Chemistry Heterocyclic Building Blocks Pyrroles
A colorless and volatile liquid, pyrrole darkens quickly when exposed to air. It is an organic compound that is both heterocyclic and aromatic, featuring a five-membered ring with the chemical formula C4H4NH.
Pyrroles are building blocks of intricate macrocycles that comprise porphyrinogens and their derived products, such as heme's porphyrins, chlorins, bacteriochlorins, and chlorophylls.
Pyrrole, similar to furan and thiophene, is an aromatic heterocycle composed of five members. However, unlike furan and thiophene, it possesses a dipole moment of 1.58 D, with the positive end situated on the heteroatom's side.
Pyrrole and its derivatives find extensive application as intermediates in the production of various organic compounds, such as pharmaceuticals, medicines, agrochemicals, dyes, photographic chemicals, perfumes, and more.
The pharmacological significance of pyrroles stems from their involvement in the anti-inflammatory, analgesic, antimicrobial, antitumor, antiepileptic, antiviral, antidiabetic, and antihypertensive activities of different pharmaceuticals.
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Octahydro-1H-pyrrolo[3,4-c]pyridine dihydrochloride
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(3aR,6aR)-Hexahydrocyclopenta[c]pyrrole-3a(1H)-carboxylic acid
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Methyl (3aS,6aR)-5-benzyltetrahydro-1H-thieno[3,4-c]pyrrole-3a(3H)-carboxylate 2,2-dioxide
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N-(5-Iodo-4-oxo-7-tosyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide
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5-Amino-1-(tert-butyl)-1H-pyrrole-3-carbonitrile
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1-(4-Fluorophenyl)-1h-pyrrole-2-carboxylic acid
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Methyl 4,5-Dibromo-1-methylpyrrole-2-carboxylate
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Ethyl 5-(trifluoromethyl)-1H-pyrrole-2-carboxylate
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Ethyl 5-bromo-2-methyl-1H-pyrrole-3-carboxylate
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tert-Butyl (2-cyano-1H-pyrrol-1-yl)carbamate
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Methyl 4-phenyl-1H-pyrrole-3-carboxylate
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Ethyl 4-(trifluoromethyl)-1H-pyrrole-3-carboxylate