Home Cart 0 Sign in  

[ CAS No. 956699-06-2 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 956699-06-2
Chemical Structure| 956699-06-2
Structure of 956699-06-2 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 956699-06-2 ]

Related Doc. of [ 956699-06-2 ]

Alternatived Products of [ 956699-06-2 ]

Product Details of [ 956699-06-2 ]

CAS No. :956699-06-2 MDL No. :MFCD22393655
Formula : C11H17N3O Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 207.28 Pubchem ID :-
Synonyms :

Safety of [ 956699-06-2 ]

Signal Word: Class:
Precautionary Statements: UN#:
Hazard Statements: Packing Group:

Application In Synthesis of [ 956699-06-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 956699-06-2 ]

[ 956699-06-2 ] Synthesis Path-Downstream   1~5

  • 1
  • (2S,6R)-2,6-dimethyl-4-(5-aminopyridin-2-yl)morpholine [ No CAS ]
  • 2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxyIic acid [ No CAS ]
  • [ 956697-53-3 ]
YieldReaction ConditionsOperation in experiment
93.6% In a 500 ml four-necked flask equipped with a stirring, thermometer, reflux condenser and exhaust gas absorption device,Add 250 g of 1,2-dichloroethane, 31.5 g (0.11 mol) of 2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxylic acid (VI) ,0.05 g of DMF, 17.9 g (0.15 mol) of thionyl chloride, stirred at 55-60 C for 4 hours.Excess chlorosulfoxide and solvent were recovered by distillation under reduced pressure, and the residue acid chloride was dissolved in 100 g of fresh 1,2-dichloroethane (acid chloride solution) and transferred to a constant pressure dropping funnel.In a 500 ml four-necked flask with stirring, thermometer, reflux condenser and exhaust gas absorption device,Add 200 grams of 1,2-dichloroethane,15.2 g (0.11 mol) potassium carbonate, 20.7 g (0.1 mol) of (2S,6R)-2,6-dimethyl-4-(5-aminopyridin-2-yl)morpholine (V) obtained by the method of Example 5. ),The solution of the acid chloride obtained above was added dropwise at 40-45 C for 2 hours, and then stirred at 45-50 C for 4 hours.The mixture was cooled to 20-25 C, filtered, and the filter cake was washed twice with 1,2-dichloroethane, 50 g each time, and the filtrate was combined. The filtrate was washed twice with saturated aqueous sodium chloride solution, 30 g each time. The organic phase is separated, and the organic phase is distilled under reduced pressure to recover the solvent.To the residue was added 0.5 g of activated carbon, 200 g of isopropanol, and decolorized at 80-82 C for 1 hour.
  • 2
  • (2S,6R)-2,6-dimethyl-4-(5-aminopyridin-2-yl)morpholine [ No CAS ]
  • [ 956697-53-3 ]
  • 3
  • [ 956699-06-2 ]
  • [ 1218778-77-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide 2: sodium carbonate; tetrakis(triphenylphosphine) palladium(0); water / toluene; ethanol / 135 °C 3: phosphoric acid / acetonitrile
  • 4
  • [ 956699-06-2 ]
  • [ 1812221-73-0 ]
  • [ 1812219-63-8 ]
YieldReaction ConditionsOperation in experiment
85% Stage #1: (2S,6R)-2,6-dimethyl-4-(5-aminopyridin-2-yl)morpholine With trimethylaluminum In dichloromethane; toluene at 0 - 20℃; for 0.25h; Stage #2: 5-bromo-isochroman-1-one In dichloromethane; toluene at 20℃; for 3h; 70.1 Step 1 Step 1: A solution of trimethyl aluminum (2 mol/L, 3.85 mL) in toluene was added into a solution of compound70-2 in dry DCM (20 mL) at 0 °C, the reaction mixture was stirred at room temperature for 15 min. Then a solution ofcompound 70-1 (0.7 g, 3.1 mmol) in DCM (5 mL) was added dropwise, and the obtained solution was stirred at roomtemperature for 3h. After the reaction was complete as detected by LCMS, Rochelle salt solution was added. Theobtained mixture was extracted with DCM, washed with brines, dried over anhydrous sodium sulfate, and concentratedEP 3 124 482 A158510152025303540455055under reduced pressure. The residue was purified by silica gel column chromatography (PE/EtOAc= 5:1) to delivercompound 70-3 (1.1 g, 85%) as yellow solid. MS ESI calcd for C20H24BrN3O3 [M+H]+ 435, found 435.
  • 5
  • [ 956699-06-2 ]
  • [ CAS Unavailable ]
  • [ 956697-53-3 ]
YieldReaction ConditionsOperation in experiment
In neat (no solvent) at 60℃;
Same Skeleton Products
Historical Records