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[ CAS No. 99065-34-6 ] {[proInfo.proName]}

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Chemical Structure| 99065-34-6
Chemical Structure| 99065-34-6
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COA NMR CNMR HPLC LC-MS

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Product Details of [ 99065-34-6 ]

CAS No. :99065-34-6 MDL No. :MFCD08234752
Formula : C9H17NO2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 171.24 Pubchem ID :-
Synonyms :

Safety of [ 99065-34-6 ]

Signal Word: Class:
Precautionary Statements: UN#:
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Application In Synthesis of [ 99065-34-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 99065-34-6 ]

[ 99065-34-6 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 28247-14-5 ]
  • [ 99065-34-6 ]
YieldReaction ConditionsOperation in experiment
With hydrogen In ethanol
With hydrogen
With ammonia In aluminum nickel; ethanol 39.a N-(2-Ethoxycarbonyl-2,2-tetramethylen-ethyl)-N-pentanoyl-N-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-amine a) Ethyl 1-aminomethyl-cyclopentane-1-carboxylate is obtained by hydrogenating 33 g of ethyl 1-cyanocyclopentane-1-carboxylate (Alfred Bader Chemicals) in the presence of 10 g of Raney nickel, at 45° C. and under normal pressure in 330 ml of ethanol which contains about 4% ammonia. After filtering off the catalyst and removing the solvent in vacuo, the product is obtained by distillation, b.p. 71°-74° C. at 0.75 mbar.
With ammonia In aluminum nickel; ethanol 2.a EXAMPLE 2 a) 1-Aminomethylcyclopentane-1-carboxylic acid ethyl ester is obtained by hydrogenating 33 g of 1-cyanocyclopentane-1-carboxylic acid ethyl ester (Alfred Bader Chemicals) in 330 ml of ethanol, which contains approximately 4% ammonia, in the presence of 10 g of Raney nickel at 45° and under normal pressure. After filtering off from the catalyst and removing the solvent in vacuo, the product is obtained by distillation, b.p. 71°-74° at 0.75 mbar.

Reference： [1]Testa,E. et al. [Justus Liebigs Annalen der Chemie, 1961, vol. 639, p. 166 - 180]
[2]Fotouhi, Nader; Joshi, Pramod; Fry, David; Cook, Charles; Tilley, Jefferson W.; Kaplan, Gerry; Hanglow, Angela; Rowan, Karen; Schwinge, Virginia; Wolitzky, Barry [Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 11, p. 1171 - 1173]
[3]Current Patent Assignee: Novartis (w/o Sandoz); NOVARTIS AG - US5399578, 1995, A
[4]Current Patent Assignee: Novartis (w/o Sandoz); NOVARTIS AG - US5506240, 1996, A
  • 2
  • [ 99065-34-6 ]
  • [ 204514-22-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 2: NaOH / dioxane
Reference： [1]Fotouhi, Nader; Joshi, Pramod; Fry, David; Cook, Charles; Tilley, Jefferson W.; Kaplan, Gerry; Hanglow, Angela; Rowan, Karen; Schwinge, Virginia; Wolitzky, Barry [Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 11, p. 1171 - 1173]
  • 3
  • CH2 Cl2 -MeOH [ No CAS ]
  • [ 99065-34-6 ]
  • [ 135689-93-9 ]
  • [ 137864-26-7 ]
YieldReaction ConditionsOperation in experiment
39.b N-(2-Ethoxycarbonyl-2,2-tetramethylen-ethyl)-N-pentanoyl-N-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-amine b) Ethyl N-[(2'-cyanobiphenyl-4-yl)methyl]-1-aminomethylcyclopentane-1-carboxylate is obtained from 4.15 g of 2'-cyanobiphenyl-4-carbaldehyde and 4.15 g of ethyl 1-aminomethylcyclopentane-1-carboxylate analogously to Example 1b) and purified on silica gel 60 (40-63 μm) using CH2 Cl2 -MeOH 99.5:0.5, Rf =0.38 (system N6).
Reference： [1]Current Patent Assignee: Novartis (w/o Sandoz); NOVARTIS AG - US5399578, 1995, A
  • 4
  • [ 28247-14-5 ]
  • [ 96042-30-7 ]
  • [ 99065-34-6 ]
YieldReaction ConditionsOperation in experiment
With ammonium hydroxide; ammonia In methanol; ethanol 29.B B B Ethyl 1-aminomethylcyclopentanecarboxylate This compound is prepared by the catalytic hydrogenation of ethyl 1-cyanocyclopentanecarboxylate. 20 g of ethyl 1-cyanocyclopentanecarboxylate are placed in 200 ml of a 10% solution of ammonia in ethanol and hydrogenated at 60° C. under a pressure of 100 bar in the presence of rhodium-on-alumina for 72 hours. After filtration on cellite and evaporation, the residue is chromatographed on silica using a DCM/methanol/20% aqueous ammonia mixture (98/2/0.5; v/v/v) as the eluent. m=12.8 g.
Reference： [1]Current Patent Assignee: SANOFI - US5270317, 1993, A

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