Products Cited in Publications Worldwide 2-Chloro-4-hydroxyanilinium chloride

2-Chloro-4-hydroxyanilinium chloride

Bai, Sindhu V; Mensah, Patrick F; Li, Guoqiang; Fronczek, Frank R; Uppu, Rao M

DOI:

Abstract

The title compound, C6H7ClNO+·Cl−, crystallizes in ortho­rhom­bic space group Pnma with both cations and anions lying on a mirror plane in the crystal. The C—Cl distance is 1.7289 (6) Å, the C—N distance is 1.4590 (8) Å, and the C—O distance is 1.3617 (8) Å. Parallel mol­ecules form stacks with inter­planar spacing 3.1473 (2) Å, but slipped by 1.97 Å. The NH3+ substituent donates three inter­molecular hydrogen bonds to chloride ions having N⋯Cl distances in the range 3.1514 (6)–3.3019 (2) Å, and the OH group donates an inter­molecular hydrogen bond to chloride with O⋯Cl distance 3.0671 (6) Å. The chloro substituent and OH group do not accept hydrogen bonds from NH or OH.

Keywords

crystal structure ; 4-amino-3-chloro­aniline ; lenvatinib and tivozanib ; tyrosine kinase inhibitors ; anti­cancer drugs and inter­mediates

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A11730152671-64-498%

4-Amino-3-chlorophenol hydrochloride

18.0/10g

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