution of indoline-2,3-dione (20 g, 148 mmol) in 6 M aqueous KOH (200 mL) at 100C. The reaction was monitored by LC-MS until the starting material was consumed. Then the reaction mixture was concentrated to remove EtOH. The residue was diluted with water. The pH value of the mixture was acidified to 5 by adding 1M aqueous HC1 solution. The precipitate was filtered to give the desired product (28 g, 99%) as red solid.
  • 5
  • 2-<4-nitro-phenyl>-cinchoninic acid [ No CAS ]
  • [ 94205-62-6 ]
  • 6
  • [ 94205-62-6 ]
  • [ 89-25-8 ]
  • 2-{4-[<i>N</i>'-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-pyrazol-4-ylidene)-hydrazino]-phenyl}-quinoline-4-carboxylic acid [ No CAS ]
  • 7
  • [ 94205-62-6 ]
  • [ 86-92-0 ]
  • 2-{4-[<i>N</i>'-(3-methyl-5-oxo-1-<i>p</i>-tolyl-1,5-dihydro-pyrazol-4-ylidene)-hydrazino]-phenyl}-quinoline-4-carboxylic acid [ No CAS ]
  • 8
  • [ 94205-62-6 ]
  • [ 89-36-1 ]
  • 2-(4-{<i>N</i>'-[3-methyl-5-oxo-1-(4-sulfo-phenyl)-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-phenyl)-quinoline-4-carboxylic acid [ No CAS ]
  • 9
  • [ 94205-62-6 ]
  • [ 121-69-7 ]
  • 4-(4-hydroxycarbonyl-2-quinolyl)-4'-(dimethylamino)azobenzene [ No CAS ]
  • 10
  • [ 94205-62-6 ]
  • [ 120-71-8 ]
  • 4-(4-hydroxycarbonyl-2-quinolyl)-4'-amino-2'-methyl-5'-methoxyazobenzene [ No CAS ]
  • 11
  • [ 94205-62-6 ]
  • [ 135-19-3 ]
  • 4-(4-hydroxycarbonyl-2-quinolyl)(2-hydroxy-1-naphthylazo)benzene [ No CAS ]
  • 12
  • [ 94205-62-6 ]
  • [ 108-95-2 ]
  • 4-(4-hydroxycarbonyl-2-quinolyl)-4'-hydroxyazobenzene [ No CAS ]
  • 13
  • [ 302-17-0 ]
  • [ 94205-62-6 ]
  • [ 725705-08-8 ]
  • 14
  • [ 94205-62-6 ]
  • [ 607-97-6 ]
  • 2-{4-[<i>N</i>'-(1-ethyl-2-oxo-propylidene)-hydrazino]-phenyl}-quinoline-4-carboxylic acid [ No CAS ]
  • 15
  • [ 94205-62-6 ]
  • [ 607-97-6 ]
  • 2-{4-[<i>N</i>'-(1-ethoxycarbonyl-propylidene)-hydrazino]-phenyl}-quinoline-4-carboxylic acid [ No CAS ]
  • 16
  • [ 94205-62-6 ]
  • [ 864857-50-1 ]
  • 17
  • [ 94205-62-6 ]
  • 2-(2-acetyl-3-methyl-1<i>H</i>-indol-5-yl)-quinoline-4-carboxylic acid [ No CAS ]
  • 18
  • [ 94205-62-6 ]
  • 2-(2-ethoxycarbonyl-3-methyl-1<i>H</i>-indol-5-yl)-quinoline-4-carboxylic acid [ No CAS ]
  • 19
  • [ 94205-62-6 ]
  • 2',3'-dimethyl-[2,6']biquinolinyl-4,4'-dicarboxylic acid [ No CAS ]
  • 20
  • [ 94205-62-6 ]
  • formic acid-(4-[2]quinolyl-anilide) [ No CAS ]
  • 21
  • [ 94205-62-6 ]
  • 2-(4-acetamidophenyl)quinoline [ No CAS ]
  • 22
  • [ 94205-62-6 ]
  • (4-[2]quinolyl-phenyl)-urea [ No CAS ]
  • 23
  • [ 94205-62-6 ]
  • (4-[2]quinolyl-phenyl)-thiourea [ No CAS ]
  • 24
  • [ 94205-62-6 ]
  • (4-[2]quinolyl-phenyl)-selenourea [ No CAS ]
  • 25
  • [ 94205-62-6 ]
  • <i>N</i>-benzylidene-4-[2]quinolyl-aniline [ No CAS ]
  • 26
  • [ 94205-62-6 ]
  • 4-[2]quinolyl-<i>N</i>-(4-methyl-benzyliden)-aniline [ No CAS ]
  • 27
  • [ 94205-62-6 ]
  • <i>N</i>-benzyl-4-[2]quinolyl-aniline [ No CAS ]
