Proprotein convertases (PCs) are a class of serine proteases responsible for cleaving and activating various proproteins and propeptides, including hormones, growth factors, and receptors. The PC family mainly includes members such as PC1/3, PC2, Furin, PC4, PC5/6, PACE4, PC7, and SKI-1/S1P. These enzymes are located in the Golgi apparatus and endoplasmic reticulum and are widely distributed in various tissues and cell types. PCs are involved in regulating various physiological processes, such as endocrine secretion, cell proliferation, immune response, and viral infection. The specific expression and mutations of the genes are associated with various diseases, including metabolic disorders, tumors, neurodegenerative diseases, and infectious diseases.