Chemistry Heterocyclic Building Blocks Pyridines picolinaldehyde
Aldol condensation: Picolinaldehyde can undergo aldol condensation reactions with itself or with other carbonyl compounds in the presence of a base, leading to the formation of β-hydroxy aldehydes or β-hydroxy ketones.
Grignard reaction: Picolinaldehyde can react with Grignard reagents (organomagnesium compounds) to form alcohols after hydrolysis.
Cannizzaro reaction: Under certain conditions, picolinaldehyde can undergo Cannizzaro reaction, particularly in concentrated alkaline solutions, forming the corresponding alcohol and carboxylic acid.
Oxidation reactions: Picolinaldehyde can be oxidized to form picolinic acid, which is a common oxidation product of pyridine-containing compounds. Various oxidizing agents such as chromic acid, potassium permanganate, or Jones reagent can be used for this purpose.
Reduction reactions: Picolinaldehyde can be reduced to picolinalcohol using reducing agents such as sodium borohydride (NaBH4) or lithium aluminum hydride (LiAlH4).
Mannich reaction: Picolinaldehyde can undergo Mannich reaction with a primary or secondary amine and formaldehyde to yield β-amino alcohols.
Acetal formation: Picolinaldehyde can react with alcohols in the presence of an acid catalyst to form acetals or hemiacetals.
Michael addition: Picolinaldehyde can undergo Michael addition reactions with nucleophiles such as thiols, amines, or active methylene compounds.
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3-Fluoro-5-(trifluoromethyl)picolinaldehyde
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3-Methyl-5-(trifluoromethyl)picolinaldehyde
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3-Hydroxy-5-(trifluoromethyl)picolinaldehyde
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5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinaldehyde
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5-Bromo-6-methyl-3-pyridinecarboxaldehyde
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3-Chloro-5-(trifluoromethyl)picolinaldehyde
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6-(Trifluoromethyl)-2-pyridinecarboxaldehyde
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4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinaldehyde
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3-Bromo-5-(trifluoromethyl)picolinaldehyde
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3-Bromo-6-(trifluoromethyl)picolinaldehyde
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5-Bromo-3-(trifluoromethyl)picolinaldehyde