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[ CAS No. 952906-02-4 ] {[proInfo.proName]}

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Chemical Structure| 952906-02-4
Chemical Structure| 952906-02-4
Structure of 952906-02-4 * Storage: {[proInfo.prStorage]}
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Product Details of [ 952906-02-4 ]

CAS No. :952906-02-4 MDL No. :MFCD10692399
Formula : C9H11FN2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 166.20 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 952906-02-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 952906-02-4 ]

[ 952906-02-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 887351-37-3 ]
  • [ 952906-02-4 ]
YieldReaction ConditionsOperation in experiment
94% With hydrogen In ethanol at 20℃; 1.2 Intermediate 9-b (16 g, 82 mmol) in ethanol (200 mL) was hydrogenated at room temperature with wet 10 % Pd/C as a catalyst overnight. After uptake of H2 (3 eq), the catalyst was filtered off and the filtrate was evaporated. The residue was washed with ethanol to afford the title compound 9-c (12.8 g, 94%) as a white solid, m/z = 167 (M+H)+.
94% With hydrogen In ethanol at 20℃; 1.12.2 Intermediate 12-b (16 g, 82 mmol) in ethanol (200 mL) was hydrogenated at room temperature with wet 10 % Pd/C as a catalyst overnight. After uptake of H2 (3 eq), the catalyst was filtered off and the filtrate was evaporated. The residue was washed with ethanol to afford the title compound 9-c as a white solid (12.8 g, 94%). m/z = 167 (M+H)+.
94% With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; 1.2 Step 2: Synthesis of N1-cyclopropyl-4-fluorobenzene-1,2-diamine 9-c Intermediate 9-b (16 g, 82 mmol) in ethanol (200 mL) was hydrogenated at room temperature with wet 10% Pd/C as a catalyst overnight. After uptake of H2 (3 eq), the catalyst was filtered off and the filtrate was evaporated. The residue was washed with ethanol to afford the title compound 9-c (12.8 g, 94%) as a white solid. m/z=167 (M+H)+.
With palladium 10% on activated carbon; hydrogen In ethanol for 16h; 9.2 A solution of 9a (50.0 g, 254.9 mmol) and 10% Pd/C (5.0 g, 4.7 mmol) in EtOH (1 .3 L) is stirred for 16 hours under a hydrogen atmosphere (50 psi). The reaction mixture is filtered through celite, concentrated and purified by flash chromatography to afford 9b.
With palladium on activated charcoal; hydrogen In methanol; ethyl acetate at 20℃;

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