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CAS No. : | 955365-79-4 | MDL No. : | |
Formula : | C23H29NO3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 367.48 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Class: | ||
Precautionary Statements: | UN#: | ||
Hazard Statements: | Packing Group: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
82% | A solution of lithium hexamethyl disilazide (LHMDS) in tetrahydrofuran (388.5ml, 0.46mol) was added to a well stirred solution of acetamide (III) (50g, 0.185mol) in dry tetrahydrofuran (1000ml) maintaining the temperature at -600C to -700C. The mixture was stirred for 15 minutes. Cyclohexanone (23ml, 0.223mol) was added maintaining the temperature at -600C to -700C. After completion of the reaction, a saturated aqueous solution of ammonium chloride was added. Dilute hydrochloric acid was added to adjust <n="14"/>the pH to 4.0 and the mixture was extracted with ethyl acetate (3 x 150ml). The combined organic extracts were washed with water and dried over anhydrous sodium sulphate. Concentration of the extracts afforded the desired amide (IV) as an off-white solid. The structure of the product was confirmed by 1H-NMR. Weight of the product = 56g; molar yield = 82%. |