  • 28
  • [ 94205-62-6 ]
  • 4-[2]quinolyl-<i>N</i>-(4-methoxy-benzyliden)-aniline [ No CAS ]
  • 29
  • [ 94205-62-6 ]
  • <i>N</i>-(4-[2]quinolyl-phenyl)-diacetamide [ No CAS ]
  • 30
  • [ 94205-62-6 ]
  • benzoic acid-(4-[2]quinolyl-anilide) [ No CAS ]
  • 31
  • [ 94205-62-6 ]
  • <i>N</i>,<i>N</i>'-bis-(4-[2]quinolyl-phenyl)-methylenediamine [ No CAS ]
  • 32
  • [ 94205-62-6 ]
  • <i>N</i>,<i>N</i>'-bis-(4-[2]quinolyl-phenyl)-thiourea [ No CAS ]
  • 33
  • [ 94205-62-6 ]
  • 4-(1,2,3,4-tetrahydro-[2]quinolyl)-aniline [ No CAS ]
  • 34
  • [ 94205-62-6 ]
  • <i>N</i>-(4-[2]quinolyl-phenyl)-phthalimide [ No CAS ]
  • 35
  • [ 38256-93-8 ]
  • [ 94205-62-6 ]
  • 2-(4-aminophenyl)-N-(2-methoxyethyl)-N-methylquinoline-4-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20℃; for 16h; [00462] A mixture of <strong>[94205-62-6]2-(4-aminophenyl)quinoline-4-carboxylic acid</strong> (2 g, 7.6 mmol, prepared in part A), 2-methoxy-N-methylethan-l -amine (1.02 g, 11.4 mmol), HOBT (2.05 g, 15.2 mmol), EDCI (2.91 g, 15.2 mmol) and DIEA (2.95 g, 22.8 mmol) in DCM (30 mL) was stirred at rt for 16h. Water was added to the reaction mixture and extracted with EA. The combined organic phase was dried over anhydrous sodium sulfate, and the solvent was concentrated to give crude title product (white solid 1.33 g, 52%).
  • 36
  • [ 110-91-8 ]
  • [ 94205-62-6 ]
  • (2-(4-aminophenyl)quinolin-4-yl)(morpholino)methanone [ No CAS ]
YieldReaction ConditionsOperation in experiment
63% With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20℃; for 16h; Step A: (2-(4-Aminophenyl)quinolin-4-yl)(morpholino)methanone (34) [00402] A mixture of <strong>[94205-62-6]2-(4-aminophenyl)quinoline-4-carboxylic acid</strong> (2, Example 1, step A) (1.0 g, 3.8 mmol), morpholine (496 mg, 5.7 mmol), HOBt (1.03 g, 7.6 mmol), EDCI (1.45g, 7.6 mmol) and DIPEA (1.47g, 11.4 mmol) in DCM(30 mL) was stirred at room temperature for 16h. Water (50 mL) was added to the reaction mixture and extracted with EA (50 mL x 3). The combined organic layers were concentrated and purified by silica gel column chromatography with ethyl acetate to give the product (800 mg, 63%) as a white solid. LC-MS: (M + H)+ 334.2
  • 37
  • [ 94205-62-6 ]
  • [ 75-36-5 ]
  • 2-(4-acetamidophenyl)quinoline-4-carboxylic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0℃; [00443] A solution of <strong>[94205-62-6]2-(4-aminophenyl)quinoline-4-carboxylic acid</strong> (10 g, 37.9 mmol) in THF was stirred at 0C. Then DIPEA (7.65 g, 59.3 mmol) was added. After that acetyl chloride (3.56 g, 45.6 mmol) was added to the reaction mixture until the starting material was consumed. The reaction mixture was quenched with ice water and extracted with EA, and combined organic phase was dried over anhydrous sodium sulfate. The solvent was concentrated to give crude title product (yellow solid 7.3 g, 63%).
