PTHR (Parathyroid Hormone Receptor) belongs to the G protein-coupled receptor family, mainly consisting of seven transmembrane domains. It is predominantly expressed on the surface of bone and kidney cells, regulating the metabolism of calcium and phosphorus. This receptor participates in maintaining blood calcium levels by activating the cAMP signaling pathway. Specific expression of PTHR is crucial for bone health and mineral balance, with mutations potentially leading to osteoporosis and related metabolic abnormalities.