Alternatived Products of [ 952906-02-4 ]
Product Details of [ 952906-02-4 ]
CAS No. : | 952906-02-4 |
MDL No. : | MFCD10692399 |
Formula : |
C9H11FN2
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
166.20
|
Pubchem ID : | - |
Synonyms : |
|
Safety of [ 952906-02-4 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 952906-02-4 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 952906-02-4 ]
- 1
-
[ 887351-37-3 ]
-
[ 952906-02-4 ]
Yield | Reaction Conditions | Operation in experiment |
94% |
With hydrogen In ethanol at 20℃; |
1.2
Intermediate 9-b (16 g, 82 mmol) in ethanol (200 mL) was hydrogenated at room temperature with wet 10 % Pd/C as a catalyst overnight. After uptake of H2 (3 eq), the catalyst was filtered off and the filtrate was evaporated. The residue was washed with ethanol to afford the title compound 9-c (12.8 g, 94%) as a white solid, m/z = 167 (M+H)+. |
94% |
With hydrogen In ethanol at 20℃; |
1.12.2
Intermediate 12-b (16 g, 82 mmol) in ethanol (200 mL) was hydrogenated at room temperature with wet 10 % Pd/C as a catalyst overnight. After uptake of H2 (3 eq), the catalyst was filtered off and the filtrate was evaporated. The residue was washed with ethanol to afford the title compound 9-c as a white solid (12.8 g, 94%). m/z = 167 (M+H)+. |
94% |
With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; |
1.2 Step 2: Synthesis of N1-cyclopropyl-4-fluorobenzene-1,2-diamine 9-c
Intermediate 9-b (16 g, 82 mmol) in ethanol (200 mL) was hydrogenated at room temperature with wet 10% Pd/C as a catalyst overnight. After uptake of H2 (3 eq), the catalyst was filtered off and the filtrate was evaporated. The residue was washed with ethanol to afford the title compound 9-c (12.8 g, 94%) as a white solid. m/z=167 (M+H)+. |
|
With palladium 10% on activated carbon; hydrogen In ethanol for 16h; |
9.2
A solution of 9a (50.0 g, 254.9 mmol) and 10% Pd/C (5.0 g, 4.7 mmol) in EtOH (1 .3 L) is stirred for 16 hours under a hydrogen atmosphere (50 psi). The reaction mixture is filtered through celite, concentrated and purified by flash chromatography to afford 9b. |
|
With palladium on activated charcoal; hydrogen In methanol; ethyl acetate at 20℃; |
|
Reference:
[1]Current Patent Assignee: JOHNSON & JOHNSON INC - WO2012/80447, 2012, A1
Location in patent: Page/Page column 20
[2]Current Patent Assignee: JOHNSON & JOHNSON INC - WO2012/80449, 2012, A1
Location in patent: Page/Page column 24
[3]Current Patent Assignee: JOHNSON & JOHNSON INC - US2013/267555, 2013, A1
Location in patent: Paragraph 0092; 0102-0103
[4]Current Patent Assignee: MEDIVIR AB - WO2015/65336, 2015, A1
Location in patent: Page/Page column 22; 23
[5]Ferreira, Rafael Augusto Alves; Junior, Celso de Oliveira Rezende; Martinez, Pablo David Grigol; Koovits, Paul John; Soares, Bruna Miranda; Ferreira, Leonardo L. G.; Michelan-Duarte, Simone; Chelucci, Rafael Consolin; Andricopulo, Adriano D.; Galuppo, Mariana K.; Uliana, Silvia R. B.; Matheeussen, An; Caljon, Guy; Maes, Louis; Campbell, Simon; Kratz, Jadel M.; Mowbray, Charles E.; Dias, Luiz Carlos
[PLoS Neglected Tropical Diseases, 2021, vol. 15, # 2]