  • 38
  • [ 94205-62-6 ]
  • 2-(2-(4-aminophenyl)quinolin-4-yl)-1-morpholinoethanone [ No CAS ]
  • 39
  • [ 94205-62-6 ]
  • 4-(4-(2-morpholinoethyl)quinolin-2-yl)benzenamine [ No CAS ]
  • 40
  • [ 94205-62-6 ]
  • N-(4-(4-(2-morpholinoethyl)quinolin-2-yl)phenyl)acetamide [ No CAS ]
  • 41
  • [ 94205-62-6 ]
  • N-(4-(4-(2-morpholino-2-oxoethyl)quinolin-2-yl)phenyl)acetamide [ No CAS ]
  • 42
  • [ 94205-62-6 ]
  • methyl 2-(4-acetamidophenyl)quinoline-4-carboxylate [ No CAS ]
  • 43
  • [ 94205-62-6 ]
  • 2-(4-acetamidophenyl)quinoline-4-carboxylic (isobutyl carbonic) anhydride [ No CAS ]
  • 44
  • [ 94205-62-6 ]
  • N-(4-(4-(hydroxymethyl)quinolin-2-yl)phenyl)acetamide [ No CAS ]
  • 45
  • [ 94205-62-6 ]
  • N-(4-(4-formylquinolin-2-yl)phenyl)acetamide [ No CAS ]
  • 46
  • [ 94205-62-6 ]
  • 2-(4-acetamidophenyl)-N-(2-(dimethylamino)ethyl)quinoline-4-carboxamide [ No CAS ]
  • 47
  • [ 94205-62-6 ]
  • N-(4-(4-((butylamino)methyl)quinolin-2-yl)phenyl)acetamide [ No CAS ]
  • 48
  • [ 94205-62-6 ]
  • N-(4-(4-(chloromethyl)quinolin-2-yl)phenyl)acetamide [ No CAS ]
  • 49
  • [ 94205-62-6 ]
  • N-(4-(4-((methyl(2-(methylamino)ethyl)amino)methyl)quinolin-2-yl)phenyl)acetamide [ No CAS ]
  • 50
  • [ 94205-62-6 ]
  • N-(4-(4-(((2-methoxyethyl)(methyl)amino)methyl)quinolin-2-yl)phenyl)acetamide [ No CAS ]
  • 51
  • [ 94205-62-6 ]
  • 4-(4-(((2-methoxyethyl)(methyl)amino)methyl)quinolin-2-yl)aniline [ No CAS ]
  • 52
  • [ 94205-62-6 ]
  • N-(4-(4-(morpholine-4-carbonyl)quinolin-2-yl)phenyl)acetamide [ No CAS ]
  • 53
  • [ 94205-62-6 ]
  • 2-hydroxy-N-(4-(4-(morpholinomethyl)quinolin-2-yl)phenyl)acetamide [ No CAS ]
  • 54
  • [ 94205-62-6 ]
  • methyl (E)-3-(2-(4-acetamidophenyl)quinolin-4-yl)acrylate [ No CAS ]
  • 55
  • [ 94205-62-6 ]
  • methyl 3-(2-(4-acetamidophenyl)quinolin-4-yl)propanoate [ No CAS ]
  • 56
  • [ 94205-62-6 ]
  • 4-(4-(morpholinomethyl)quinolin-2-yl)benzenamine [ No CAS ]
  • 57
  • [ 94205-62-6 ]
  • N-(4-(4-(morpholinomethyl)quinolin-2-yl)phenyl)acetamide [ No CAS ]
  • 58
  • [ 94205-62-6 ]
  • 2-(4-acetamidophenyl)-N-methoxy-N-methylquinoline-4-carboxamide [ No CAS ]
  • 59
  • [ 94205-62-6 ]
  • N-(4-(4-acetylquinolin-2-yl)phenyl)acetamide [ No CAS ]
  • 60
  • [ 94205-62-6 ]
  • N-(4-(4-(1-morpholinoethyl)quinolin-2-yl)phenyl)acetamide [ No CAS ]
  • 61
  • [ 94205-62-6 ]
  • 2-(4-(2,2,2-trifluoroacetamido)phenyl)quinoline-4-carbonyl chloride [ No CAS ]
  • 62
  • [ 94205-62-6 ]
  • N-(4-(4-(2-diazoacetyl)quinolin-2-yl)phenyl)-2,2,2-trifluoroacetamide [ No CAS ]
  • 63
  • [ 94205-62-6 ]
  • 2,2,2-trifluoro-N-(4-(4-(2-morpholino-2-oxoethyl)quinolin-2-yl)phenyl)acetamide [ No CAS ]
  • 64
  • [ 94205-62-6 ]
  • [ 407-25-0 ]
  • 2-(4-(2,2,2-trifluoroacetamido)phenyl)quinoline-4-carboxylic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In dichloromethane; at 0 - 20℃; for 2h; StepA: 2-(4-(2,2,2-trifluoroacetamido)phenyl)quinoline-4-carboxylic acid (44) [00417] To a solution of <strong>[94205-62-6]2-(4-aminophenyl)quinoline-4-carboxylic acid</strong> (Compound 2, (1042) Example 1) (2.0 g, 7.57 mmol) in DCM (20 mL) was added 2,2,2-trifluoroacetic anhydride (2.38 g, 11.36 mmol) and Et3N(1.53 g, 15.14 mmol) at 0C. The mixture was stirred at room temperature for 2 h. The resulting solution was quenched with water (100 ml) and extracted with DCM (50 mL x 2). The combined organic layers were concentrated and the crude was without purification to give the product (2.5 g, 91%) as a light yellow solid. LC-MS: (M + H)+ 361.1
Same Skeleton Products
Historical Records